The AMEX Biotechnology Index lost 0.30 points Wednesday to159.12. Centocor shares (NASDAQ:CNTO) added $3 to Tuesday's$1 gain, while units of its Tocor II R&D spinoff (NASDAQ:TOCRZ)gained $1.50 to $26.50. Genetics Institute Inc. (NASDAQ:GENIZ)fell $1.50 to $26.50 after reporting an anticipated $30 millioncharge related to its merger with American Home ProductsCorp. GI said it lost $1.73 per share in its first quarter endedFeb. 29, compared with a $1.20 loss in 1991. Other stocks weremixed.

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