Research in rhesus monkeys has shown a gene therapy that enhanced activity in dopamine producing neurons in the brain was effective at stopping excessive alcohol consumption in previously addicted animals.
When tissue injury occurs, stressed cells release a bunch of intracellular molecules called damage-associated molecular pattern (DAMP) proteins. S100 calcium binding protein A9 (S100A9) is a DAMP usually found in macrophages and is involved in multiple inflammatory responses, such as activation of Toll-like receptor 4 (TLR4).
The shunt towards, or away from, cognitive decline may happen decades before such decline becomes clinically evident. And known risk factors explain very little of that decline. That is the conclusion reached by researchers from the Ohio State University, who published their results in the Feb. 8, 2023, issue of PLOS ONE.
In their analysis, the team looked at both the absolute level of cognitive function in about 7,000 participants of the U.S. Health and Retirement Study at age 54, and at the decline in cognitive function from age 54 to 85. The study participants that were analyzed were born between 1931 and 1941. The results were reminiscent of the adage that the way to make a silk purse out a sow’s ear is to start with a silk sow.
Acute myeloid leukemia (AML) is characterized by hematopoietic precursors arrested in early stages of development. Approximately 20,000 diagnoses and 11,000 deaths occur annually in the United States despite treatment advances.
A group of scientists from The Ohio State University (OSU) in collaboration with the University of Chicago has found that targeting the enzyme NSUN2 could be used against a wide range of viruses. Its deficiency could stop infection by inhibiting gene expression and viral replication.
Song Guo Zheng, a rheumatology professor and researcher at Ohio State University (OSU), was sentenced May 14 to 37 months in prison for lying on U.S. NIH grant applications about his ties to at least five Chinese research institutes.
.webp?height=488&t=1670008838&width=650 "Acute myeloid leukemia")
