Astrazeneca has described spirocyclic compounds acting as protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.
F. Hoffmann-La Roche Ltd. and Hoffmann-La Roche Inc. have identified macrocyclic compounds acting as GTPase KRAS (G12C) mutant inhibitors reported to be useful for the treatment of cancer.
CD73 is known to induce immune evasion in solid tumors by release of immune-suppressive adenosine in the tumor microenvironment. Researchers from Cidara Therapeutics Inc. have presented preclinical data on the CD73 inhibitor drug FC-conjugate CBO-212 for the potential treatment of solid tumors.
Medshine Discovery Inc. has divulged nuclear receptor ROR-γ (RORC) agonists or RORC inverse agonists reported to be useful for the treatment of cancer.
Shanghai Litedd Co. Ltd. has divulged 8-oxo-3-azabicyclo[3.2.1]octane compounds acting as ATR kinase inhibitors reported to be useful for the treatment of cancer.
Adlai Nortye Pharmaceutical Co. Ltd. has identified Wnt signaling inhibitors reported to be useful for the treatment of cancer, immunological and inflammatory disorders.
