Investigators at West China Hospital, Sichuan University and affiliated organizations have discovered a novel c-Myc inhibitor being developed as a potential anticancer agent.

Male infertility affects approximately 20% to 70% of infertile couples mostly due to decreased sperm count, sperm motility and/or morphological abnormalities.

Topoisomerase I (topo I) and cyclooxygenase-2 (COX-2) are known targets in colon cancer, and Chinese scientists have sought dual topo I/COX-2 inhibitors to provide anticancer activity without the potential for side effects seen with combined therapy.