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Home » Topics » Clinical, BioWorld Asia

Clinical, BioWorld Asia
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Hengrui/Kailera obesity asset delivers solid weight loss in phase III

July 22, 2025
By Karen Carey
No Comments
A glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor dual agonist developed by Jiangsu Hengrui Pharmaceuticals Co. Ltd. and licensed by Kailera Therapeutics Inc. has shown a mean weight loss of 19.2% at the 6-mg dose with no plateau over 48 weeks in a phase III trial conducted in China.
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Coin inserted into Australian map

Australia awards AU$100M in grants to biopharma/med-tech incubators

July 22, 2025
By Tamra Sami
No Comments
The Australian government has awarded nearly AU$100 million (US$64.65 million) in grant funding to three biopharma/med-tech incubators to support emerging Australian biopharma and med-tech startups.
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Single strand RNA
Newco news

In ongoing mRNA evolution, SML Biopharm sights new cancer vaccines

July 22, 2025
By Marian (YoonJee) Chu
No Comments
SML Biopharm Co. Ltd. is harnessing mRNA technology to develop novel immunotherapy-based cancer vaccines, including two candidates for cervical and head and neck cancers caused by human papillomavirus (HPV) infection.
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Skin irritation on hands

Livzon’s IL-17A/F meets phase III endpoints in plaque psoriasis ​

July 22, 2025
By Tamra Sami
No Comments
Livzon Mabpharm Inc.’s anti-IL-17A/F monoclonal antibody, LZM-012, met the primary endpoint in a phase III trial in moderate to severe plaque psoriasis. Conducted at Fudan University’s Huashan Hospital, the phase III multicenter, randomized, double-blind, active-controlled (secukinumab) trial enrolled 926 patients with moderate to severe plaque psoriasis.
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More Chinese ADCs enter the clinic as biotech race heats up

July 15, 2025
By Tamra Sami
No Comments
China has proved to be a fertile ground for innovation as evidenced by some big deals in the antibody-drug conjugate (ADC) space, and the number of candidates entering clinical trials in China or being advanced in the U.S. by Chinese companies.
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Brain with clock hands, day and night background

Takeda phase IIIs win; Street still wants a visual on narcolepsy

July 15, 2025
By Randy Osborne
No Comments
Takeda Pharmaceutical Co. Ltd.’s dual phase III victories in narcolepsy type 1 (NT1) with oral orexin receptor 2 (OX2R)-selective agonist oveporexton (also known as TAK-861) had Wall Street mulling what the outcome might mean for others trying the mechanism of action, and questions linger about side effects on eyesight.
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3D rendering of CAR T therapy in cell

Imugene’s allogeneic CD19 CAR T sees 75% response rate

July 15, 2025
By Tamra Sami
No Comments
Immuno-oncology company Imugene Ltd.’s allogeneic, off-the-shelf CD19 CAR T, azercabtagene zapreleucel (azer-cel), has resulted in seven complete responses and three partial responses in a phase Ib trial in relapsed diffuse large B-cell lymphoma patients, according to an interim analysis. The responses to date show a 75% overall response rate.
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Digital lungs illustration

Bioversys, Shionogi in CHF529M lung infection collaboration

July 8, 2025
By Nuala Moran
No Comments
Antibiotics specialist Bioversys AG has sealed a potential CHF529 million (US$667.5 million) deal with Shionogi Co. Ltd., in which they will work together on novel ansamycins for treating multidrug-resistant lung infections caused by non-tuberculous mycobacteria.
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Man using walker with assistance

Taiho’s pizuglanstat fails in phase III DMD trial

July 8, 2025
By Tamra Sami
No Comments
In yet another fail for the Duchenne muscular dystrophy (DMD) field, Taiho Pharmaceutical Co. Ltd.’s pizuglanstat (TAS-205) did not meet the primary endpoint in a phase III trial. The phase III Reach-DMD trial, a randomized, placebo-controlled, double-blind and open-label, extension study of pizuglanstat in patients with DMD showed no significant difference in the mean change from baseline to 52 weeks in the primary endpoint of time to rise from the floor in the ambulatory cohort of the study.
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Xia Jin, CEO and co-founder of Immuno Cure, and Dan Mallon, senior vice president of corporate development for Pharmajet

Immuno Cure, Pharmjet partner on needle-free HIV vaccine trial

June 24, 2025
By Tamra Sami
No Comments
Immuno Cure Biotech Ltd. is collaborating with Pharmajet Inc. to evaluate the safety and immunogenicity of its HIV therapeutic DNA vaccine, Icvax, delivered via Pharmajet's innovative Tropis needle-free injection system.
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