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BioWorld - Sunday, December 10, 2023
Home » Topics » Clinical

Clinical
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Paxmedica rebounds on published autism results for PAX-101

Nov. 7, 2023
By Karen Carey
No Comments
Paxmedica Inc.’s shares (NASDAQ:PXMD) surged by 179% in early trading Nov. 7 after reporting the publication of phase II autism spectrum disorder results for PAX-101 (suramin) intravenous infusions. Suramin, an anti-trypanosomal and anti-purinergic agent introduced in 1923 for East African sleeping sickness, showed a statistically significant improvement at the 10-mg/kg dose in a secondary endpoint of Clinical Global Impressions – Improvement scale vs. placebo.
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Woman itching wrist

Psoriasis, arthritis scratched but CD still plays in Ventyx TYK2 bid

Nov. 7, 2023
By Randy Osborne
No Comments
Having rolled out less-than-stellar phase II data with oral TYK2 inhibitor VTX-958 in moderate to severe plaque psoriasis, Ventyx Biosciences Inc. faces Wall Street speculation regarding the odds for the ongoing effort in Crohn’s disease (CD), due for an interim analysis in the first quarter of next year.
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Moonlake stock drops as phase II data in psoriatic arthritis is posted

Nov. 6, 2023
By Lee Landenberger
No Comments
Top-line results from Moonlake Immunotherapeutics AG’s phase II study of sonelokimab treating active psoriatic arthritis encouraged the company but discouraged investors.
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Kymera’s early stage data show progress in lymphoma

Nov. 3, 2023
By Lee Landenberger
No Comments
Kymera Therapeutics Inc.’s KT-333 new phase I data, while early in the STAT3 targeted protein degrader’s development, showed results that cheered the company’s stock. It didn’t hurt that the company also took in a $40 million milestone from partner Sanofi SA in their collaboration to develop the IRAK4 degrader KT-474.
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Macrophage releasing cytokines as a part of the body's immune response.

Indukine potential unmasked with early Werewolf data

Nov. 3, 2023
By Randy Osborne
No Comments
Shares of Werewolf Therapeutics Inc. (NASDAQ:HOWL) reflected enthusiasm on Wall Street for the prospect, albeit early stage, of systemically delivering a masked native interleukin-2 (IL-2) cytokine to cancer patients.
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ASH preview: Among the flood of abstracts, Arcellx’s phase I data move its stock

Nov. 2, 2023
By Lee Landenberger
No Comments
Among the avalanche of abstracts for the upcoming American Society of Hematology (ASH) annual conference released early on Nov. 2 were data from Arcellx Inc.’s phase I study of CART-ddBCMA in patients with relapsed or refractory multiple myeloma. The results caught investors’ attention as the company’s stock (NASDAQ:ACLX) jumped 18.5% upward to close at $40.77 per share.
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Esophageal cancer

Oncolys esophageal cancer drug Telomelysin hits phase II endpoints

Oct. 31, 2023
By Tamra Sami
No Comments
Oncolys Biopharma Inc.’s lead compound Telomelysin (suratadenoturev, OBP-301) met the primary endpoint of exceeding the predefined threshold of local complete response, confirming clinical benefit in a phase II study in locally advanced esophageal cancer combined with radiation.
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Vim’s vigor in TGCT verified in phase III as Deciphera ‘pex’ at Daiichi’s heels

Oct. 31, 2023
By Randy Osborne
No Comments
With Deciphera Pharmaceuticals Inc.’s positive top-line data in hand from the pivotal phase III study called Motion, Wall Street speculation turned to the comparative safety and regulatory odds for vimseltinib (which analysts often refer to as “vim”) in patients with tenosynovial giant cell tumor (TGCT) not amenable to surgery.
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Test tubes, capsules, dropper
Biopharma clinical updates September 2023

Clinical trial data show 1.79% growth year-on-year through Q3 2023

Oct. 31, 2023
By Amanda Lanier
No Comments
Clinical trial data from January-September 2023 was up 1.79% compared to the same time period last year. In the first three quarters of this year, BioWorld reported on 2,611 drugs in phase I-III, compared to 2,565 in Q1-Q3 2022. The number of trial updates is down 13.74% from 3,027 in 2021 and also down from the 2,738 in 2020, but up from 2,251 updates noted in 2019.
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Lianbio says hit-and-miss for co-primary endpoints in Xdemvy’s China trial

Oct. 31, 2023
By Marian (YoonJee) Chu
No Comments
Lianbio Co. Ltd. announced mixed phase III top-line results on Oct. 30 for its in-licensed Demodex blepharitis treatment called TP-03, with the U.S. FDA-approved eyedrop hitting just one co-primary endpoint in the Libra trial on Chinese patients.
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