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Home » Topics » Conferences » American Association for Cancer Research

American Association for Cancer Research
American Association for Cancer Research RSS Feed RSS

Cancer

SY-13380: A novel menin/KMT2A inhibitor for aggressive leukemia

May 16, 2025
No Comments
Acute myeloid leukemia (AML) harboring KMT2A rearrangements (KMT2A-r) represents a highly aggressive disease subtype, characterized by poor therapeutic response and a high risk of relapse.
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Microscope with laptop displaying histology image.
Cancer

Preclinical studies support XNW-29016’s potential for treating HRD cancers

May 16, 2025
No Comments
DNA damage repair enzymes are interesting targets in cancer, since genomic instability and DNA repair defects are important cancer cell hallmarks. Poly (ADP-ribose) glycohydrolase (PARG) is the dominant eliminator of PARylation in the cell, the activity of which prevents excessive accumulation of PARylation, and promotes the dissociation of repair proteins, as well as ensuring the smooth completion of DNA repair process.
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Cancer

DAT-5000A has potency against tumors with microsatellite instability

May 16, 2025
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Werner syndrome ATP-dependent helicase (WRN) is an enzyme involved in DNA replication and repair and has been identified as a synthetic lethality target in tumors with high microsatellite instability (MSI-H).
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Antibodies attacking cancer cell
Immuno-oncology

New anti-CCR8 immuno-oncology antibodies with unique binding/pharmacology

May 15, 2025
No Comments
CCR8 is highly expressed on immunosuppressive regulatory T cells (Tregs) in various solid tumors, making it a potential target to enhance antitumor immunity and the efficacy of cancer therapies, including checkpoint inhibitors. However, the impact of CCR8 expression on the Treg phenotype and its role in cancer progression remain unclear.
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Cancer

QX-001280 exerts synergistic antitumoral activity when combined with olaparib

May 15, 2025
No Comments
Quantx Biosciences Ltd. has presented data on their novel DNA polymerase θ (POLQ) inhibitor QX-001280 for treating cancer.
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3D illustration of cancer in crosshairs
Immuno-oncology

Integrating antibody therapy and oncolytic virotherapy enhances effects

May 14, 2025
No Comments
Current anticancer approaches, such as antibody or CAR T-cell therapies, rely on targeting tumor-associated antigens rather than tumor-specific antigens, with the consequent on-target, off-tumor effects.
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Biomarkers

GPR171 is a prognostic marker in cervical cancer

May 14, 2025
No Comments
Recent evidence has shown that G protein-coupled receptor 171 (GPR171) may be a key T-cell checkpoint in tumor immunity.
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Cancer

Chinese researchers unveil new agent for KRAS G12D-mutated tumors

May 13, 2025
No Comments
The KRAS G12D mutation is the most common oncogenic KRAS variant, identified in approximately 34% of pancreatic ductal adenocarcinoma cases, 12% of colorectal cancers and 4% of lung adenocarcinomas.
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Cancer

New 5T4-targeted radiopharmaceutical shows single-dose efficacy in preclinical cancer models

May 13, 2025
No Comments
Radiopharmaceuticals can offer a targeted approach for cancers that have limited therapeutical options. Abdera Therapeutics Inc. recently presented results of their novel 5T4-targeted radiopharmaceutical.
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Immuno-oncology

BB-1705 optimizes profile of EGFR-targeting therapies

May 13, 2025
No Comments
Epidermal growth factor receptor (EGFR), when overactive or overexpressed, may lead to tumor growth and spread, and is thus a robust target for therapy.
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