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Home » Topics » Conferences » American Association for Cancer Research

American Association for Cancer Research
American Association for Cancer Research RSS Feed RSS

Cancer cells being destroyed by immunotherapy
Immuno-oncology

EGL-001, a new immunocytokine with unique mechanism, demonstrates potent antitumor efficacy

May 3, 2024
Researchers from Egle Therapeutics SAS presented the discovery of a novel immunocytokine, EGL-001, designed to selectively target tumor-infiltrating regulatory T cells (Tregs).
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Cancer

Pan-TEAD palmitoylation inhibitor suppresses tumor growth in Hippo pathway-altered cancer models

May 3, 2024
The TEAD family of transcription factors are regulated by the Hippo tumor suppressor pathway and they act by binding the co-activators YAP and TAZ that drive the transcription of genes involved in cell survival, proliferation, migration, differentiation and resistance.
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Cancer cells under magnifying glass
Cancer

CKD Pharm’s c-Met-targeting CKD-703 induces cancer cell death in solid tumors

April 30, 2024
Chong Kun Dang Pharm (CKD Pharm) has presented data on their c-Met-targeting antibody-drug conjugate (ADC) CKD-703 for the treatment of solid tumors. CKD-703 was designed based on site-specific conjugation, with a stable and homogeneous drug-antibody ratio profile.
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Antibody-drug conjugate illustration
Immuno-oncology

AT-2604, an anti-ALPP/ALPPL2 ADC with efficacy and improved safety

April 30, 2024
Researchers from Axcynsis Therapeutics Pte. Ltd. presented the development and preclinical characterization of AT-2604, a novel antibody-drug conjugate (ADC) targeting the placental alkaline phosphatases, ALPP and ALPPL2.
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3D illustration of cancer in crosshairs
Cancer

PARP-1 inhibitor HH-102007 shows synergy with carboplatin for cancer treatment

April 26, 2024
Poly(ADP-ribose) polymerase 1 (PARP-1) plays a crucial role in DNA repair and represents the pivotal target for first-generation PARP inhibitors.
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Components of a radiopharmaceutical
Cancer

Peptidream advances toward clinical studies of new radiopharmaceutical

April 26, 2024
Peptidream Inc. has reported that an early-phase clinical trial for 64Cu-PD-32766, a 64Cu-labeled radiopharmaceutical targeting carbonic anhydrase IX (CAIX), for patients with clear cell renal cell carcinoma has been approved by the clinical review board of the National Cancer Center Hospital East in Japan.
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Microscope with laptop displaying histology image.
Cancer

HSK-42360, a BRAF paradox breaker with efficacy in models of brain metastasis and BRAF-inhibitor resistance

April 26, 2024
Researchers from Haisco Pharmaceutical Group Co. Ltd. presented the discovery and preclinical characterization of a brain-penetrating BRAF paradox breaker, HSK-42360, being developed for the treatment of BRAF-driven cancers. HSK-42360 proved to be a potent BRAF V600E inhibitor (IC50=5 nM) with selectivity over wild-type BRAF.
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Lung cancer driven by the Kras oncogene shown in purple

Broader KRAS inhibition methods include chaperoning, gluing, vaccinating

April 24, 2024
By Anette Breindl
The existence of two approved therapies, Lumakras (sotorasib, Amgen Inc.) and Karzati (adagrasib, Mirati Therapeutics Inc.), has been a triumphant success against KRAS, a protein that was once considered undruggable.
Read More
CAR T cells attacking cancer cell
Immuno-oncology

Preclinical candidate KLN-1010 may address unmet needs in multiple myeloma

April 24, 2024
Multiple myeloma (MM) is still an uncurable disease. Chimeric antigen receptor (CAR) T cells directed to tumor necrosis factor receptor superfamily member 17, also known as BCMA, have transformed the field, with high response rate and durable remissions, but the access to this therapy is limited by multiple factors.
Read More
Cancer

Potent and highly selective CDK7 inhibitor, KRLS-017, shows antitumor efficacy in multiple xenograft models

April 24, 2024
Researchers from Kirilys Therapeutics Inc. presented findings from the preclinical evaluation of KRLS-017, a novel reversible cyclin-dependent kinase 7 (CDK7) inhibitor being developed for the treatment of advanced solid tumors.
Read More
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