Claudin-6 (CLDN6) is highly expressed in several cancer types, including ovarian and endometrial cancers, while very low or no expression is found in normal tissues.
Researchers from Compass Therapeutics Inc. reported on the preclinical characterization of CTX-8371, a bispecific tetravalent antibody that presented synergistic anti-PD-1/PD-L1 activity.
Kling Biotherapeutics BV has presented preclinical data on an antibody, KBA-1413, which recognizes a specific glycoform of CD43 that is shared among acute myeloid leukemia (AML), myelodysplastic syndrome (MDS) and solid tumor cells.
Zeno Management Inc. has identified antibody-drug conjugates comprising antibodies targeting inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) covalently bound to exatecan derivatives through a linker.
Researchers from Astrazeneca plc and affiliated organizations have described the discovery and preclinical evaluation of casitas B-lymphoma proto-oncogene-b (Cbl-b) inhibitors as novel anticancer candidates.
Abbvie Inc. and Tentarix Biotherapeutics Inc. have established a multiyear collaboration focused on the discovery and development of conditionally active, multispecific biologic candidates against one target in oncology and another in immunology.
South China University of Technology and affiliated organizations have published data from a study that aimed to assess the role of the recently identified human hexokinase, hexokinase domain component 1 (HKDC1), in regulating tumor immune cell response in hepatocellular carcinoma (HCC).
Researchers from Chonnam National University presented novel a doxycycline (Doxy)-inducible gene switch system in attenuated Salmonella typhimurium, one of the bacterial strains that has been previously shown to selectively colonize and multiply in tumors, leading to oxygen deprivation, excessive nutrient leakage, and an antitumor immune response.
Researchers from University of California Los Angeles and affiliated organizations published data from a study that aimed to identify novel surface proteins that are highly and selectively expressed in tumors and could serve as targets for chimeric antigen receptor (CAR) T-cell therapies for the treatment of melanoma.
The aryl hydrocarbon receptor (AhR) is a transcription factor that modulates the activity of tumor and immune cells, hence targeting AhR may represent a feasible option for cancer immunotherapy. Researchers from the Institute of Materia Medica of Beijing and collaborators recently reported on the discovery and synthesis of a novel series of AhR antagonists derived from Salvia miltiorrhiza Bunge intended to be used in cancer immunotherapy.
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.webp?height=488&t=1708619318&width=650 "Co-culture that shows the CAR T-cell clusters attacking the tumor cells (in green)")
