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Home » Topics » Drugs » Immuno-oncology

Immuno-oncology
Immuno-oncology RSS Feed RSS

Imunon ovarian cancer prospect impresses with survival benefits

May 23, 2025
By Karen Carey
No Comments
Imunon Inc. soared by 179% on the heels of phase II Ovation 2 data showing that its IMNN-001 immunotherapy led to a 13-month increase in overall survival among women with ovarian cancer. Patients in the intent-to-treat population, receiving the drug plus standard-of-care neoadjuvant and adjuvant chemotherapy (N/ACT), achieved median overall survival (OS) at 46 months vs. 33 months with N/ACT alone. Increased activity was seen among patients treated with poly ADP-ribose polymerase inhibitors, with the median OS not yet reached after more than five years vs. 37 months in the control arm.
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Killer T cells surround a cancer cell.
Immuno-oncology

CLN-619 exerts antitumor activity in MICA/B-expressing tumors

May 23, 2025
No Comments
Major histocompatibility complex class I-related protein A and B (MICA and MICB) are ligands for the natural killer group 2 member D (NKG2D) receptor and are widely expressed on tumor cells, with very limited expression on normal tissues.
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Lab glassware and antibodies art concept
Immuno-oncology

Avenzo obtains IND clearance for EGFR/HER3 bispecific ADC AVZO-1418

May 23, 2025
No Comments
Avenzo Therapeutics Inc. has announced IND clearance by the FDA for AVZO-1418 (DB-1418), an EGFR/HER3 bispecific antibody-drug conjugate (ADC). A first-in-human phase I/II study will begin later this year and will evaluate AVZO-1418 as a single agent and in combination therapy in patients with advanced solid tumors.
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Ovarian cancer illustration
Immuno-oncology

Dual knockout of DGK-α and -ζ enhances TAG-72 CAR T-cell antitumor efficacy in ovarian cancer

May 22, 2025
No Comments
Ovarian cancer remains a leading cause of cancer-related deaths among women, with high recurrence rates and resistance to chemotherapy. CAR T-cell therapies present limited efficacy in solid tumors due to tumor heterogeneity and immune suppression in the tumor microenvironment.
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Immuneoncia Kosdaq debut

Cancer drug specialist Immuneoncia raises $24M in Kosdaq listing

May 21, 2025
By Marian (YoonJee) Chu
No Comments
Immuneoncia Therapeutics Inc. raised ₩33.9 billion (US$24 million) from its Kosdaq listing May 19. Shares closed at ₩7,500 – 108% higher than its offering price of ₩3,600 per share. Immuneoncia, a joint venture founded in 2016 between Seoul, South Korea-based Yuhan Corp. and San Diego-based Sorrento Therapeutics Inc., noted that the funds will support R&D operations until 2026.
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Floating antibody drug conjugates
Immuno-oncology

ALX Oncology presents preclinical data, plans for ALX-2004

May 21, 2025
No Comments
ALX Oncology Holdings Inc. is set to begin phase I studies around the middle of this year with ALX-2004, an antibody-drug conjugate (ADC) for the treatment of EGFR-expressing solid tumors, following IND clearance last month.
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3D Rendering of tumor microenvironment
Immuno-oncology

New oncolytic virus expressing FLT3L enhances antitumor immunity by activating dendritic cells

May 20, 2025
No Comments
Oncolytic viruses trigger immunogenic cell death in tumors, releasing signals that activate innate immune cells and promote tumor-specific T-cell responses. While some oncolytic viruses, including FDA-approved T-VEC, have shown safety and some clinical benefit, their limited effectiveness as standalone treatments underscores the need for combination therapies.
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CAR T cell attacking cancer cells
Immuno-oncology

PRGN-3008 exerts potent antitumoral activity and surpasses conventional CAR T

May 20, 2025
No Comments
CAR T-cell therapy for B-cell malignancies has still to be improved regarding durability, manufacturing complexity or toxicity, among others. Precigen Inc. has presented data regarding the preclinical development and efficacy of PRGN-3008, a PD-1-expression inhibitor cell therapy targeting CD19 that was built in a next-generation ultra CAR T platform.
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Illustration of dividing cancer cells
Immuno-oncology

New pyrrolo-pyridone inhibitor of Cbl-b against cancer

May 19, 2025
No Comments
Immune checkpoint inhibitors have revolutionized cancer therapy by reversing tumor-induced immunosuppression, but they fail to work for many patients because of resistance. In addition, they can reactivate immune pathways only from outside immune cells.
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3D rendering of an antibody drug conjugate
Immuno-oncology

Data support benefit of MUC1*-targeted ADCs in trastuzumab-resistant patients

May 19, 2025
No Comments
Minerva Biotechnologies Corp. recently released details on their work to develop a treatment for HER2-positive patients who have acquired resistance to Herceptin (trastuzumab) or Enhertu (trastuzumab-deruxtecan).
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