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Home » Topics » Drugs » Peptide

Peptide
Peptide RSS Feed RSS

Hengrui/Kailera obesity asset delivers solid weight loss in phase III

July 15, 2025
By Karen Carey
No Comments
A glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide receptor dual agonist developed by Jiangsu Hengrui Pharmaceuticals Co. Ltd. and licensed by Kailera Therapeutics Inc. has shown a mean weight loss of 19.2% at the 6-mg dose with no plateau over 48 weeks in a phase III trial conducted in China.
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Tape measure wrapped around feet on scale
Endocrine/metabolic

Triple agonist monomeric peptide shows distinct beneficial metabolic effects

July 14, 2025
No Comments
Single agonists of the glucagon-like peptide-1 receptor (GLP-1R) have been a success in the treatment of obesity, but monomeric dual or triple agonists have demonstrated improved efficacy on energy intake, appetite or metabolic function.
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Art concept for metabolism
Endocrine/metabolic

Oral dual GLP-1/glucagon receptor agonist peptide shows favorable preclinical profile

July 14, 2025
No Comments
Oxyntomodulin (OXM) is a peptide hormone released by intestinal L cells after food intake. It acts as a dual agonist of glucagon-like peptide 1 (GLP-1) and glucagon receptors, regulating appetite, energy expenditure and glucose metabolism. However, its short plasma half-life limits its therapeutic potential.
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Molecule illustration
Immune

Unnatural Products joins Argenx in a $1.5B macrocyclic deal

July 2, 2025
By Lee Landenberger
No Comments
Unnatural Products Inc. notched another collaboration by signing on with Argenx SE in a multitarget research collaboration. Unnatural Products, which is getting up-front, near-term payments and R&D funding, could end up with about $1.5 billion in milestones and options payments plus tiered royalties on net sales.
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Feet on scale and measuring tape
Endocrine/metabolic

Protagonist selects GLP-1/GIP/GCG receptor agonist peptide for obesity

July 2, 2025
No Comments
Protagonist Therapeutics Inc. has nominated PN-477 as a development candidate for the treatment of obesity.
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Molecule illustration

Unnatural Products joins Argenx in a $1.5B macrocyclic deal

July 1, 2025
By Lee Landenberger
No Comments
Unnatural Products Inc. notched another collaboration by signing on with Argenx SE in a multitarget research collaboration. Unnatural Products, which is getting up-front, near-term payments and R&D funding, could end up with about $1.5 billion in milestones and options payments plus tiered royalties on net sales.
Read More
Mazdutide injection device and product packaging

China clears mazdutide as first dual GCG/GLP-1RA for weight loss

June 30, 2025
By Marian (YoonJee) Chu
No Comments
Innovent Biologics Inc. announced June 27 that it gained National Medical Products Administration’s (NMPA) approval of mazdutide as a new weight loss therapy for obese or overweight patients in China. Mazdutide is a dual glucagon/glucagon-like peptide-1 (GCG/GLP-1) receptor agonist originally discovered by Eli Lilly and Co., of Indianapolis.
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Mazdutide injection device and product packaging

China clears mazdutide as first dual GCG/GLP-1RA for weight loss

June 30, 2025
By Marian (YoonJee) Chu
No Comments
Innovent Biologics Inc. announced June 27 that it gained National Medical Products Administration’s (NMPA) approval of mazdutide as a new weight loss therapy for obese or overweight patients in China. Mazdutide is a dual glucagon/glucagon-like peptide-1 (GCG/GLP-1) receptor agonist originally discovered by Eli Lilly and Co., of Indianapolis.
Read More
Elderly hands holding broken brain structure

Xpro phase II miss as Inmune’s Mindful tunes in to AD subgroup

June 30, 2025
By Randy Osborne
No Comments
Inmune Bio Inc. claimed a phase II win with TNF inhibitor Xpro (pegipanermin) in early Alzheimer’s disease (AD), though the study missed its primary and secondary endpoints, leading shares of the firm (NASDAQ:INMB) to close at $2.16, down $3.18, or almost 60%.
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Liver illustration

Altimmune’s phase IIb in MASH hits and misses, stock halves

June 26, 2025
By Lee Landenberger
No Comments
Top-line results from Altimmune Inc.’s phase IIb Impact study of pemvidutide in treating metabolic dysfunction-associated steatohepatitis showed the peptide-based GLP-1/glucagon dual receptor agonist hit one primary endpoint while not hitting statistical significance in another.
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