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Cancer

Janssen, J&J patents detail new menin/MLL interaction inhibitors for cancer

June 26, 2024
Janssen Pharmaceutica NV and Johnson & Johnson (China) Investment Ltd. patents disclose new menin (MEN1)/MLL interaction inhibitors reported to be useful for the treatment of cancer.
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Cancer

Gen1e Lifesciences discloses MAPK14 inhibitors

June 26, 2024
Gen1e Lifesciences Inc. has prepared new mitogen-activated protein kinase 14 (MAPK14; MAPK p38α) inhibitors reported to be useful for the treatment of cancer, inflammatory disorders, autoimmune diseases, viral infections, acute respiratory distress syndrome, amyotrophic lateral sclerosis, chronic obstructive pulmonary disease and cystic fibrosis.
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Cancer

Idorsia Pharmaceuticals identifies new CCR8 modulators

June 26, 2024
Research at Idorsia Pharmaceuticals Ltd. has led to the discovery of aryl- and heteroaryl-sulfonamide derivatives acting as C-C chemokine receptor type 8 (CCR8) antagonists.
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Dermatologic

Leo Pharma patents new IL-17 modulators

June 26, 2024
A Leo Pharma A/S patent describes new interleukin-17 (IL-17) modulators reported to be useful for the treatment of psoriasis, psoriatic arthritis, and radiographic axial spondyloarthritis (ankylosing spondylitis), among other diseases.
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Neurology/psychiatric

CNRS, University of Strasbourg jointly develop oxytocin receptor agonists

June 26, 2024
The Centre National de la Recherche Scientifique (CNRS) and the University of Strasbourg have patented nonpeptidergic oxytocin receptor agonists potentially useful for the treatment of aging, alcoholism, pain and more.
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Illustration of thymus in relation to lungs and thyroid
Immune

Fibrobiologics’ artificial thymus organoid restores immune function in SCID mouse model

June 26, 2024
Fibrobiologics Inc. has announced the development of a novel artificial thymus organoid that can restore immune function in a severe combined immunodeficiency (SCID) mouse model.
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Drug discovery illustration
Cancer

PA2G4-MYC signaling axis involved in pathogenesis of 3q26 AML, study shows

June 26, 2024
The treatment of subtypes of acute myeloid leukemia (AML) characterized by aberrantly activated transcription factors is still challenging.
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Immuno-oncology

Blimp-1 ablation enhances antitumoral efficacy of ARI-0002-h CAR T cells

June 26, 2024
CAR T-cell therapy that targets BCMA is an effective option for treating relapsed/refractory multiple myeloma, but there is a lack of persistence due to the inability to develop a memory phenotype.
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Multiple myeloma illustration
Immuno-oncology

CSPC’s mRNA-LNP-based CAR T-cell therapy cleared to enter clinic in China for multiple myeloma

June 26, 2024
CSPC Pharmaceutical Group Ltd. has obtained clearance from China’s National Medical Products Administration (NMPA) to conduct clinical trials in China with the first mRNA-lipid nanoparticles (LNP)-based CAR T-cell injection, SYS-6020.
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Musculoskeletal

Astrazeneca’s AZD-1163 inhibits autoantigen production in rheumatoid arthritis

June 26, 2024
The generation of anti-citrullinated protein autoantibodies (ACPA) are known key drivers in the pathogenesis of rheumatoid arthritis (RA) and are generated by peptidyl arginine deiminases (PADs).
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