Glucose-dependent insulinotropic polypeptide receptor (GIPR) signaling regulates key metabolic processes, including postprandial insulin secretion, appetite control, lipid storage and overall energy balance. Researchers from Antag Therapeutics Aps presented preclinical efficacy data on the combination of AT-7687, a GIPR antagonist, and cagrilintide in obese insulin-resistant monkeys.
JW Pharmaceutical Corp. has presented data on DDC-02 across animal models of several rare neurodevelopmental disorders, including Pitt-Hopkins syndrome, fragile X syndrome and Rett syndrome. Across these models, DDC-02 consistently restored deficits in cognitive and behavioral function.
Insulin-like growth factor 2 mRNA binding protein 3 (IGF2BP3) is an oncofetal RNA-binding protein aberrantly overexpressed in multiple cancers, where it promotes tumor growth by stabilizing oncogenic mRNAs. Researchers at the University of California described the efficacy of I3IN-002, a potent IGF2BP3 inhibitor, in leukemia models.
Former principal officers of the American Diabetes Association (ADA) have hit back at the association’s board and CEO after it prohibited the distribution of an editorial published in its flagship journal Diabetes Care at the ADA’s meeting in New Orleans last Friday.
Shanghai Helioson Pharmaceutical Co. Ltd. has patented molecular glue degraders comprising cereblon (CRBN) binding agents acting as proto-oncogene Vav (VAV1) degradation inducers found to be potentially useful for the treatment of autoimmune disease and cancer.
Shenzhen Salubris Pharmaceuticals Co. Ltd. has synthesized relaxin family peptide receptor 1 (RXFP1) receptor agonists reported to be potentially useful for the treatment of heart failure.
Shanghai Qingrun Pharmaceutical Technology Co. Ltd. has disclosed new S-adenosylmethionine synthase isoform type-2 (Mat2A) inhibitors that are potentially useful for the treatment of cancer.
Innovo Therapeutics Inc. has divulged sulfonamide derivatives acting as N-myristoyltransferase 1 (NMT1) inhibitors found to be potentially useful for the treatment of cancer, protozoal and viral infection.
Leto Laboratories Co. Ltd. has identified macro cyclic peptides acting as calcitonin receptor (CALCR; CT-R) and amylin dual receptor agonists reported to be potentially useful for the treatment of atherosclerosis, type 1 diabetes, dyspepsia, myocardial infarction, obesity and more.
Ubiquitin-specific protease 7 (USP7) is a central regulator of multiple oncogenic pathways and is associated with tumor aggressiveness and poor prognosis across several cancer types. Researchers from Molecure SA characterized the preclinical profile of OAT-4828, a selective USP7 inhibitor with antiproliferative activity.
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