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Illustration of hole in vessel wall with repair process in progress
Hematologic

SV-003 restores coagulation in the preclinical setting

June 25, 2025
No Comments
Bispecific antibodies mimicking coagulation factor VIIIa (FVIIIa) have yielded successful results in the treatment of hemophilia A, but there remain some issues in regard to their production.
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Female scientist looking through microscope
Endocrine/metabolic

Supercede’s SPCD-4-79 demonstrates preclinical efficacy in DIO mice

June 25, 2025
No Comments
Supercede Therapeutics Inc. has released preclinical efficacy data on its small-molecule inhibitor of the Activin receptor type II (ACTRII) to treat obesity.
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T cells
Immune

Cue Biopharma holds pre-IND meeting with FDA for lead autoimmune asset

June 25, 2025
No Comments
Cue Biopharma Inc. has received pre-IND feedback from the FDA to discuss the proposed development plan for CUE-401, its lead autoimmune asset. Based on FDA feedback, the company intends to file an IND pending completion of final IND-enabling studies.
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Cancer

New CAIX-targeting 68Ga/177Lu theranostic pair for clear cell renal cell carcinoma

June 25, 2025
No Comments
At the recent meeting of the Society of Nuclear Medicine and Molecular Imaging, Chinese Academy of Medical Sciences and Peking Union Medical College scientists co-presented a carbonic anhydrase IX (CAIX)-targeting 68Ga/177Lu theranostic pair for clear cell renal cell carcinoma (ccRCC) and its preclinical evaluation.
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Holiday notice

June 25, 2025
In accordance with the publishing schedule, BioWorld Science was not published on Tuesday, June 24, 2025.
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Free access to BioWorld coronavirus articles

June 24, 2025
The articles in this collection are from BioWorld’s ongoing coverage of the COVID-19 coronavirus pandemic. They are available for free with registration. Note that we have added three critical tables, which are continuously updated:

Vaccines and therapeutics in development
Diagnostics with U.S. FDA emergency use authorization
Clinical trials of biopharma products affected by COVID-19
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Other news to note for June 23, 2025

June 23, 2025
Additional early-stage research and drug discovery news in brief, from: Cancervax, Metavia, Neurizon Therapeutics, Wave Life Sciences.
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Holiday notice

June 23, 2025
In accordance with the publishing schedule, BioWorld Science will not be published on Tuesday, June 24, 2025.
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Neurology/psychiatric

Nura Bio identifies new TREM2 agonists

June 23, 2025
Nura Bio Inc. has patented new bicyclic heteroaryl compounds acting as triggering receptor expressed on myeloid cells 2 (TREM2) agonists.
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Cancer

PRMT5 reported in Chia Tai Tianqing Pharmaceutical patent

June 23, 2025
Work at Chia Tai Tianqing Pharmaceutical Group Co. Ltd. has led to the identification of new protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.
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