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Neurology/psychiatric

Biosplice Therapeutics patents new DYRK1A inhibitors for Alzheimer’s disease

July 16, 2025
Biosplice Therapeutics Inc. has prepared and tested 4-alkoxypyrrolo[2,1-F][1,2,4]triazines acting as dual specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A) inhibitors potentially useful for the treatment of Alzheimer’s disease.
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Neurology/psychiatric

Atai Therapeutics discovers new 5-HT2A receptor partial agonists

July 16, 2025
Atai Therapeutics Inc. has synthesized new tetrahydro pyridine-substituted indole and azaindoles acting as 5-HT2A receptor partial agonists reported to be useful for the treatment of psychiatric disorders.
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Scientist, microscope and dropper
Cancer

Chinese researchers develop potent piperine derivative for breast cancer

July 16, 2025
No Comments
Dysfunction of the tumor suppressor p53, commonly resulting from MDM2 overexpression or gene mutations, plays a key role in breast cancer progression. While the bioactive compound piperine has been shown to enhance p53 activity, its clinical utility is limited by poor bioavailability, potential toxicity and the risk of adverse drug interactions.
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Kidney illustration
Nephrology

CAF22 serves as a diagnostic marker of hypertensive nephropathy

July 16, 2025
No Comments
Hypertensive nephropathy is a major complication of hypertension characterized by inflammation and fibrosis in the kidneys. Recent findings have suggested that agrin may play a critical role in some tissue types such as in the heart or skeletal muscle.
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Antibodies attacking cancer cell
Cancer

DS-3939a ADC for treating TA-MUC1-expressing tumors

July 16, 2025
No Comments
Antibody-drug conjugates (ADCs) are therapeutics that combine an antibody with a cytotoxic payload via a chemical linker to specifically target certain cells. Tumor-associated mucin-1 (TA-MUC1) is a glycosylated form of the MUC1 protein that is expressed in several cancer cells, thus being an interesting target for ADC development.
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Endocrine/metabolic

RT-114 robotic capsule matches injectable PG-102 in preclinical study

July 16, 2025
No Comments
Incretin-based therapies have demonstrated substantial efficacy in the treatment of metabolic diseases such as obesity and type 2 diabetes but the need for frequent injections remains a major barrier to patient adherence and comfort.
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Optogenetics illustration
Ocular

Aavantgarde Bio cleared to begin clinical study of Stargardt disease gene therapy in US

July 16, 2025
No Comments
The U.S. FDA has cleared Aavantgarde Bio Srl’s IND application for AAVB-039, the company’s gene therapy program for Stargardt disease, the most common inherited form of macular degeneration.
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Elderly woman holding illustration of brain with missing puzzle piece
Neurology/psychiatric

Acumen and JCR enter collaboration to develop BBB-penetrating Alzheimer’s treatment

July 16, 2025
No Comments
Acumen Pharmaceuticals Inc. and JCR Pharmaceuticals Co. Ltd. have entered a collaboration, option and license agreement to develop a novel therapeutic candidate for the treatment of Alzheimer’s disease (AD).
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Doctor measuring patient's waist
Endocrine/metabolic

Palatin Technologies reports efficacy of PL-7737 in obesity model

July 16, 2025
No Comments
Palatin Technologies Inc. has announced preclinical results for PL-7737, an oral selective melanocortin MC4 receptor (MC4R) agonist, showing effectiveness in rodent models of obesity.
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Transmission electron micrograph of HIV-1 virus particles
HIV/AIDS

IAS 2025: All eyes still on the HIV reservoir

July 16, 2025
By Mar de Miguel
No Comments
While people living with HIV can lead virtually normal lives thanks to antiretroviral therapy (ART), HIV persists in a latent state within cellular reservoirs that scientists do not know how to eliminate. “Transcription is a critical step in the viral life cycle. … But there are currently no drugs suppressing HIV transcription, and that may be one of the reasons why current antiretroviral therapy is not curative,” Melanie Ott told the audience at the 13th IAS Conference on HIV Science this week in Kigali, Rwanda.
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