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BioWorld - Sunday, February 5, 2023
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Cancer

CARM1 cooperates with NFIB to promote SCLC development

Feb. 1, 2023
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Coactivator-associated arginine methyl...
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Microscopic image of acute myeloid leukemia (AML) cells.
Immuno-oncology

Bivictrix reports promising in vivo data with BVX-001 in CD34-boosted humanized murine model

Feb. 1, 2023
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Bivictrix Therapeutics plc has released promising...
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Immuno-oncology

Transcode reports preclinical proof-of-mechanism study results with immunotherapy TTX-RIGA

Feb. 1, 2023
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Transcode Therapeutics Inc. has conducted...
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Non-Hodgkin lymphoma cells in the blood flow
Cancer

RS-6077, a tubulin polymerization inhibitor with antitumor activity in models of lymphoma

Feb. 1, 2023
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Researchers from Sapienza University of Rome...
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3d illustration of ovarian cancer
Cancer

Novel potent BRD4/NO hybrid shows superior antitumor activity in ovarian cancer models

Feb. 1, 2023
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Researchers from West China Hospital, Sichuan...
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Chatbot icon made with binary code.
Drug Design, Drug Delivery & Technologies

Chatbot methodology learns to make proteins

Feb. 1, 2023
By Anette Breindl
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Researchers have developed an algorithm that was able to create functional enzymes from scratch after being trained with the amino acid sequences of existing enzymes in the same class. Researchers from the University of California at San Francisco described their method online in Nature Biotechnology on Jan. 26, 2023. The method, which its creators have named Progen, can generate “protein sequences with a predictable function across large protein families,” according to the authors.
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Cholesterol plaque in artery
Cardiovascular

T-cell study reveals autoimmune component of atherosclerosis

Jan. 31, 2023
By Mar de Miguel
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The combination of two sequencing techniques has unveiled features of a subpopulation of cells that could be producing plaques in atherosclerosis. This process is associated with an autoimmune component driven by CD4+ T cells, according to a study from researchers at Leiden University.

“I think that we can clearly say now that atherosclerosis is a very clear autoimmune component. It is a multifactorial disease, a combination of genes, and lifestyle, but also inflammation and the immune system,” Ilze Bot and Bram Slütter, associate professors at the Division of Biotherapeutics of Leiden University, told BioWorld.
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Other news to note for Jan. 31, 2023

Jan. 31, 2023
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Additional early-stage research and drug discovery news in brief, from: Alterity Therapeutics, Sernova.
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Cancer

Alphamab (Jiangsu) Biopharmaceuticals presents new HER2-targeting ADCs

Jan. 31, 2023
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Alphamab (Jiangsu) Biopharmaceuticals Co. Ltd. has identified new antibody-drug conjugate (ADC) comprising bispecific antibodies targeting HER2 covalently bound to cytotoxic drugs through a linker reported to be useful for the treatment of cancer.
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Cancer

Hinova Pharmaceuticals identifies new PTPN11-targeting PROTACs

Jan. 31, 2023
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Hinova Pharmaceuticals Inc. has presented proteolysis targeting chimera (PROTAC) compounds comprising E3 ubiquitin ligase-binding moiety covalently linked to tyrosine-protein phosphatase nonreceptor type 11 (PTPN11)-targeting moiety through a linker reported to be useful for the treatment of cancer, Noonan and LEOPARD syndromes.
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