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Infection

Gilead Sciences divulges new compounds to treat herpes virus infection

June 6, 2025
Gilead Sciences Inc. has synthesized indoline compounds acting as DNA helicase-primase complex (human herpes simplex virus) and viral replication inhibitors reported to be useful for the treatment of herpes virus infection.
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Dermatologic

Biogen patents new TYK2 inhibitors

June 6, 2025
Biogen Inc. has disclosed non-receptor tyrosine-protein kinase TYK2 inhibitors reported to be useful for the treatment of stroke, psoriasis, arthritis, pain, silicosis, alopecia and more.
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Elderly woman holding illustration of brain with missing puzzle piece
Neurology/psychiatric

Grant supports Mindimmune’s development of MITI-101 for Alzheimer’s disease

June 6, 2025
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Mindimmune Therapeutics Inc. has been awarded a grant by Rhode Island Life Science Hub to accelerate preclinical development work on MITI-101 for the treatment of mild to moderate Alzheimer’s disease. The award will accelerate development work needed to start first-in-human studies.
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Cancer

EMA’s COMP recommends orphan drug designation for Hemispherian’s GLIX-1 for glioma

June 6, 2025
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The EMA’s Committee for Orphan Medicinal Products (COMP) has issued a positive opinion recommending European orphan drug designation for Hemispherian AS’s GLIX-1 for the treatment of glioma.
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Man with respiratory issues
Respiratory

Seyltx enters option agreement to in-license Neurop’s GluN2B antagonists for chronic cough

June 6, 2025
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Seyltx Inc. has entered into an option agreement with Neurop Inc. for a portfolio of novel GluN2B antagonists. The compounds include NP-10679, which has completed phase I, and seven preclinical candidates.
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Illustration of brain receptors with their neurotransmitters
Neurology/psychiatric

New GluN1/GluN3A NMDA receptor inhibitors based on AI

June 6, 2025
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Scientists at Shanghai Tech University have used the scaffold-hopping artificial intelligence model Geminimol to identify N-methyl-D-aspartate (NMDA) receptor ligands that show selectivity and specificity. The researchers found that GM-10 could be a potent inhibitor of the GluN1/GluN3A subunits of the NMDA receptor, demonstrating the utility of this technique to develop new drugs.


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Neurology/psychiatric

Solvonis completes synthesis of development candidates for SVN-SDN-014 program

June 6, 2025
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Solvonis Therapeutics plc has completed synthesis of development candidates for its SVN-SDN-014 program, a novel series of serotonin, dopamine and noradrenaline modulators.
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Structural model of dengue virus.
Immune

Immunoprecise Antibodies discovers highly conserved epitope across all four dengue virus serotypes

June 6, 2025
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Immunoprecise Antibodies Ltd. has discovered a highly conserved epitope across all four dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) using its proprietary Lensai platform powered by its Hyft technology.
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Neurology/psychiatric

Chinese researchers disclose a selective, non-irritant TRPA1 agonist for pain relief

June 6, 2025
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Using agonists to desensitize the homotetrameric transient receptor potential ankyrin 1 (TRPA1) channel is a validated strategy for pain relief.
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Close up image of shoulder and back with severe urticaria or hives
Dermatologic

Aqilion reports results for TAK1 program in skin inflammation studies

June 6, 2025
No Comments
Aqilion AB has released promising results from new studies with molecules from the company’s lead series within the TAK1 program, demonstrating a strong disease-modifying effect in a well-established model of skin inflammation.
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