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Cancer

Ideaya Biosciences patents KAT6A and KAT7 inhibitors

July 18, 2025
Compounds acting as histone acetyltransferase KAT6A (MOZ; MYST-3) and KAT7 (HBO-1; MYST-2) inhibitors are reported in an Ideaya Biosciences Inc. patent as potentially useful for the treatment of cancer.
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Cancer

Deciphera Pharmaceuticals patent details compounds for treatment of cancer

July 18, 2025
Deciphera Pharmaceuticals LLC has described new dual serine/threonine-protein kinase B-Raf (BRAF) and/or RAF proto-oncogene serine/threonine-protein kinase (RAF1; c-Raf) and microtubule destabilizers (tubulin polymerization inhibitors) potentially useful for the treatment of cancer.
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Endocrine/metabolic

Gasherbrum Bio reports new GLP-1R agonists for diabetes

July 18, 2025
Gasherbrum Bio Inc. has patented new heterocyclic glucagon-like peptide 1 receptor (GLP-1R) agonists reported to be useful for the treatment of type 2 diabetes, among others.
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Cancer

Oncolytic herpes simplex virus expressing interleukin-27 to treat gliomas

July 18, 2025
No Comments
Malignant gliomas, which include glioblastomas, are the most frequent primary brain cancer and are associated with extremely poor prognosis. They nearly always recur after treatment, rapidly leading to death.
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Microscope and coronavirus illustration
Infection

Results of ADME study of the small-molecule 3CLpro inhibitor SHEN-211

July 18, 2025
No Comments
SHEN-211 is a selective 3-chymotrypsin-like protease (3CLpro) inhibitor that can protect against SARS-CoV-2. In previous work, SHEN-211 demonstrated high efficacy in inhibiting 3CLpro (IC50=24 nM) and exhibited broad-spectrum antiviral properties.
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Lung cancer illustration
Immuno-oncology

Nanobody against CD155 to treat lung cancer

July 18, 2025
No Comments
Lung cancer is the most frequent cause of cancer-related death in both men and women worldwide. Current treatments can fail because of variable responses in different types of patients, drug resistance, poor tumor penetration and systemic toxicity, prompting the continuing search for better therapeutics.
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Concept art for targeting cancer
Cancer

Spliceosome RNPC3 blockade restricts the growth of several cancer types

July 18, 2025
No Comments
Splicing is a process necessary for the correct synthesis of proteins and an essential step in gene expression. An impaired minor splicing may lead to aberrant pre-mRNA transcripts and exon skipping, leading to premature stop codons and truncated synthesized proteins, resulting in severe consequences.
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Cardiovascular

Bi-allelic variants in POPDC2 cause cardiac conduction defects

July 18, 2025
No Comments
Researchers have identified bi-allelic variants in the POPDC2 gene as the cause of a rare inherited cardiac syndrome characterized by sinus node dysfunction, atrioventricular (AV) conduction defects and hypertrophic cardiomyopathy.
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Woman and molecular overlay
Endocrine/metabolic

Research shows d3-T has testosterone benefits without estradiol conversion

July 18, 2025
No Comments
In drug development, replacing hydrogen atoms with deuterium may help improve the pharmacokinetic profile without altering pharmacodynamic activity.
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Cancer

New vulnerability in uveal melanoma opens door to treatment advances

July 18, 2025
No Comments
In a recent study published in Nature Genetics, a team of scientists used CRISPR-Cas9 gene editing to systematically analyze genetic weaknesses in uveal melanoma cells and comprehensively map monogenic and digenic dependencies.
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