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BioWorld - Wednesday, February 1, 2023
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Cancer

Janssen Pharmaceutica describes new NLRP3 inflammasome inhibitors

Jan. 27, 2023
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Janssen Pharmaceutica NV has identified 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides acting as NLRP3 inflammasome inhibitors reported to be useful for the treatment of cancer, viral hepatitis, diabetes, immunological, inflammatory, neurological, cardiovascular and metabolic disorders.
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Cancer

Medshine Discovery divulges new MAPK3 and MAPK1 inhibitors for cancer

Jan. 27, 2023
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Medshine Discovery Inc. has synthesized dimethyl-substituted thiazololactam compounds acting as mitogen-activated protein kinase 3 (MAPK3; ERK1) and/or (MAPK1; ERK2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Researchers patent new androgen receptor antagonists for prostate cancer

Jan. 27, 2023
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Shanghai University of Traditional Chinese Medicine and Vestlandets Innovasjonsselskap AS (VIS) have disclosed bufalin derivatives acting as androgen receptor antagonists reported to be useful for the treatment of prostate cancer.
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Drug Design, Drug Delivery & Technologies

Genkore establishes collaboration on in vivo gene editing therapies

Jan. 27, 2023
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Genkore Inc. has entered into a strategic research collaboration with a U.S.-based biopharma company for the development of in vivo gene editing therapies.
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Colorful illustration of the heart
Biomarkers

Plasmatic GAS6 levels predict acute heart failure mortality risk

Jan. 27, 2023
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Heart failure still remains a leading cause of death worldwide. Improving risk stratification and prognostic analysis tools is required to aid in the management of the disease.
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Immuno-oncology

Sana receives IND clearance for CAR T-cell therapy SC-291 for B-cell malignancies

Jan. 27, 2023
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Sana Biotechnology Inc. has received FDA clearance of its IND application to initiate a first-in-human study of SC-291 in patients with various B-cell malignancies. Initial clinical data from the study are expected later this year. SC-291 is a CD19-targeted allogeneic chimeric antigen receptor (CAR) T-cell therapy developed using Sana's hypoimmune platform.
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Gastrointestinal

Exegi Pharma cleared to study EXE-346 for management of IPAA patients

Jan. 27, 2023
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Exegi Pharma LLC has received FDA clearance of its IND application for EXE-346, allowing the company to initiate a clinical trial to evaluate EXE-346 in the management of excessive stool frequency in patients with an ileal pouch-anal anastomosis (IPAA, J-Pouch).
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Brain and DNA
Neurology/Psychiatric

Herophilus conducts in vivo studies of HRP-12975 for Rett syndrome

Jan. 27, 2023
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Herophilus Inc. is conducting in vivo studies of lead candidate HRP-12975, a small-molecule therapy for Rett syndrome, with funding from the Rett Syndrome Research Trust. The company is generating efficacy and safety data with HRP-12975 using genetic mouse models of Rett syndrome.
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Inflammatory

Novel anti-inflammatory compound alleviates LPS-induced acute lung injury in vivo

Jan. 27, 2023
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Researchers from Wenzhou Medical University and affiliated organizations have reported the discovery and preclinical evaluation of novel anti-inflammatory compounds. Synthesis and optimization of a new series of 1-(4-(benzylsulfonyl)-2-nitrophenyl) derivatives resulted in the identification of compound [I] as the lead candidate.
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Illustration of antibodies attacking nerve cells
Neurology/Psychiatric

Lapix receives support from FDA for IND-enabling plan for LPX-TI641

Jan. 27, 2023
No Comments
Lapix Therapeutics Inc. has announced the successful outcome of its pre-IND meeting request with the FDA to achieve alignment on the company's IND-enabling plan for LPX-TI641, being developed for neuro-autoimmune indications such as multiple sclerosis (MS), neuromyelitis optica spectrum disorders (NMOSD), and myelin oligodendrocyte glycoprotein antibody disease (MOGAD).
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