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Cancer

Blossomhill Therapeutics patents ALK tyrosine kinase receptor inhibitors

June 27, 2025
Blossomhill Therapeutics Inc. has synthesized new indazole-based macrocyclic compounds acting as ALK tyrosine kinase receptor inhibitors potentially useful for the treatment of cancer.
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Neurology/psychiatric

Atai Therapeutics discloses new 5-HT2A receptor agonists

June 27, 2025
Atai Therapeutics Inc. has patented new 5-HT2A receptor agonists reported to be useful for the treatment of substance abuse and dependence, treatment-resistant depression, major depression, anxiety, eating, obsessive-compulsive and stress disorder.
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3D illustration of leishmania parasite
Infection

Discovery and evaluation of new indole-dihydropyrimidinone derivatives for visceral leishmaniasis

June 27, 2025
No Comments
Visceral leishmaniasis is a fatal disease caused by the Leishmania parasite, affecting organs such as the liver and spleen. Visceral leishmaniasis is considered a neglected tropical disease and is estimated to cause between 50,000 and 90,000 cases and around 70,000 deaths per year.
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3D illustration of cancer in crosshairs
Cancer

HS-1002 boosts T-cell function, synergizes with PD-1 blockade in cancer models

June 27, 2025
No Comments
T-cell activity is often suppressed by the immunosuppressive nature of the tumor microenvironment, contributing to the limited efficacy of many immunotherapeutic strategies. Treatment with peptides derived from human telomerase reverse transcriptase (hTERT) has been shown to effectively promote the expansion and activation of effector T cells, thereby enhancing antitumor immunity.
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Endocrine/metabolic

OB-756 shows therapeutic efficacy in type 1 diabetes

June 27, 2025
No Comments
The main feature of type 1 diabetes is the destruction of pancreatic β cells that produce insulin. Immunotherapy directed at inhibiting immune interactions between cytokines and islet cells and preserving its functioning is key to reverse the progression of the disease.
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Heart with blocked arteries
Endocrine/metabolic

IBI-3030 protects against cardiovascular risk in mice

June 27, 2025
No Comments
IBI-3030 from Innovent Biologics Inc. is a novel antibody-peptide conjugate targeting PCSK9 that shows agonism for GLP-1R, GCGR and GIPR, aimed to confer therapeutic benefit against cardiovascular disease.
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Cancer

UD-086, a next-generation HER2-targeting ADC with enhanced therapeutic index

June 27, 2025
No Comments
Despite the approval of numerous antibody-drug conjugates (ADCs), their therapeutic index remains limited by off-target toxicity resulting from linker instability. To address this challenge, the development of novel ADCs with improved plasma stability and reduced systemic toxicity is critically needed.
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Art concept for monoclonal antibodies
Hematologic

Hemab presents data for HMB-002 in von Willebrand disease

June 27, 2025
No Comments
Hemab ApS recently presented preclinical data on its human monoclonal antibody against von Willebrand factor (vWF), HMB-002, for the treatment of von Willebrand disease.
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Illustration of T cells attacking tumor
Immuno-oncology

CDR-Life unveils T-cell engager targeting LGR5 as clinical candidate

June 27, 2025
No Comments
CDR-Life Inc. has announced CDR-609 as its next clinical candidate. Built on the company’s proprietary M-gager platform, CDR-609 is a novel T-cell engager targeting LGR5, a surface antigen widely expressed on common solid tumors, including colorectal, gastric, liver and pancreatic cancers.
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Illustration of the β2-adrenergic receptor
Endocrine/metabolic

Exercise-mimicking compound offers alternative to GLP-1 therapies

June 27, 2025
By Mar de Miguel
No Comments
An experimental drug for treating diabetes and obesity has been shown to lower blood sugar levels and increase fat burning. It is a β2-adrenergic receptor (β2AR) agonist that mimics the effects of physical exercise by activating skeletal muscle metabolism. Unlike GLP-1-based treatments such as semaglutide and tirzepatide, this new compound, developed by researchers at the Karolinska Institute, Stockholm University, and the biotech company Atrogi AB, does not suppress appetite or cause muscle loss. 
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