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Other news to note for June 27, 2025

June 27, 2025
Additional early-stage research and drug discovery news in brief, from: Enveric Biosciences, Fractyl Health, Inmed Pharmaceuticals, Inventprise.
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Handshake with digital globe overlay

Abion strikes $1.3B antibody drug deal with unidentified partner

June 27, 2025
By Marian (YoonJee) Chu
No Comments
Abion Inc. signed a potential $1.315 billion deal with an anonymous partner June 22, granting the counterparty exclusive global rights to a preclinical claudin 3-targeting monoclonal antibody, ABN-501, and the potential to license four more protein targeting antibodies.
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Cancer

Bristol Myers Squibb patent details new GTPase KRAS mutant inhibitors

June 27, 2025
Bristol Myers Squibb Co. has identified new GTPase KRAS (G12C mutant) inhibitors reported to be useful for the treatment of cancer.
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Neurology/psychiatric

Muscarinic M4 receptor positive allosteric modulators reported in Acadia Pharmaceuticals patent

June 27, 2025
Muscarinic M4 receptor positive allosteric modulators are detailed in an Acadia Pharmaceuticals Inc. patent. They are reported to be useful for the treatment of Alzheimer’s disease, pain, schizophrenia, Huntington’s disease, Parkinson’s disease, psychosis and drug abuse and dependence.
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Neurology/psychiatric

Genep discovers new Nav1.6 blockers

June 27, 2025
Genep Inc. has prepared and tested Imidazole compounds acting as sodium channel protein type 8 subunit α (SCN8A; Nav1.6) blockers reported to be useful for the treatment of epilepsy.
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Cancer

Blossomhill Therapeutics patents ALK tyrosine kinase receptor inhibitors

June 27, 2025
Blossomhill Therapeutics Inc. has synthesized new indazole-based macrocyclic compounds acting as ALK tyrosine kinase receptor inhibitors potentially useful for the treatment of cancer.
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Neurology/psychiatric

Atai Therapeutics discloses new 5-HT2A receptor agonists

June 27, 2025
Atai Therapeutics Inc. has patented new 5-HT2A receptor agonists reported to be useful for the treatment of substance abuse and dependence, treatment-resistant depression, major depression, anxiety, eating, obsessive-compulsive and stress disorder.
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3D illustration of leishmania parasite
Infection

Discovery and evaluation of new indole-dihydropyrimidinone derivatives for visceral leishmaniasis

June 27, 2025
No Comments
Visceral leishmaniasis is a fatal disease caused by the Leishmania parasite, affecting organs such as the liver and spleen. Visceral leishmaniasis is considered a neglected tropical disease and is estimated to cause between 50,000 and 90,000 cases and around 70,000 deaths per year.
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3D illustration of cancer in crosshairs
Cancer

HS-1002 boosts T-cell function, synergizes with PD-1 blockade in cancer models

June 27, 2025
No Comments
T-cell activity is often suppressed by the immunosuppressive nature of the tumor microenvironment, contributing to the limited efficacy of many immunotherapeutic strategies. Treatment with peptides derived from human telomerase reverse transcriptase (hTERT) has been shown to effectively promote the expansion and activation of effector T cells, thereby enhancing antitumor immunity.
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Endocrine/metabolic

OB-756 shows therapeutic efficacy in type 1 diabetes

June 27, 2025
No Comments
The main feature of type 1 diabetes is the destruction of pancreatic β cells that produce insulin. Immunotherapy directed at inhibiting immune interactions between cytokines and islet cells and preserving its functioning is key to reverse the progression of the disease.
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