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BioWorld - Saturday, July 19, 2025
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Man piecing together a puzzle
Neurology/psychiatric

VU-0810464 improves synaptic plasticity and memory impairment in Alzheimer’s disease

July 14, 2025
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A team of researchers from the University of Castilla-La Mancha, Spain, further investigated the link between hippocampal G protein-activated inward rectifier potassium channel (GIRK) and Alzheimer’s disease pathology.
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Creative rendition of SARS-CoV-2 virus particles.
Infection

New mRNA vaccine demonstrates preclinical activity against emerging SARS-CoV-2 variants

July 14, 2025
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As of May 2023, the WHO recommends the use of a monovalent XBB.1 descendent lineage, such as omicron XBB.1.5, as the vaccine antigen for COVID-19 vaccines. However, BA.2.86 and its descendent lineages, such as JN.1, have emerged and rapidly spread worldwide.
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Tape measure wrapped around feet on scale
Endocrine/metabolic

Triple agonist monomeric peptide shows distinct beneficial metabolic effects

July 14, 2025
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Single agonists of the glucagon-like peptide-1 receptor (GLP-1R) have been a success in the treatment of obesity, but monomeric dual or triple agonists have demonstrated improved efficacy on energy intake, appetite or metabolic function.
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Art concept for metabolism
Endocrine/metabolic

Oral dual GLP-1/glucagon receptor agonist peptide shows favorable preclinical profile

July 14, 2025
No Comments
Oxyntomodulin (OXM) is a peptide hormone released by intestinal L cells after food intake. It acts as a dual agonist of glucagon-like peptide 1 (GLP-1) and glucagon receptors, regulating appetite, energy expenditure and glucose metabolism. However, its short plasma half-life limits its therapeutic potential.
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Respiratory

New oral BRD4 inhibitor blocks pathogenic expansion of epithelial progenitors in IPF models

July 14, 2025
No Comments
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease with limited treatment options. IPF is thought to result from repeated microinjuries to aging lung tissue, triggering dysfunctional repair responses that drive fibrosis and respiratory failure. Researchers from the University of Wisconsin Madison and the University of Texas Medical Branch have now identified a potential new therapeutic approach for IPF by targeting bromodomain-containing protein 4 (BRD4).
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Scientific figure illustrating astrocytes and neuron synapse
Neurology/psychiatric

Glia 2025: Microglial crosstalk could be early Alzheimer’s targeting opportunity

July 14, 2025
By Anette Breindl
No Comments
“Loss of synapses and dysfunctional synapses in a region-specific way is important in Alzheimer’s. It’s actually the strongest correlate of cognitive decline, far more so than plaques and tangles, which are the pathological hallmarks,” Soyon Hong told the audience at the XVII Meeting on Glial Cells in Health and Disease, which was held in Marseille last week.
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Best of BioWorld Science: Q2

July 14, 2025
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A selection of top research news from April through June 2025.
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Other news to note for July 11, 2025

July 11, 2025
Additional early-stage research and drug discovery news in brief, from: Nurexone Biologic, Silexion Therapeutics, Tonix Pharmaceuticals.
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Cancer

Actithera raises $75M series A for FAP-targeted radiopharmaceuticals

July 11, 2025
By Nuala Moran
No Comments
Actithera A/S is poised to bring small-molecule pharmacokinetics to radiopharmaceuticals after closing a $75.5 million series A that will fund initial clinical development of a candidate targeting the elusive fibroblast activation protein (FAP).
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Neurology/psychiatric

Regulonix and US HHS discover new Nav1.7 blockers for neuropathic pain

July 11, 2025
Regulonix LLC and the U.S. Department of Health and Human Services (HHS) have jointly patented new sodium channel protein type 9 subunit α (SCN9A; Nav1.7) blockers reported to be useful for the treatment of neuropathic pain.
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