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BioWorld - Monday, February 6, 2023
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Other news to note for Jan. 30, 2023

Jan. 30, 2023
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Additional early-stage research and drug discovery news in brief, from: Salarius Pharmaceuticals.
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3D illustration showing tumor inside prostate gland and closeup view of cancer cells
Biomarkers

Altered plasma proteins tied to progression in castration-resistant prostate cancer

Jan. 27, 2023
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Androgen deprivation therapy (ADT) is still the main treatment option for locally advanced and metastatic prostate cancer (PCa); however, most patients receiving ADT develop resistance to treatment and relapse, with a more aggressive form of cancer, castration-resistant prostate cancer (CRPC).
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Endocrine/Metabolic

HBM Alpha completes seed financing to advance programs for congenital adrenal hyperplasia and PCOS

Jan. 27, 2023
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HBM Alpha Therapeutics Inc. has completed seed financing to advance its lead programs, novel antibody therapies to treat congenital adrenal hyperplasia (CAH) and polycystic ovary syndrome (PCOS).
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Antibodies attacking cancer cell
Immuno-oncology

Centessa to advance conditionally tetravalent PD-L1xCD47 bispecific monoclonal antibody

Jan. 27, 2023
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Centessa Pharmaceuticals plc has received clearance of its IND application from the FDA to initiate a first-in-human phase I/IIa trial of LB-101 for the treatment of solid tumors.
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Infection

Tecnimede-Sociedade Tecnico-Medicinal discovers new compounds for tuberculosis

Jan. 27, 2023
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Tecnimede-Sociedade Tecnico-Medicinal SA has described heterocyclic compounds reported to be useful for the treatment of tuberculosis.
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Gastrointestinal

Researchers present new NLRP3 inflammasome inhibitors

Jan. 27, 2023
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Astrazeneca AB and Mitsubishi Tanabe Pharma Corp. have divulged NLRP3 inflammasome inhibitors reported to be useful for the treatment of liver, autoimmune and inflammatory bowel disease, inflammation, respiratory, cardiovascular and renal disorders.
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Cancer

Janssen Pharmaceutica describes new NLRP3 inflammasome inhibitors

Jan. 27, 2023
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Janssen Pharmaceutica NV has identified 5-oxo-pyrido[2,3-d]pyridazin-6(5h)-yl acetamides acting as NLRP3 inflammasome inhibitors reported to be useful for the treatment of cancer, viral hepatitis, diabetes, immunological, inflammatory, neurological, cardiovascular and metabolic disorders.
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Cancer

Medshine Discovery divulges new MAPK3 and MAPK1 inhibitors for cancer

Jan. 27, 2023
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Medshine Discovery Inc. has synthesized dimethyl-substituted thiazololactam compounds acting as mitogen-activated protein kinase 3 (MAPK3; ERK1) and/or (MAPK1; ERK2) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Researchers patent new androgen receptor antagonists for prostate cancer

Jan. 27, 2023
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Shanghai University of Traditional Chinese Medicine and Vestlandets Innovasjonsselskap AS (VIS) have disclosed bufalin derivatives acting as androgen receptor antagonists reported to be useful for the treatment of prostate cancer.
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Drug Design, Drug Delivery & Technologies

Genkore establishes collaboration on in vivo gene editing therapies

Jan. 27, 2023
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Genkore Inc. has entered into a strategic research collaboration with a U.S.-based biopharma company for the development of in vivo gene editing therapies.
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