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BioWorld - Monday, March 27, 2023
Breaking News: A special invitation for new customers – 40% discount on any BioWorld subscriptionBreaking News: Pharming’s PI3K-delta inhibitor, Joenja, wins first FDA nod in APDSBreaking News: A special invitation for new customers – 40% discount on any BioWorld subscriptionBreaking News: A special invitation for new customers – 40% discount on any BioWorld subscription
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Cancer cells
Cancer

Wigen Biomedicine Technology divulges Wee1 inhibitors for cancer

March 27, 2023
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Wigen Biomedicine Technology (Shanghai) Co. Ltd. has described 5-fluoro-7h-pyrrolo[2,3-d] pyrimidine compounds as Wee1-like protein kinase (Wee1) inhibitors potentially useful for the treatment of cancer.
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Cancer

French and Polish investigators develop salinomycin derivatives for cancer

March 27, 2023
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Researchers from Centre National de la Recherche Scientifique, Inserm, Institut Curie and Uniwersytet im Adama Mickiewicza have prepared nitrogen-containing salinomycin derivatives reported to be useful for the treatment of cancer.
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Cancer

CCR2B antagonists reported in Artica Therapeutics patent

March 27, 2023
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Research at Artica Therapeutics BV has led to the development of C-C chemokine receptor type 2 (CCR2B) antagonists reported to be useful for the treatment of cancer.
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Cancer

Shanghai Haihe Biopharma Co. Ltd. patent describes SOS1 inhibitors

March 27, 2023
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Son of sevenless homolog 1 (SOS1) inhibitors have been reported in a Shanghai Haihe Biopharma...
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Neurology/Psychiatric

Insusense patents sortilin antagonists

March 27, 2023
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A recent Insusense ApS patent describes 2-amino-5,5-dimethylhexanoic acid derivatives as sortilin...
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Cancer

Preclinical data presented for WNK inhibitor WNK-463

March 27, 2023
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Researchers from LMU Munich discussed the role of WNK serine/threonine kinases 1 to 4 silencing in human prostate stromal WPMY-1 cells.
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Dividing breast cancer cell.
Cancer

Breast cancer progression promoted by circDNAJC11 interaction with TAF15, study finds

March 27, 2023
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Breast cancer (BC) is a prevalent form of cancer among women globally. Recent studies suggest that circular RNA (circRNA) plays a significant role in BC progression, but the biological functions and underlying mechanisms remain unexplored. According to a recent study published in the Journal of Translational Medicine, the interaction between circDNAJC11 and TATA-box-binding protein-associated factor 15 (TAF15) promotes BC progression through the upregulation of MAPK6 expression and activation of the MAPK signaling pathway.
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Respiratory

TREM-1 acts as a necroptotic stimulus of alveolar macrophages in acute lung injury

March 27, 2023
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New research has shed light on a molecular mechanism that fuels inflammation in acute lung injury (ALI), a severe and often fatal condition. Macrophage necroptosis, a form of cell death, is a necessary process contributing to intrapulmonary inflammation during ALI. However, the molecular mechanism that initiates macrophage necroptosis has remained unclear until now.
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Illustration of pill being analyzed
Substance Use & Poisoning

Toxicity data reported for VK-4-116 following once-daily oral dosing in rats and dogs

March 27, 2023
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Researchers from the National Institutes of Health recently presented preclinical data for the dopamine D3 receptor antagonist VK-4-116, which has potential for the treatment of opioid use disorder (OUD).
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Cancer

Microprotein TINCR identified as a novel tumor suppressor in squamous cell carcinoma

March 27, 2023
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Scientists have discovered a new tumor suppressor that could play a crucial role in the development...
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