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BioWorld - Tuesday, May 24, 2022
Home » Authors » Cormac Sheridan

Cormac Sheridan

Articles

ARTICLES

Concert builds toward grand finale as CTP-534 hits its mark in pivotal alopecia trial

May 23, 2022
By Cormac Sheridan
No Comments
Concert Pharmaceuticals Inc. is on track for an NDA filing for CTP-543 in alopecia areata during the first half of 2023, following a positive read-out from the first of two phase III trials of the oral Janus kinase 1/2 inhibitor. The molecule hit the primary endpoint of the placebo-controlled Thrive-AA1 study, which was defined as the percentage of patients achieving a SALT (Severity of Alopecia Assessment Tool) score of 20 or less after 24 weeks of therapy.
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Almirall taps into Evotec discovery platform in dermatology alliance

May 19, 2022
By Cormac Sheridan
No Comments
Evotec AG and Almirall SA have entered a multitarget drug discovery alliance focused on severe skin disease, from which Evotec could earn up to €230 million (US$243.5 million) in per-program milestones. It is also receiving an undisclosed up-front payment, research funding and, should any products reach the market, it would also bank sales royalties in the high-single-digit percentage range.
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DNA illustration

Swanbio closes $56M series B round to move AMN gene therapy to the clinic

May 18, 2022
By Cormac Sheridan
No Comments
Swanbio Therapeutics Inc. closed a $56 million series B round to take its lead gene therapy program, SBT-101, into clinical development later this year. The candidate, comprised of an adeno-associated virus type 9 vector encoding the ABCD1 peroxisomal ATP-binding cassette transporter, is in development for adrenomyeloneuropathy (AMN), an inherited disease that affects the central nervous system.
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Induced pluripotent stem cells

Evotec, Sernova team up to develop functional cure for type 1 diabetes

May 17, 2022
By Cormac Sheridan
No Comments
Evotec AG and Sernova Corp. are joining forces in a bid to develop a functional cure for type 1 diabetes. The companies plan to file an IND early in 2024 for a combined cell therapy and medical device product comprising Evotec’s human beta cells, derived from the company’s induced pluripotent stem cell platform, and Sernova’s Cell Pouch delivery system, which provides transplanted cells with a vascularized, physiologically appropriate environment that enables them to secrete insulin and other hormones involved in regulating blood glucose levels.
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Astrazeneca widens hunt for epigenetic drugs in second Proteros deal

May 16, 2022
By Cormac Sheridan
No Comments
Astrazeneca plc has signed up for more of the heavy-duty structure-based drug discovery services Proteros Biostructures GmbH specializes in, inking an extension to their existing collaboration agreement.
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Eye wireframe illustration
Newco news

Vigeneron carves out space in evolving AAV gene therapy landscape

May 13, 2022
By Cormac Sheridan
No Comments
Although gene therapy is now “a clinical reality,” it still remains an early stage therapeutic modality. That’s the view of Caroline Man Xu, CEO and co-founder of Vigeneron GmbH, a German gene therapy company that has maintained a low profile while steadily staking out a promising position in gene therapies for inherited retinal disease.
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Mooted reverse merger with Medsenic a lifeline for Bone Therapeutics

May 12, 2022
By Cormac Sheridan
No Comments
Bone Therapeutics SA has entered an exclusive three-month discussion period with Medsenic SAS, which could culminate in a reverse merger. The potential transaction represents a lifeline for the troubled Belgian cell therapy developer, which is running out of cash and which has been more or less abandoned by its shareholders.
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Oxurion shares fall 40% on phase II miss in DME

May 9, 2022
By Cormac Sheridan
No Comments
Shares in Oxurion NV dropped 40.3% percent May 9 on news that one of its two clinical-stage assets, THR-687, failed to demonstrate efficacy in a phase II trial in diabetic macular edema (DME). The candidate, a small-molecule pan integrin receptor antagonist, failed to demonstrate efficacy in Part A of the trial, called Integral, in which treatment-naïve patients received one of two doses of THR-687.
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Flower with dollar sign

Dianthus blossoms with $100M series A round to target complement system

May 3, 2022
By Cormac Sheridan
No Comments
Dianthus Therapeutics Inc. has, appropriately, flowered in springtime. The Waltham, Mass.-based company emerged from stealth with $100 million in series A funding and lofty ambitions to rewrite the rules of targeting the complement system with a pipeline of antibodies that bring new levels of selectivity to an area of innate immunity that has proved difficult to target.
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Swiss currency

Swiss biotech raises $3.4B investment in 2021

May 3, 2022
By Cormac Sheridan
No Comments
Switzerland’s biotechnology sector maintained its strong investment performance in 2021. The final tally for the year came to CHF3.33 billion (US$3.4 billion), which is almost equivalent to its record-breaking total of CHF3.4 billion for 2020.
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