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BioWorld - Wednesday, May 31, 2023
Home » Authors » Cormac Sheridan

Cormac Sheridan

Articles

ARTICLES

Despite setbacks momentum in ALS builds

May 26, 2023
By Cormac Sheridan
No Comments
Lack of efficacy brought the development of two investigational agents for amyotrophic lateral sclerosis (ASL) to a halt over the past week. On May 23, Wave Life Sciences Inc. disclosed that its stereopure antisense oligonucleotide WVE-004 failed to demonstrate clinical benefit after 24 weeks of treatment on a phase Ib/IIa trial in familial ALS patients or frontotemporal dementia patients. And on May 25, Apellis Pharmaceuticals Inc. and its partner, Swedish Orphan Biovitrum International AB, said that pegcetacoplan failed to meet its primary endpoint of a one-year phase II trial in patients with sporadic disease.
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Boundless Bio closes $100M series C round to target extrachromosomal-DNA-driven cancers

May 16, 2023
By Cormac Sheridan
No Comments
Boundless Bio Inc. raised $100 million in a series C round to continue its highly distinctive approach to cancer therapy, which is based on disrupting the functioning of highly amplified oncogenic extrachromosomal DNA fragments.
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Cross section of brain
Newco news

Nido Biosciences raises $109M to drug novel targets in neurological disease

May 15, 2023
By Cormac Sheridan
No Comments
Nido Biosciences Inc. emerged from stealth by unveiling $109 million in series A and B equity funding and a clinical-stage program in spinal and bulbar muscular atrophy.
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Diogenx closes $30M series A round to boost beta-cell replication in diabetes

May 10, 2023
By Cormac Sheridan
No Comments
Diogenx SAS raised €27.5 million (US$30.4 million) in a series A round to move a novel therapy for type 1 diabetes into clinical development. The Marseille, France-based company is building on the research of co-founder Patrick Collombat, an expert in beta-cell regeneration, who is based at the Insitute of Biology Valrose and the University Côte d’Azur, in Nice. Its lead drug candidate comprises a recombinant R-spondin protein, which acts on the Wnt/beta-catenin signal pathway to boost replication of endogenous functioning beta-cells.
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Sobi entering myelofibrosis fray with $1.7B offer for CTI Biopharma

May 10, 2023
By Cormac Sheridan
No Comments
Swedish Orphan Biovitrum (Sobi) AB is offering a hefty 95% premium to shareholders in CTI Biopharma Corp., as it tables a $9.10-per-share cash offer for the company, which implies a total equity valuation of $1.7 billion. Shares in Seattle-based CTI (NASDAQ:CTIC) had closed May 9 at $4.82 but surged 85% to close at $8.93 during trading May 10. The premium calculation is based on CTI’s 30-day volume-weighted average trading price of $4.67 prior to the deal announcement.
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Day of reckoning looms for Morphosys

May 4, 2023
By Cormac Sheridan
No Comments
By the end of this year, it will become apparent whether Morphosys AG has executed one of the biotechnology industry’s boldest pivots in recent years or has instead blown $1.7 billion of investor cash on a dud. The day of reckoning is coming a little sooner than expected for the Planegg, Germany-based firm, as it has completed recruitment in a phase III trial of pelabresib in first-line myelofibrosis ahead of schedule. Top-line data from the study are now expected before year-end, instead of early 2024.
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Felix Wong, co-founder and CEO, Integrated-Biosciences
Newco news

Integrated Biosciences trains neural networks to identify novel senolytic drugs

May 4, 2023
By Cormac Sheridan
No Comments
Integrated Biosciences Inc., an early-stage startup that is combining synthetic biology and machine learning in the hunt for drugs that tackle cell senescence, has demonstrated its capabilities in a newly published study in Nature Aging on May 4, 2023, which employed artificial intelligence to identify three novel compounds that are highly selective for Bcl-2 and that exhibit favorable medicinal chemistry profiles.
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Drug Design, Drug Delivery & Technologies

Integrated Biosciences trains neural networks to identify novel senolytic drugs

May 4, 2023
By Cormac Sheridan
No Comments
Integrated Biosciences Inc., an early-stage startup that is combining synthetic biology and machine learning in the hunt for drugs that tackle cell senescence, has demonstrated its capabilities in a newly published study in Nature Aging on May 4, 2023, which employed artificial intelligence (AI) to identify three novel compounds that are highly selective for Bcl-2 and that exhibit favorable medicinal chemistry profiles.
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Orbital Therapeutics lands $270M series A round to join the next cycle of RNA innovation

April 26, 2023
By Cormac Sheridan
No Comments
Orbital Therapeutics Inc. raised $270 million in a series A round to fund a big push into the next generation of mRNA-based therapies. The Cambridge, Mass.-based firm is building out a comprehensive RNA platform from which it will launch programs in oncology, autoimmune disease and indications involving protein replacement approaches.
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Hands illustrating pain and inflammation
Newco news

Ventoux Biosciences takes aim at Dupuytren’s disease

April 25, 2023
By Cormac Sheridan
No Comments
Dupuytren’s disease is often referred to as “the most common crippling hand condition that people have never heard of,” but Kurt Harrington is on a mission to change that. A seasoned biotech and pharma consultant, Harrington has had the condition himself for over a decade and, acutely aware of the lack of available treatment options, has founded Ventoux Biosciences Inc. to bring additional therapies forward.
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View All Articles by Cormac Sheridan

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