Guilford Pharmaceuticals Inc. on Thursday said adjustments in its voluntarily suspended Phase III study with Aquavan may extend only "modestly" the time to filing a new drug application, but Wall Street proved unforgiving, as investors took away more than 33 percent of the stock's value. (BioWorld Today)

Something of a rumble is shaping up in opioid-induced bowel dysfunction, as a pair of companies race to get a drug on the market for the condition. (BioWorld Financial Watch)

It's one down, one to go for Amylin Pharmaceuticals Inc., which won a hard-fought approval by the FDA of injectable Symlin (pramlintide acetate) for patients with Type I or Type II diabetes, whose insulin is not giving them glucose control. (BioWorld Today)

Metabasis Therapeutics Inc.'s overseas partner Sankyo Co. Ltd. pulled the plug on a pair of studies with CS-917, the glucose pathway inhibitor for diabetes, after two serious averse events apparently involving potentially fatal lactic acidosis. (BioWorld Today)