Methicillin-resistant S. aureus (MRSA) causes difficult-to-treat infections due to its inherent resistance. Thus finding new strategies to overcome MRSA resistance is critical. Researchers from China Agricultural University reported on the discovery and optimization of a novel series of pleuromutilin derivatives containing benzoxazole-2-thiol.
The development of novel antimicrobial agents is crucial to combat the emergence of multidrug-resistant bacteria, which cause millions of deaths and high economic losses. Researchers from Shaanxi University of Science & Technology and colleagues reported on the design and optimization of new pleuromutilin derivatives intended for use as antibacterial drugs against multidrug-resistant gram-negative bacteria.
The U.S. FDA has granted de novo approval for Bonesupport AB’s Cerament G, an antibiotic-eluting bone graft designed to osteomyelitis. The company plans to launch in the U.S. in late September or early October.
Aicuris Anti-Infective Cures AG has expanded an antibacterial collaboration with Lysando AG to focus on a topical treatment for diabetic foot infections, based around technology that attacks bacteria using specially-designed molecules based on phage proteins.
In emergency situations, broad-spectrum antibiotics have their place. But their indiscriminate use has led to a resistance crisis that already kills tens of thousands of people annually in the U.S. alone.