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BioWorld Science

Aug. 16, 1996

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Ono claims PGE2 agonists and antagonists

Pain found to trigger unique pattern of brain responses

VML-251 phase IIa results reported

Psoriasin role in psoriasis pathology under scrutiny

Phytopharm files for U.K. marketing approval of Zemaphyte

Microsponge retinol system to be codeveloped by APS and Avon

Gist-Brocades describes clavulanic acid diamine salts

U.S. patent issued for (R)-lomefloxacin

Prodesfarma to distribute Amphotec in select European markets

Preclinical results presented for RCK-11

FDA approves generic clotrimazole

Lidak initiates further trials of Lidakol in oral herpes

Hybridon prepares for GEM-132 clinical testing

HHV-8 implicated in KS development

Bayer discloses HIV protease inhibitors

Higher doses of GEM-91 administered in phase I/II trial

Preclinical development of GEM-92 underway at Hybridon

HIV integrase inhibitor effective, non-toxic in vitro

HIV vaccine research at NIAID

WHO studies role of progesterone in HIV transmission

P-selectin inhibitors reported by BMS

Nisshin Flour Milling describes agents for septic shock

Kureha discloses MMP-inhibitory esculetin derivatives

Antiarthritic MMP inhibitor described by Chugai

Supplementary approval granted for Tripedia

FDA approves expanded use of Acel-Imune

CSL discloses HPV vaccine components

Oxygermylpropionic acid polymer reported by Sanwa Kagaku

Acellular antiBortedella vaccine claimed by Institut Pasteur

NCI supports clinical testing of MGI-114

NCI begins pediatric study of carboplatin/RMP-7 combination

SS Pharm. discloses antitumor platinum complexes

SuperGen acquires marketing rights for Barr generic drugs

Sanofi Winthrop discloses topoisomerase II inhibitors

Guilford to develop anticancer drugs in biodegradable polymers

Letrozole approved for marketing in France

U.S. patent will issue covering GLIOMAB-H

MAM-102: antineoplastic protein tyrosine kinase inhibitor

ISIS-3521/CGP-64128A efficacy shown in preclinical models

GEM-230 in preclinical testing at Hybridon

Mitsui Toatsu claims potential antitumor agents

Kyorin, Sagami report antineoplastic acrylamides

Pola claims antisense oligonucleotides for cancer

Advanced Therapies, Genetic Therapy collaborate on gene therapy

Somatix issued patent on glioma gene therapy

Somatix in-licenses Salk gene transfer technology

StressGen licenses cancer gene therapy technology from MRC

Cannabinoid receptor ligands for glaucoma reported by Merck Frosst

Takeda claims benzothiepin derivatives to treat bone disease

RPR reports squalene synthase inhibitors

Hypolipidemic agents described by Bayer

GW-5823: CCK-A agonist for treatment of obesity

ImmuCell, Agri-Mark establish lactoferrin JV

Nicoderm CQ approved for OTC use

ImmuLogic receives SBIR grant for cocaine vaccine research

Xytronyx periodontal tissue monitor nears marketing

Bard to comarket ProstaScint with Cytogen

BCT launched in U.S.

Home Access HIV testing system cleared for marketing in U.S.

Conceptus begins clinical testing of STARRT falloposcopy system

Histamine H3 agonist increases slow-wave sleep in rats

5-HT2 receptor ligands reported by Allelix

LY-23728, 5-HT2B antagonist reported by Lilly

first clinical study results reported for Ro-48-6791

Roche profiles pharmacokinetics, pharmacodynamics of new benzodiazepine

BTS-73947: new D1/D5 antagonist from Knoll

Allelix describes D4 antagonists for schizophrenia

Meiji Seika claims bicyclic thiazoles for CNS disorders

Lamotrigine, valproate tested in mood disorders

Pfizer investigates enantiomeric profiles of citalopram, fluoxetine

Neurocrine Biosciences receives SBIR grant for combinatorial chemistry technology

Aptamer-based PCR system to be codeveloped by NeXstar and Roche

Hereditary hemochromatosis gene discovered

Chantal relocates to Florida

Apotex acquires ACIC Canada, Inc.

Genetic insights into MS reported

NBI-5788 to enter clinical testing for M.S.

Myotrophin expanded access program initiated

Sandoz announces Exelon pivotal study results

Marinol potential in Alzheimer's disease patients reported at congress

GABA-A receptor ligands disclosed by Synthelabo

Taisho describes NGF production promotors

SmithKline Beecham takes over Bradycor development

Calpain inhibitor PD-150606 shows neuroprotective effects

Ipratropium bromide relieves rhinorrhea, sneezing in cold patients

Roche Bioscience, LeukoSite to investigate drugs for allergy and asthma

PDE IV inhibitors claimed by Euroceltique

IL-8 role in emphysema and asthma suggested

SKB discloses drugs for IL-8-mediated disorders

LMA-Flexible introduced by Gensia

Pseudostat enters phase II in CF patients

American Cyanamid claims vasopressin antagonists

Antihypertensive quinazoline derivatives described by Nippon Chemiphar

Kanebo reports Na+/H+ exchange inhibitors

Zynaxis to develop Zyn-Linker form of heparin under SBIR grant

Cardiac tropinin provides accurate detection of MI

PLC Systems granted patent integral to Heart Laser technology

Pilot study results reported for CytoTAb

Favorable safety review for Neuprex

Corvas discloses thrombin inhibitors

Anticoagulant hirudin analogue NF-22 designated developmental candidate

SKB reports fibrinogen antagonists

Fibrinogen antagonists claimed by Toyama

Sanofi describes fibrinogen antagonists

Sepracor to develop (S)-doxazosin for BPH; U.S. patent granted

U.S. patent granted for (S)-oxybutynin

Glaxo Wellcome fights Novopharm attempt to market generic ranitidine

Novopharm states intention to market generic ranitidine

U.S. patent reinforces OraVax's UreAB development position

BXT-51072 in phase I clinical trials

Zadaxin filing in Taiwan appears imminent

Hepagene efficacy confirmed in phase III

HemoCleanse, VivoRx to collaborate on bioartificial liver device

Beta3 agonists reported by Dainippon

TheraTech studies oral mucosal delivery system for GLP-1

Antidiabetic efficacy of ABB demonstrated in rats

Antidiabetic potential of CDP-571 assessed, rejected in human trials

BASF to manufacture Ares-Serono's hGH

Andropatch marketed in U.K.

Zonagen initiates pivotal trials of Vasomax

Conceptus reports clinical advances with S/TOP system

Coagulation factor X inhibitors described by Yamanouchi

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