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BioWorld Science

May 10, 1996

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Mimetix, NanoSystems to collaborate on novel naproxen formulation

MK-462 deserves further study in migraine indication

Naropin introduced in first markets

Avita effective for acne, less irritating

Fuji Photo Film discloses dermatologic agents

SKB's intranasal mupirocin now available in U.S.

Bayer claimes quinolones and naphthyridines

Supplemental NDA filing for Abelcet

Nichinichi reports novel approach to antifungal Rx

Mentax clinical results in athlete's foot presented at conference

Sporanox-Pulse now available in U.K.

Vical/Merck DNA influenza vaccine moves ahead to clinical testing

Reticulose begins clinical testing for HPV indication

Academic investigators report potential anti-HIV agents

U-31355: potent HIV-1 RTase inhibitor

DuPont Merck discloses HIV protease inhibitors

Ribozyme treatment of HIV-1-infected patients

Saquinavir combinations under clinical evaluation

DaunoXome launched in U.S. for HIV-related KS

ALX40-4C blocks HIV infection

Hoechst claims treatment for chronic polyarthritis

New immunosuppressants from Tsumura

Axis Genetics scales up CVP production in anticipation of clinical trials

Jenner Technologies in-licenses MTP-PE from Ciba

Oncolysin B effective in tumor models in mice; phase II trials underway

Melacine NDA filing in sight

Hybridon will file IND for antisense PKA down-regulator

SunPharm to test DEHOP in cancer patients

Compassion use trial of PN 27.1 in prostate cancer patients underway

Receptagen discovers vitamin B12 uptake inhibitor

New cytokine purified by Japanese investigators

Rb gene therapy for bladder cancer described at urology meeting

GEM-132 IND filing imminent

AI-300 effective in preliminary clinical study

Bone-regulatory activity of oncostatin M reported

Corydalin: ACAT inhibitor from natural source

Yakult claims ACAT inhibitor from natural source

Hoechst claims bile acid sequestrants

Nehydrin improves cognitive recovery during alcohol withdrawal

Campral EC now available in U.K.

Merck Frosst files IND for thrombus-imaging agent

PSA II assay may distinguish prostate cancer from BPH at early stage

HIVAG-1 Monoclonal cleared by FDA

SP-16 for male and female fertility indications

Composition-of-matter patent issued for CC49

Taisho discloses new series of sigma-receptor ligands

Santen reports sigma receptor ligands as potential psychopharmacologic drugs

5-HT reuptake inhibitors reported by HMR

RiboGene and Abbott collaborate on antifungal drugs

BioChem, Oncogene to investigate treatments for HCV, HIV

Hyal to study agents for macular degeneration

Gryphon, SKB to study mirror image proteins

CR1 technology licensed to CytoTherapeutics

Sterizone System to be evaluated in Cornell study

CEPRATE SC approvable for autologous BMT

Optex receives NIH grant to develop Catarex

Dyax phage display technology receives patent protection

Progene Partners dissolved upon completion of goals

Taro's antiepileptic drug in development in USA

Tocris Cookson will distribute SYM-2206 for research purposes

New pediatric approval for Zofran in U.K.

Bayer reports K+ channel modulators for CNS disorders

GR-175737: H3 antagonist for cognition disorders

Galanthamine effective in delaying AD progression

Daicel reports neuronal cell protectant

R-844: Novel steroid for asthma

E. Merck continues to investigate angiotensin II blockers

Antihypertensive activity reported for FR-149581

RS-66252 selective for AT1 receptors in vitro

Mavik aproved for marketing in U.S.

P&U reports most potent K(ATP)-channel blocker yet discovered

Ciba-Geigy reveals renin inhibitors

Endothelin antagonists reported by Bristol-Myers Squibb

LU-135252 improves pulmonary hypertension in rats

PD-161721: A new tool for the study of ET receptors

New antihypertensive/diuretic isolated from natural source

Napp introduces novel diltiazem formulation in U.K.

5-HT2 antagonists claimed by Toa Eiyo

Cardioprotective activity of LU-51198 demonstrated in animal model

Zynaxis to develop Zyn-Linker form of paclitaxel for restenosis Rx

Cylexin phase II results announced

Na+/H+-exchange inhibitors revealed by E. Merck

More Na+/H+-exchange inhibitors from Hoechst

Structure disclosed for KCB-328

Structure revealed for UK-1745

Advisory committee refuses to recommend Coreg approval for CHF

Nippon Steel discloses anticoagulant, antithrombotic peptide

Taisho research into fibrinogen antagonists

Platelet antiaggregatory activity seen with Asahi's L-103

Terazosin and finasteride reduce PSA serum levels: Implications for diagnostic testing

Novel non-pharmaceutical approach to BPH presented

Terazosin and finasteride go head-to-head in VA study

Terflavoxate development halted

L-Arginine potential for treating interstitial cystitis

TBC-11241 protects against dye-induced hemodynamic changes in rats

James Black Foundation describes CCK-B/gastrin receptor antagonist

Tobishi reports outstanding selectivity of it's CCK-A antagonist

Potential pancreatitis treatments reported by Snow Brand

Sandoz synthesizes new antidiabetic agents

EU approval granted for Humalog

AI-401 progresses to phase II

Sildenafil demonstrates efficacy in erectile dysfunction Rx

Muse safety and efficacy reported at urology meeting

Estring approved for marketing in U.S.

Estraderm MX launched in U.K.

LY-329186 + aspirin effective in canine thrombosis model

Cel-Sci announces promising results with TB vaccine

CD45RB for organ transplant rejection

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