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BioWorld Science

March 31, 1998

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Role of protease inhibitors in chemotherapy explored at AACR meeting

Green tea extract shows potent chemopreventive activity in vitro

Pharmacological profile of new PDE V inhibitor from Eisai

Toyama researchers characterize antiplatelet/antithrombotic effects of T-250

Phase I study results reported for TP10 in AMI

KW-5617: a calmodulin inhibitor with antidiarrheal activity

FDA clears pravastatin for stroke prevention

ACE inhibitors outshine Ca2+ channel blockers for preventing cardiovascular events in diabetics

Antiarrhythmic Na+/H+ exchange inhibitors prepared by Hoechst

Abbott describes LMW mimetics of TGF-beta

Novel camptothecin derivative from Chong Kun Dang presented at AACR

Novartis presents new antitumor agents at AACR

Quinoline derivative from Green Cross/Asahi Glass shows promising antihypertensive efficacy

New York researchers discover M-47, a DNA-damaging agent with a complex mechanism

DuPont Merck searches for orally active cyclic urea HIV protease inhibitors

Taisho's H2 antagonist displays potent antiulcer activity in preclinical models

New peripheral vasodilator from Otsuka profiled at recent meeting

Sumitomo presents new NHE inhibitor with neuroprotective effects

Japanese scientists develop potent, orally active antihypertensive agent

Moguisteine, a potential agent for treating allergic cough

Melatonin may be involved in the hypnotic activity of zaleplon

New antiplatelet and antithrombotic agent characterized by Taisho

First regulatory filing made for Biota's flu drug

P&U develops antidiabetic amino- and diaminoguanidines

New taxanes reverse MDR in breast cancer cells

Potent and selective PDE III inhibitor in development at Otsuka

Kissei presents promising new agent for premature labor

Endothelin antagonist from Teikoku Hormone inhibits intimal hyperplasia

Viramune triple RT therapy provides sustained reduction in HIV-1 RNA to undetectable levels

Topical glucocorticoid from Nissin Food shows more local activity, less systemic side effects

Novo Nordisk concludes Japanese agreement for levormeloxifene