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BioWorld Science

April 1, 1998

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Anticoagulants in development at DuPont Merck

Vitamin E supplementation may prevent prostate cancer in male smokers

Case study of a patient with severe dyshidrotic eczema treated with mycophenolate mofetil

Company Profile: Direct Therapeutics

Novel antiosteoporotic compound discovered by AHP

A-74283: a 5-HT1A agonist with potent hypotensive effects in SHR

Preliminary results of TIMI 15A trial reported at ACC

New developments in signal transduction inhibition discussed at AACR meeting

Zeneca in-licenses novel chiral anesthetic agent

Pharmacokinetic study of biapenem indicates safety in various patient groups

Bayer investigates CETP inhibitors as hypolipidemic/antiatherosclerotic agents

Antibacterial quinolone carboxylic acids prepared at Bayer

NOS inhibitors claimed by Schering AG for CNS disorders

Patient enrollment in Provir phase III trial begins

Novel therapies for type II diabetes disclosed by HMR

Synthelabo claims compounds with selective affinity for certain GABA-A receptors

OPC-24439, a new sigma-receptor ligand, suppresses hippocampal neuronal activity

New vasopressin antagonist from JT with aquaretic effects in animals

Ajinomoto presents pharmacological results with novel antiarrhythmic agent

Chronic treatment with pranidipine and nicardipine compared in SHR

MCI-225: neurochemical profile of a novel antidepressant

Effects of MKC-242 on cholinergic neurons examined using in vivo microdialysis

Zenarestat potentially useful for both NIDDM- and IDDM-associated neuropathy

FDA approves DDAVP tablets for nocturnal enuresis in children

Toyama's T-593 associated with improved quality of ulcer healing compared to other H2 blockers

New diaminoguanidine for diabetes presented by Pharmacia & Upjohn

CollaGenex submits Periostat NDA amendment to FDA

Results from experimental studies suggest potential of MCC-135 in AMI, heart failure

Novel 5-HT4 agonist in development at Yoshitomi for GI motility disorders