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BioWorld Science

March 13, 2000

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Patent covers charged tamoxifen derivatives for cancer therapy

Kinetek acquires Tyrogene, PTP platforms

BioQuest and BioKeys sign letter of intent

Curatek begins pivotal trial of clonidine gel for neuropathic pain

Liposomal PGE1 to enter phase III trials in critical limb ischemia

Orphan Medical updates Xyrem development and plans for NDA submission

AVI BioPharma accelerates development of platform technologies during 1999

NHLBI stops part of ALLHAT study prematurely, advises against first-line use of alpha-blockers

Regeneron and Emisphere establish collaboration for oral delivery of Axokine

The FDA approves Pacis immunotherapy for treatment of bladder cancer

Phase III trial of Anogesic as treatment for anal fissure pain commences

Amrad gets the go-ahead to move two new drugs into clinical testing

Alizyme reports successful completion of phase I trial for IBD therapy

Malignant melanoma antisense compound enters pivotal trials

AEterna cleared to commence phase III trial of AE-941 for treatment of kidney cancer

Connetics files IND for a phase II trial to evaluate ConXn in peripheral vascular disease

New anti-HIV agents produced by Streptomyces species

Japanese labs conduct joint research on squalene epoxidase inhibitors

Distamycin used as lead at P&U to design new alkylating agents

Suntory's new antiinflammatory agents act as inhibitors of NF-kB

Shionogi prepares chymase/cytokine inhibitors with beta-lactam structure

Triazolopyridine antiplatelet agents in the pipeline at Ortho-McNeil

Enteric-coated methylnaltrexone efficiently prevents GI effects of morphine in humans

Lipitor receives approval in Japan

EMLA cream useful as local anesthetic for epidural needle insertion, orotracheal intubation

Propofol derivative with different behavioral profile: effects on neurotransmitter release

BMS-193884 safely improves hemodynamics in heart failure patients; data presented to ACC

Preclinical, clinical studies on Sch-58235 presented at ACC meeting, support further investigations

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