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BioWorld Science

May 28, 2001

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Connetics makes changes to focus on dermatology business

Suppression of cold I/R injury in liver transplantation using p38 MAP kinase inhibitor

Similar reductions in cytokine production seen in monkeys treated with A-285222 or ciclosporin

Novel TNF-alpha inhibitor prevents liver failure, promotes liver regeneration following HTx

Endovasc provides Q1 2001 update

Small-molecule inhibitor of IKK complex prevents acute cardiac allograft rejection

Clinical trial demonstrates high response rate to infliximab in psoriasis

Interneuron reports product update

ATS 2001: JNK inhibitors as next-generation compounds for asthma

Xanelim shows promise in treatment of moderate to severe psoriasis

Efficacy and safety of inhaled insulin maintained over two years in diabetic patients

Company Profile: EpiGenX

GlaxoSmithKline's HIV vaccine candidate shows promise in preclinical trials

Potentially orally active, potent steroidal androgens designed at Organon

Xyrem provides overall improvement in narcolepsy patients

Potent, selective, second-generation PDE4 inhibitor with improved safety profile

Antiischemic agents from SCRAS act on mitochondria

Investigational anticancer agent phenoxodiol enters first U.S. trial

Company Profile: CoPharma

Bisphosphonic acid derivatives and use in treatment, diagnosis of bone diseases

New osteoclast vacuolar H+-ATPase inhibitors in the AstraZeneca portfolio

NK-30424 analogues useful as antitumor and antiinflammatory agents

Squalene synthase inhibitors designed at Eisai inhibit cholesterol biosynthesis

Novel diazepanes inhibit interaction of LFA-1 with ICAMs

Cytokine-inhibitory pyrimidines under evaluation at AstraZeneca

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