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BioWorld Science

Feb. 28, 2002

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Oncogene expression linked to instability of ribonucleotide reductase R2 gene

Inhibition of stromelysin 1 holds promise in the management of abdominal aortic aneurysm

Patients with lipodystrophy successfully treated with leptin replacement

Inhale announces multiple collaborations

Kinetek validates PKB/Akt inhibitors as proapoptotic compounds

Rhodacyanine dyes synthesized with potent and selective antimalarial activity

Tipranavir plus ritonavir: pharmacokinetics in healthy volunteers reported in Seattle

Atazanavir does not adversely affect and may have beneficial effects on lipid profiles

Local delivery of L-arginine reduces in-stent neointimal hyperplasia in humans

Specific COX-2 inhibitors as a class do not appear to adversely affect cardiovascular system

Aventis Pasteur reports that HVTN 501 trial will not proceed

Troponin I suppresses growth of lung metastases in mice

Genta updates R&D progress in 2001

Indena's Sabalselect to be evaluated in benign prostatic hyperplasia trial

BVT-933 achieves proof of concept in phase IIa obesity trial

NeuroVax achieves primary endpoint in phase I/II trial in MS

NicOx summarizes R&D progress in 2001

Lactam MMP inhibitors claimed by DuPont (now BMS)

Heterocyclic carboxamides from Pharmacia inhibit human cytomegalovirus polymerase

Cell adhesion inhibitors as antiinflammatory and immunosuppressive agents

Selective chemokine CCR3 receptor antagonists described in patent by Novartis

New compounds modulate monoamine reuptake, claimed for ADHD