BioWorld Science

Aug. 27, 2002

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Antioxidants AEOL-10113 and AEOL-10150 have protective effects on isolated pancreatic islet cells

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Oncogene BRAF is mutated in a high proportion of human melanomas

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Novel GABA-A/BDZ modulators presented by Neurogen and Lilly at ACS meeting

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Synthesis and SAR of new series of CRH1 antagonists reported in Boston

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TACE inhibitors presented by Bristol-Myers Squibb at ACS

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Compounds with potent and selective caspase-3 inhibitory activity disclosed by Merck Frosst

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5-ASA-containing prodrugs for IBD presented at ACS

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Aphton files for fast track designation for G17DT in gastric cancer

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Gleevec granted priority review for first-line use in early CML

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Sepracor and MedPointe to copromote Astelin

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SGN-15 enters phase II in advanced ovarian cancer

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Transition Therapeutics begins phase I trial of interferon enhancing therapy

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Phase III Chronogesic trial placed on partial hold pending trial protocol amendments

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BioMarin completes acquisition of Glyko Biomedical

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Incara stops patient enrollment in deligoparin trial

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Dual dopamine D4 and 5-HT2A receptor antagonists described by Lundbeck

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Compounds with utility as 5-HT6 ligands claimed in patent

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Boehringer Ingelheim claims telomerase-inhibiting carboxamides

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Dr. Reddy's Research Foundation describes antibacterial compounds in patent

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Kosan Biosciences describes compounds for gastrointestinal motility disorders

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