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BioWorld Science

March 4, 2003

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PUMA identified as the gene controlling p53-mediated apoptosis in colorectal cancer cells

Pharmacia describes inhibitors of beta-catenin/TCF-4 interaction and their use

New antiprotozoal and antifungal agents presented by U.S. team

Protease inhibitors with activity against herpesvirus designed at Asahi Kasei

Two series of CRF antagonists in early development at BMS

New beta-secretase inhibitors presented by Elan and Pharmacia

Shire reports recent R&D activities

Preliminary results from CpG-7909 proof-of-principle study announced

GSK initiates clinical trials of genomics-derived drug from HGS collaboration

Biomira summarizes 2002 progress of lead product candidates

MM-093 evaluated for activity in EAE mouse model of multiple sclerosis

HANP 1000 agreement reached

InSite Vision receives patent allowance for azalides in topical ocular infection treatment

Avandia label broadened in the U.S.

Major step forward in Pfizer-Pharmacia merger

Macrocyclic hexapeptides proven to trap Holliday junctions in bacteria

First launch announced for Zavesca

CPMP recommends removal of contraindication for i.v. fibrinolytic use in diabetic patients

Chronic propagermanium may be useful in atherosclerotic vascular disease

Potential use of selegiline hydrochloride in promoting smoking cessation

Low-dose warfarin reported to prevent recurrent venous thromboembolism

New data on the safety and antitumor effects of ISIS-2503 plus gemcitabine in advanced solid tumors

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