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BioWorld Science

Feb. 20, 2004

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First highly potent nonpeptide NK1 receptor agonist reported

Antiparkinsonian effects of adenosine A2A antagonist KF-17837 in animal models

Harvard Group to acquire assets of NexTherapeutics; IND anticipated for NXT-211

Assessment of response to melatonin replacement therapy in insomnia patients

Binodenoson reported better tolerated than adenosine in SPECT imaging

Increased cardiovascular risk found in subjects with metabolic syndrome

Interactions of NNRTIs GW-8248 and prodrug GW-5634 with HIV-1 RT investigated

Bayer BP and PPL sign termination and license agreement for recAAT program

Arexis acquires BSSL project from AstraZeneca

Purely Proteins and Abcam to develop protein/antibody tools for drug discovery

Enrollment under way in ORIGIN trial

Antiviral effects of TMC-114 and ritonavir in heavily pretreated HIV subjects

Effective prevention of perinatal HIV transmission with a nevirapine/zidovudine combination

New ER modulators presented by Ortho-McNeil researchers

Aventis describes NIK inhibitors and their use in inflammatory disorders

Novel antiangiogenic alphavbeta3 integrin inhibitor reported by Sigma-Tau

New NPY Y5 receptor antagonists in early development at Schering-Plough

Novel antiproliferative CDK inhibitors prepared and tested by Indian scientists

Vertex presents new inhibitors of JNK, Src, Lck and Aurora-2 kinase

New nicotinic receptor modulators emerged from Targacept R&D

Novel CCR3 antagonists for asthma therapy claimed by Roche

FemmePharma and Emory University to identify topical microbicides against HIV

MS-325 NDA accepted for filing

CX-516 mild cognitive impairment trial fails to meet primary endpoint

FDA approves Rhophylac

New TB vaccine enters clinical testing

Mid-year BLA filing planned for Antegren in MS

Poor phase III trials for Vanlev

Enrollment under way in phase III trial of Hyphanox

Nymox files PMA for AlzheimAlert test

Fast track status for ramoplanin in C. difficile-associated diarrhea

IND filing to study Modrenal for prostate cancer

Assessment of the efficacy and safety of ciclesonide during the 4th World Asthma Meeting