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BioWorld Science

Feb. 5, 2019

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I-Mab and BCT to collaborate on arginine depletion therapy

Aprea initiates phase III study of APR-246 and azacitidine for TP53 mutant MDS

Phase II trial investigates TIMP-GLIA in subjects with celiac disease

EBV and cancer linked in more ways than one

NanoViricides advances shingles drug candidate NV-HHV-101 into IND-enabling studies

Separating latent from dead HIV genomes

TNF levels do not predict TNF blocker success

VU-6001376 demonstrates efficacy in preclinical model of Parkinson's disease

Evidence of molecular mechanism of DZ-2002 on glomerulonephritis in SLE

IgG4:IgG RNA ratio as a marker of disease activity in granulomatosis with polyangiitis

GlaxoSmithKline initiates phase I study of GSK-3844766A vaccine

First patient enrolled in phase II study of tolperisone for acute muscle spasms

SHCBP1 unveiled as therapeutic target in gastric cancer

High rate of response seen with Cytori Cell Therapy for perianal fistula in Crohn's disease

Ideaya Biosciences presents aryl hydrocarbon receptor modulators

Merck KGaA discloses new TLR7 and TLR8 antagonists

Neurotrope enters CRADA with NCI to study bryostatin-1 in leukemia and B-cell lymphoma

Guerbet identifies new compounds for liver cancer

Pivotal ICARIA-MM study of isatuximab in relapsed/refractory multiple myeloma meets primary endpoint

Phase Ib data support expansion of indication for BioXcel's BXCL-501

Theralase reports further phase Ib data on TLD-1433 in nonmuscle invasive bladder cancer

Atatuerk Ueniversitesi describes new compounds for cancer

ICMR and collaborators identify new PTP-1B inhibitors

FDA accepts IND for Spero's phase III study of SPR-994 for cUTI

SBRI funding supports Amprologix's development of epidermicin NI-01

NIH grant supports Syntrix in development of SX-682 for MDS

Reduction of BACE1 protein levels by MMP-13 inhibition shows therapeutic potential for AD in mice

Novel chimeric DNA vaccine shows prophylactic and therapeutic effect against cervical cancer in mice