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BioWorld Science

June 15, 2020

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PharmAbcine partners with Thermo Fisher to advance PMC-309

New liver metastasis biomarker and target identified

Y220X mutations impairing the thermostability of p53 can be targeted with small-molecule stabilizers

Cullinan Oncology and PDI Therapeutics collaborate to develop CLN-619

Macrophages rewire cholesterol metabolism for bacterial toxin defense

Optimized tandem CD19/CD20 CAR-engineered T cells induce durable antitumor response

First-in-human data for FP-1305

Boehringer Ingelheim reveals phase I data for BI-836880 plus BI-754091 in NSCLC

Janus kinase inhibitors patented by Jiangsu Hansoh Pharmaceutical, Shanghai Hansoh Biomedical

Yangtze River Pharmaceutical, Shanghai Haiyan Pharmaceutical Technology describe IDO-1 inhibitors

RORC antagonists presented by Jiangsu Chia Tai Tianqing Pharmaceutical, Nanjing Gear Pharma & Tech

Harvard College and Zikani Therapeutics identify new azaketolides

Roche presents DNA gyrase and/or DNA topoisomerase IV inhibitors

MDM2 inhibitor KRT-232 shows promise in phase II study in myelofibrosis patients

Initial phase I data show promise for PKCbeta inhibitor MS-553 in R/R CLL/SLL

Sinovac releases preliminary phase I/II results for CoronaVac

ILT-101 expands and activates regulatory T cells in autoimmune/inflammatory diseases

Seattle Genetics opens enrollment in phase I study of SGN-B6A for advanced solid tumors

Carsgen initiates phase I study of AB-011 in CLDN18.2-positive advanced solid tumors

New phase I study of KRAS peptide vaccine in colorectal and pancreatic cancer

Zai Lab studies anti-CD47 antibody ZL-1201 for advanced cancer in phase I

FDA approves dispersible tablet formulation of dolutegravir for infants and children with HIV

Novartis studies MAS-825 in phase II for COVID-19

FDA approves Gardasil 9 for HPV-related oropharyngeal and head and neck cancers

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