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BioWorld Science

Dec. 29, 2021

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Discovery of novel ABCB1 inhibitors that can help overcome ABCB1-mediated chemotherapy resistance

New triglyceride-mimetic structure-gated prodrug nanoplatform for precise tumor drug delivery

Red seaweed-derived iota-carrageenan shows in vitro activity against SARS-CoV-2 and VOCs

Boehringer Ingelheim, Vanderbilt University describe mutant GTPase KRAS inhibitors

New RIPK1 inhibitors discovered at Sanofi

New USP30 inhibitors identified at Mission Therapeutics

TOPADUR Pharma identifies dual PDE5A inhibitors/soluble guanylate cyclase activators

Roche identifies new antibacterials

Emendo Biotherapeutics develops CRISPR-based ex-vivo gene editing strategy for ELANE neutropenia

Blocking PAI-1 inhibits experimental PTSD development

Changing splicing lowers mutant Huntingtin

Sequential immunization strategy for HIV-1 yields off-target effects and low protection in macaques

Multiclade env-gag VLP mRNA vaccine is safe, immunogenic and protects macaques from SHIV infection

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