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Home » Newsletters » BioWorld Science

BioWorld Science

June 8, 2023

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3D illustration of the Anakinra molecular structure

Edited blood stem cells dampen disordered inflammation

Researchers have ameliorated both monogenic and complex inflammation-driven diseases through transplantation of hematopoietic stem cells with an inserted IL-1 receptor antagonist (IL-1RA) gene. The team showed that in animal models the transplanted cells worked better than monoclonal antibodies to reduce symptoms in systemic autoinflammatory diseases (SAIDs), a group of childhood-onset, lifelong diseases that vary in severity depending on the underlying mutation, but can be life-threatening. Read More

Discovery of novel PI3Kα inhibitor with promising preclinical potency and favorable PK profile

Researchers from Zhejiang University and Shanghai Institute of Materia Medica of the Chinese Academy of Sciences have reported the discovery of new phosphoinositide 3-kinase α (PI3Kα) inhibitors for the treatment of cancer. Read More
Illustration of CTLA-4 protein structure

Hybri, a novel bispecific fusion protein with immunosuppressant properties

Researchers from the Hospital Universitari Vall d’Hebron and colleagues have reported on the development of Hybri, a hybrid recombinant bispecific fusion protein with immunosuppressive activity that consists of the extracellular domain (ECD) of human PD-L2 fused via a linker to the ECD of human CTLA-4, further fused to the Fc domain of human IgG. Read More
DNA and antibodies

Gates Foundation grant supports Aegis Life’s development of DNA-encoded antibodies for infectious diseases

Aegis Life Inc. and its parent company Entos Pharmaceuticals Inc. (Entos) have entered into a grant agreement with the Bill & Melinda Gates Foundation in the area of infectious disease. Read More

Utreat inhibits tumor growth in preclinical model of human glioblastoma

Curasight A/S has announced preclinical data demonstrating the effectiveness of Utreat (uPAR-targeted radionuclide therapy) in treating glioblastoma. Read More
Drug R&D concept image.

Preclinical characterization of TLR7/8 antagonist MHV-370 reported by Novartis

Toll-like receptors TLR7 and TLR8 are endosomal receptors involved in the activation of the innate immune response. Read More

Case Western Reserve University reports development of PSMA-targeted conjugate compounds

Case Western Reserve University has patented conjugates consisting of a PSMA-targeting moiety covalently linked to a chelating agent comprising metals. Read More

Agios Pharmaceuticals divulges new BCAT2 inhibitors

An Agios Pharmaceuticals Inc. patent describes branched-chain-amino-acid aminotransferase, mitochondrial (BCAT2) inhibitors reported to be useful for the treatment of isovaleric acidemia, maple syrup urine disease, methylmalonic acidemia and propionic acidemia. Read More
Heart and lungs

ANPA-0073 and ANPA-0137, G protein-biased APJ agonists with efficacy in models of IPF and PAH

Researchers from Structure Therapeutics Inc. recently presented details on the discovery and preclinical evaluation of two new apelin receptor (APJ, APLNR) agonists – ANPA-0073 and ANPA-0137 – being developed for the treatment of pulmonary diseases. Read More

Dtx Pharma’s siRNA therapeutic Dtx-1252 awarded US orphan drug designation for CMT1A

Dtx Pharma Inc.’s Dtx-1252, an investigational small interfering RNA (siRNA) therapeutic, has been awarded U.S. orphan drug designation for the treatment of Charcot-Marie-Tooth disease type 1A (CMT1A). Read More

RORα agonists described in Seoul National University patent

Research at Seoul National University has led to the identification of thiourea compounds acting as nuclear receptor RORα (RORA) agonists reported to be useful for the treatment of inflammation and metabolic diseases. Read More
Pseudomonas aeruginosa

Antibody targeting of multiple P. aeruginosa evasion mechanisms enhances neutrophil-mediated phagocytosis and killing efficacy

Bronchiectasis is an irreversible chronic respiratory condition arising from secondary infections that presents as chronic cough with daily purulent sputum due to a permanent abnormal widening of bronchi. Read More

Alchemedicine patents new angiotensin AT1 receptor agonists

Alchemedicine Inc. has prepared and tested new angiotensin AT1 receptor (AGTR1) antagonists reported to be useful for the treatment of cancer, hypertension, glaucoma and renal disorders. Read More

Novartis describes new PCSK9 inhibitors

Novartis AG has identified diaminocyclopentylpyridine derivatives acting as proprotein convertase subtilisin/kexin-type 9 (PCSK9) inhibitors and thus reported to be useful for the treatment of hypercholesterolemia, hyperlipidemia, hypertriglyceridemia, sitosterolemia, vascular inflammation, atherosclerosis, peripheral vascular and coronary heart disease, among others. Read More
CAR T cell with implanted gene strand

Overexpression of HER2 in diffuse intrinsic pontine gliomas can be exploited for CAR T-cell therapy

Diffuse intrinsic pontine glioma (DIPG) is an almost universally fatal brain pediatric tumor and the only tumor indication where palliative radiotherapy is the current standard of care. Although chimeric antigen receptor (CAR) T-cell therapy may hold promise for treating DIPG, the elevated tumor heterogeneity and the prospect of antigen escape make the identification of additional targets crucial. Therefore, multiple targets need to be validated to facilitate a multipronged approach. Read More

Other news to note for June 8, 2023

Additional early-stage research and drug discovery news in brief, from: Karolinska Development, Tonix Pharmaceuticals, Transcode Therapeutics, Umecrine Cognition, Vycellix. Read More

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