Researchers from the Baylor College of Medicine have characterized 100 conserved Alzheimer’s disease (AD) risk orthologue genes in Drosophila and found several with unknown roles in brain structure, function and stress resilience. The implication of this finding is that new pathways of neurodegeneration have been revealed, offering new insights into the genetic complexity of AD. Read More

There is evidence that NACHT, LRR and PYD domains-containing protein 3 (NLRP3)-driven mechanisms may drive both peripheral and hypothalamic inflammation in preclinical obesity. NLRP3 inflammasome activation has been tied to the pathogenesis of obesity-related metabolic syndrome and its progression. Read More

Evotec SE has received a $5 million milestone payment from Bristol Myers Squibb Co. (BMS), following the acceptance of an IND application by the FDA in the companies’ strategic protein degradation partnership. Read More

Metagenomi Inc. has reported new dose-range-finding data from its MGX-001 hemophilia A program. MGX-001 is designed to provide curative, life-long protection from bleeding events and joint damage in adults and children with hemophilia A. Read More

A team from the University of Missouri and collaborating institutions aimed to investigate the role of ABTB2 expression in pancreatic ductal adenocarcinoma cells. To do that, they applied a comprehensive suite of functional genomics tools, including siRNA/shRNA knockdown, CRISPR-Cas9 knockout, plasmid-based overexpression and a Cre-LoxP transgenic mouse model to modulate ABTB2 expression. Read More

Editor Annette Boyle discusses the challenges med-tech companies face in bringing innovation to market and how the industry can overcome them. Read More

Researchers from Prospect Therapeutics Inc. have discovered PSTA-5204, a novel oral KRAS G12D(ON) inhibitor that exhibits potent in vitro activity, strong in vivo efficacy and high selectivity over wild-type KRAS. Read More

Shanghai Innoxtal Therapeutics Co. Ltd. has disclosed sodium channel protein type 10 subunit α (SCN10A; Nav1.8) blockers reported to be useful for the treatment of pain, arrhythmia and urinary incontinence. Read More

Researchers at Keimyung University and its medical school generated various candidate quinazolin-4-one derivatives, the most promising of which inhibited HDAC6 with an IC50 of 17 nM, 19-fold more strongly than it inhibited the off-target deacetylase HDAC1. Read More

Aurigene Oncology Ltd. recently provided details on the discovery and preclinical characterization of AUR-243, a novel CBL-B inhibitor with a distinct therapeutic profile and best-in-class potential compared to other inhibitors. AUR-243 was described as a structurally distinct, oral small molecule demonstrating excellent potency, functional activity and superior efficacy. Read More

Shanghai Leadingtac Pharmaceutical Co. Ltd. has synthesized proteolysis targeting chimera (PROTAC) compounds comprising an E3 ubiquitin ligase-binding moiety covalently linked to a GTPase KRAS (G12D mutant)-targeting moiety via a linker reported to be useful for the treatment of cancer. Read More

Beijing Infinite Intelligence Pharmaceutical Technology Co. Ltd. and Suzhou Fish-Summoning Biotechnology Co. Ltd. have identified compounds acting as Bcr-Abl (Bcr-Abl1) kinase inhibitors reported to be useful for the treatment of cancer, viral infections and neurological disorders. Read More

Quell Therapeutics Ltd. have presented data for QEL-005, a new CAR Treg-based compound that targets CD19 and contains a FOXP3 phenotype lock. Read More

Shenzhen Zhongge Biotechnology Co. Ltd. has divulged cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) inhibitors reported to be useful for the treatment of castration-resistant prostate cancer. Read More

Hangzhou Zhongmei Huadong Pharmaceutical Co. Ltd. has described E3 ubiquitin-protein ligase CBL-B (CBLB) inhibitors reported to be useful for the treatment of cancer. Read More

Evopoint Biosciences Co. Ltd. has obtained clinical trial clearance in China for XNW-34017, an oral protein degrader that targets Aurora kinase A (AURKA) while simultaneously degrading MYC. Read More

This reoccurring series features new molecular entities (NMEs) revealed for the first time in current literature, at congresses and in company communications during the quarter. Click "read more" to see a list of past reports that are available to BioWorld Science and BioWorld Premuim subscribers. Read More