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BioWorld - Friday, September 22, 2023

Cardiovascular

Home » Topics » Disease categories and therapies » Cardiovascular
  • Tavr
    Sep. 21, 2023
    By Mark McCarty

    Analysis of registry data hints minimally symptomatic patients are good candidates for TAVR

    The annual volume of implant of transcatheter aortic valve replacement (TAVR) devices has grown steadily over the years, and that volume might sustain its upward trajectory over the next few years if the results of a new analysis of more than 46,000 TAVR patients gain traction. The data for these patients with minimally symptomatic aortic stenosis (AS) predictably indicated that this group was less susceptible to bad outcomes than those with more severe symptoms, but one of the hopes is that earlier intervention into AS could ward off future cardiovascular events, a finding which might justify expanded payer coverage for TAVR in these patient populations.

  • Gold dollar sign inside gold cog
    Sep. 19, 2023
    By Randy Osborne

    Pass the (molecular) glue: Magnet school teaches new way with $50M series A

    Magnet Biomedicine Inc. emerged from stealth mode and pulled down a $50 million series A round co-led by founding investor Newpath Partners alongside Arch Venture Partners. The firm is advancing molecular glue discovery by way of rational selection and design, looking past known protein-protein interactions and what Magnet calls “tangential” degradation approaches to analyze the broader protein landscape and ultimately pair targets with rationally chosen presenters in the tissue where the disease manifests.
  • Sep. 18, 2023
    By Lee Landenberger

    Anthos’ phase II in afib hits primary endpoint and makes an early stop

    Anthos Therapeutics Inc.’s phase II study of abelacimab in treating atrial fibrillation in patients at moderate to high risk of stroke has met its primary endpoint. The data monitoring committee stopped the study early as the fully human monoclonal antibody targeting factor XI/XIa reduced bleeding when compared to a leading standard of care, direct oral anticoagulant, Xarelto (rivaroxaban, Johnson & Johnson).
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