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Home » Topics » Disease categories and therapies » Cardiovascular

Cardiovascular
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Human heart within crosshairs
Cardiovascular

Viral delivery of PNPLA2 as gene therapy for arrhythmogenic cardiomyopathy

July 8, 2025
No Comments
Arrhythmogenic cardiomyopathy is an inherited disorder that typically manifests in people younger than 40 years and for which only palliative treatments exist. For advanced cases, heart transplantation is the only therapeutic option.
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Illustration of heart analysis for DNA and drug impacts
Cardiovascular

From maps to gene therapies, who’s who in cardiovascular disease

July 8, 2025
By Mar de Miguel
No Comments
Cellular atlases and omics studies, such as genomics, transcriptomics and proteomics, have become key tools for identifying the diversity of all the elements that make up the cardiovascular system. These approaches help scientists understand how cells, genes and molecules function and interact in both healthy and diseased conditions, revealing critical points where targeted interventions could not only relieve symptoms but potentially reverse the underlying pathology at its origin.
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Farawave system

FDA greenlights Boston Sci’s Farapulse for persistent AF

July 7, 2025
By Annette Boyle
Boston Scientific Corp. gained a second U.S. FDA approval for its Farapulse pulsed field ablation catheter, expanding its use into drug-refractory, symptomatic persistent atrial fibrillation (AF) in addition to its existing approval for paroxysmal AF. The expanded indication marks the first of several regulatory approvals the company expects in the coming months.
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Ekterly pill and packaging

Missed PDUFA history as Kalvista wins FDA approval for HAE

July 7, 2025
By Lee Landenberger
No Comments
After delaying a June PDUFA date, the U.S. FDA has approved Kalvista Pharmaceuticals Inc.’s Ekterly (sebetralstat) for hereditary angioedema (HAE) in those aged 12 and older. The plasma kallikrein inhibitor now joins a market with previously approved drugs for the rare, genetic, life-threatening condition, as well as other companies with HAE drugs in development. Ekterly is the first orally-delivered on-demand treatment, as all others in the U.S. are intravenously or subcutaneously administered.
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Heart scientific overlay
Cardiovascular

Heartbeat.bio and Biotx.ai partner in heart failure

July 7, 2025
No Comments
Heartbeat.bio AG and Biotx.ai GmbH have partnered to identify and validate novel therapeutic targets in heart failure. The collaboration combines Biotx.ai’s causal mapping of the genome for target discovery with Heartbeat.bio’s human-based Cardioid drug discovery platform.
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3D heart in chest
Cardiovascular

At CRVBC 2025: Aging is circulating in your blood

July 4, 2025
By Mar de Miguel
No Comments
All kinds of substances circulate through the bloodstream. Some are beneficial, like oxygen or nutrients, and others less so, like waste products, toxins, pathogens and certain trafficking cells. Among these harmful substances are deleterious factors associated with aging, which can prematurely damage different tissues. The big question is what are those factors that mediate such effects, and what can be done to prevent them. The 11th Cardiac Regeneration and Vascular Biology Conference, held on the Island of San Servolo, Venice, from June 30 to July 2, 2025, included presentations, oral sessions and posters addressing the impact of aging on the cardiovascular system.
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FieldForce Catheter

Field reaps $35M for ventricular PFA

July 3, 2025
By Annette Boyle
Field Medical Inc. continues to reap funding from investors for its pulsed field ablation (PFA) system with a $35 million oversubscribed series B financing round. With treatment of atrial fibrillation already upended by PFA technology, Field sees ventricular tachycardia as a fertile new territory for transformation.
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Lunit

Lunit, Microsoft to codevelop cloud-based clinical AI solutions

July 3, 2025
By Marian (YoonJee) Chu
Lunit Inc. reported a new collaboration with Microsoft Corp. July 2 to jointly develop medical AI programs accessible on Microsoft’s Azure cloud platform.
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3D heart in chest

CMS deletes two specialists to NCD final for tricuspid repair devices

July 3, 2025
By Mark McCarty
The final Medicare coverage memo for transcatheter edge-to-edge repair for tricuspid valve regurgitation largely replicates the April 2025 draft, but cardiology centers will not have to bring an electrophysiologist to the patient’s care team to be permitted to practice these devices.
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Single Shot PVI

Kardium beats expectations with $250M haul

July 2, 2025
By Annette Boyle
Kardium Inc. raised C$340 million (US$250 million) in an oversubscribed financing round to support commercialization of its Globe pulsed field ablation system for atrial fibrillation. Notably, the financing included an equity investment by an unnamed leading strategic investor. Kardium could receive U.S. FDA approval as early as this quarter and plans to launch Globe in the U.S. this year.
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