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Home » Topics » Disease categories and therapies » Cardiovascular

Cardiovascular
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Cardiovascular

Rednvia patents new TNAP inhibitors for ectopic calcification

June 3, 2025
Rednvia Co. Ltd. has disclosed alkaline phosphatase tissue-nonspecific isozyme (TNAP) inhibitors reported to be useful for the treatment of ectopic calcification.
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Bivacore TAH

Bivacor pumped by artificial heart’s breakthrough designation

June 2, 2025
By Annette Boyle
The U.S. FDA’s decision to grant breakthrough device designation for Bivacor Inc.’s titanium total artificial heart (TAH) sent real hearts aflutter at the Huntington, Calif.-based company’s headquarters. While the designation supports use of the TAH as a bridge to transplant for adults with biventricular or univentricular heart failure for whom current options are insufficient or unsuitable, Bivacor hopes its device will eventually serve as a long-term heart replacement.
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Colorful illustration of the heart
Cardiovascular

Circode Biomed’s HM-2002 gains US IND clearance for ischemic heart disease

June 2, 2025
No Comments
Shanghai Circode Biomed Co. Ltd. has obtained IND clearance from the FDA for HM-2002 for ischemic heart disease. It previously received IND clearance in China in January this year.
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1-30-Abbott-Tendyne.png

Abbott Tendyne TMVR secures FDA clearance

May 30, 2025
By Shani Alexander
Abbott Laboratories recently received FDA clearance for Tendyne, its transcatheter mitral valve replacement system. The news comes on the heels of Edwards Lifesciences Corp. securing a CE mark for its Sapien M3 system and is a boon for mitral valve therapies amid ongoing frustrations about the slow adoption of TMVR technologies.
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Artery and plaque
Cardiovascular

Rona Therapeutics reports preclinical findings with RNAi therapy for cardiovascular disease

May 30, 2025
No Comments
Rona Therapeutics Co. Ltd. has reported preclinical data for its RNA interference (RNAi) therapy RN-026 targeting lipoprotein(a) (Lp[a]).
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Nex-z phase III enzyme dime-drop chops Intellia in ATTR-CM

May 29, 2025
By Randy Osborne
No Comments
Investors found in an 8-K filing by Intellia Therapeutics Inc. the news of one case of liver-enzyme elevation in the ongoing phase III Magnitude study with nexiguran ziclumeran (nex-z, NTLA-2001), and in reaction pushed shares of the firm (NASDAQ:NTLA) down to close May 29 at $7.45, a loss of $2.21, or 23%, after the stock traded as low as $6.90 during the day.
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Mitochondria

CRL blocks Barth syndrome drug; Stealth aims to try again

May 29, 2025
By Karen Carey
No Comments
Developing a therapy for an ultra-rare condition has its challenges, including finding enough patients for clinical enrollment and convincing regulatory authorities that limited data prove the candidate is safe and effective. For that reason, Stealth Biotherapeutics Inc. has faced numerous roadblocks getting its mitochondria-targeting elamipretide across the finish line for Barth syndrome, a condition that affects about 230 to 250 males worldwide, including fewer than 150 in the U.S.
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Vascular system
Cardiovascular

Efficacy and safety evaluation of the ANGPTL4 inhibitory antibody MAR-001 in nonhuman primates

May 29, 2025
No Comments
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality worldwide despite advances in managing classic risk factors and therapies lowering LDL-cholesterol. Inhibiting angiopoietin-like protein 4 (ANGPTL4), a key regulator of triglyceride metabolism, is emerging as a potential strategy to treat atherogenic dyslipidemia and lower ASCVD risk.
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Boston Scientific Acurate Prime Aortic Valve System

In TAVR setback, Boston Sci pulls plug on Acurate valves

May 28, 2025
By Holland Johnson
Boston Scientific Corp. reported the latest setback in its transcatheter aortic valve replacement (TAVR) aspirations with the news that it is officially discontinuing worldwide sales of its Acurate neo2 and Acurate Prime systems
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Shockwave IVL
EuroPCR 2025

Shockwave IVL system continues to make waves

May 28, 2025
By Shani Alexander
Shockwave Medical Inc. is confident that its intravascular lithotripsy (IVL) system can continue to dominate the market for calcium modification even as other technologies emerge, chief medical officer Nick West told BioWorld.
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