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Home » Topics » Disease categories and therapies » Cardiovascular

Cardiovascular
Cardiovascular RSS Feed RSS

1-30-Abbott-Tendyne.png

Abbott Tendyne TMVR secures FDA clearance

May 30, 2025
By Shani Alexander
Abbott Laboratories recently received FDA clearance for Tendyne, its transcatheter mitral valve replacement system. The news comes on the heels of Edwards Lifesciences Corp. securing a CE mark for its Sapien M3 system and is a boon for mitral valve therapies amid ongoing frustrations about the slow adoption of TMVR technologies.
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Artery and plaque
Cardiovascular

Rona Therapeutics reports preclinical findings with RNAi therapy for cardiovascular disease

May 30, 2025
No Comments
Rona Therapeutics Co. Ltd. has reported preclinical data for its RNA interference (RNAi) therapy RN-026 targeting lipoprotein(a) (Lp[a]).
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Nex-z phase III enzyme dime-drop chops Intellia in ATTR-CM

May 29, 2025
By Randy Osborne
No Comments
Investors found in an 8-K filing by Intellia Therapeutics Inc. the news of one case of liver-enzyme elevation in the ongoing phase III Magnitude study with nexiguran ziclumeran (nex-z, NTLA-2001), and in reaction pushed shares of the firm (NASDAQ:NTLA) down to close May 29 at $7.45, a loss of $2.21, or 23%, after the stock traded as low as $6.90 during the day.
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Mitochondria

CRL blocks Barth syndrome drug; Stealth aims to try again

May 29, 2025
By Karen Carey
No Comments
Developing a therapy for an ultra-rare condition has its challenges, including finding enough patients for clinical enrollment and convincing regulatory authorities that limited data prove the candidate is safe and effective. For that reason, Stealth Biotherapeutics Inc. has faced numerous roadblocks getting its mitochondria-targeting elamipretide across the finish line for Barth syndrome, a condition that affects about 230 to 250 males worldwide, including fewer than 150 in the U.S.
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Vascular system
Cardiovascular

Efficacy and safety evaluation of the ANGPTL4 inhibitory antibody MAR-001 in nonhuman primates

May 29, 2025
No Comments
Atherosclerotic cardiovascular disease (ASCVD) remains a leading cause of mortality worldwide despite advances in managing classic risk factors and therapies lowering LDL-cholesterol. Inhibiting angiopoietin-like protein 4 (ANGPTL4), a key regulator of triglyceride metabolism, is emerging as a potential strategy to treat atherogenic dyslipidemia and lower ASCVD risk.
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Boston Scientific Acurate Prime Aortic Valve System

In TAVR setback, Boston Sci pulls plug on Acurate valves

May 28, 2025
By Holland Johnson
Boston Scientific Corp. reported the latest setback in its transcatheter aortic valve replacement (TAVR) aspirations with the news that it is officially discontinuing worldwide sales of its Acurate neo2 and Acurate Prime systems
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Shockwave IVL
EuroPCR 2025

Shockwave IVL system continues to make waves

May 28, 2025
By Shani Alexander
Shockwave Medical Inc. is confident that its intravascular lithotripsy (IVL) system can continue to dominate the market for calcium modification even as other technologies emerge, chief medical officer Nick West told BioWorld.
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EBR Wise CRT system

EBR Systems raises $36M to sell Wise CRT therapy

May 28, 2025
By Tamra Sami
EBR Systems Inc. raised AU$55.9 million (US$36 million) to commercialize its Wise cardiac resynchronization therapy system following U.S. FDA approval in April of the wireless, endocardial pacing system to stimulate the heart’s left ventricle.
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Heart and DNA

Houston, a problem: Rocket death in Danon stalls phase II program

May 27, 2025
By Randy Osborne
No Comments
Rocket Pharmaceuticals Inc. CEO Gaurav Shah said his firm is investigating how its gene therapy for Danon disease may have created an “unexpected and paradoxical” effect that led to problems for a phase II patient who ultimately died.
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Heart scientific overlay
Cardiovascular

Frontera’s FT-017 exerts robust activity in hypertrophic cardiomyopathy

May 27, 2025
No Comments
Frontera Therapeutics Inc. has developed FT-017, an adenovirus-associated vector(AAV)-based gene therapy that carries a human MYBPC3 optimized codon, for the treatment of hypertrophic cardiomyopathy (HCM).
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