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Home » Topics » Disease categories and therapies » Cardiovascular

Cardiovascular
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Illustration of siRNA structure

Sirius bags $50M series B2 for cardiovascular siRNA pipeline

May 13, 2025
By Marian (YoonJee) Chu
No Comments
Sirius Therapeutics Inc. raised nearly $50 million in a series B2 financing round May 9 to support its pipeline of small interfering RNA (siRNA) molecules for cardiovascular disease indications. SRSD-107, a long-acting Factor XI anticoagulant for thromboembolic disorders, is its lead candidate waiting on EMA clearance to begin a phase II study in Europe. 
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Cardiovascular

Novel inhibitors of NHE1 to treat heart failure

May 13, 2025
No Comments
Inhibiting the sodium-hydrogen exchanger 1 (NHE1), which simultaneously imports Na+ and exports H+ in cardiac cells, shows therapeutic potential against heart failure.
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Illustration of siRNA structure

Sirius bags $50M series B2 for cardiovascular siRNA pipeline

May 12, 2025
By Marian (YoonJee) Chu
No Comments
Sirius Therapeutics Inc. raised nearly $50 million in a series B2 financing round May 9 to support its pipeline of small interfering RNA (siRNA) molecules for cardiovascular disease indications. SRSD-107, a long-acting Factor XI anticoagulant for thromboembolic disorders, is its lead candidate waiting on EMA clearance to begin a phase II study in Europe. 
Read More
Gold dollar sign and blue circular arrows

Haya doing well with a $65M series A for precision medicine

May 8, 2025
By Lee Landenberger
No Comments
Following last fall’s $1 billion development deal with Eli Lilly and Co., precision medicine company Haya Therapeutics SA has raised $65 million in a series A. It’s all part of increased validation from big pharmas that long noncoding RNAs, such as those being developed by Haya, have a strong future.
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Cholesterol plaque in artery

Marea looks to a phase IIb study in cardiovascular disease

May 7, 2025
By Lee Landenberger
No Comments
With positive phase IIa cardiovascular disease results in hand, Marea Therapeutics Inc. said it is ready to move on to a phase IIb study sometime in the second quarter of 2025. MAR-001, a monoclonal antibody targeting the protein coding gene ANGPTL4, produced an up to a 52.5% placebo-adjusted mean reduction in remnant cholesterol and up to a 52.7% placebo-adjusted mean reduction in triglycerides at 12 weeks.
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Heart, DNA and ECG
Cardiovascular

Nuevocor draws $45M series B for gene therapy in rare heart disease

May 7, 2025
By Nuala Moran
No Comments
Nuevocor Pte. Ltd. has closed a $45 million series B, enabling it to move lead gene therapy NVC-001 into the clinic in the treatment of an inherited form of cardiomyopathy.
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Heart with blocked arteries
Cardiovascular

A novel phosphodiesterase inhibitor against pulmonary arterial hypertension

May 7, 2025
No Comments
Chronic hypertension in pulmonary arteries leads to their remodeling, making them increasingly resistant and potentially progressing to right heart failure and premature death. Despite advances in vasodilator therapies, the prognosis of individuals with pulmonary arterial hypertension has not improved substantially in the past 20 years.
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Hilo Band and mobile app

Aktiia SA raises $42M for BP monitoring platform, rebrands to Hilo

May 6, 2025
By Shani Alexander
Aktiia SA raised $42 million in an oversubscribed series B funding round and rebranded to Hilo. The funds will be used for product innovation, expansion into new markets and to build out its blood pressure monitoring platform to support enterprise use cases.
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Heart, DNA and ECG

Nuevocor draws $45M series B for gene therapy in rare heart disease

May 6, 2025
By Nuala Moran
No Comments
Nuevocor Pte. Ltd. has closed a $45 million series B, enabling it to move lead gene therapy NVC-001 into the clinic in the treatment of an inherited form of cardiomyopathy.
Read More
Durvena
Patents

Durvena strengthens vein grafts to reduce post-surgery failures

May 5, 2025
By Simon Kerton
In what represents the first patenting to emerge in the name of Durvena Inc., co-founder and CEO John Ashley describes the development of a treatment for vein grafts that strengthens the graft and reduces the occurrence of intimal hyperplasia that commonly leads to graft failure.
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