Sanofi SA will not seek approval of amlitelimab in atopic dermatitis (AD) as previously planned, stating that the OX40-ligand monoclonal antibody “would not represent a meaningful improvement to the standard of care” for patients with moderate to severe disease. The company said the decision, which marks an about-face as Sanofi had been looking to amlitelimab as a possible successor to its Regeneron Pharmaceuticals Inc.-partnered blockbuster AD drug Dupixent (dupilumab), comes as part of an ongoing assessment of the pipeline.

Mentari Therapeutics Inc. has announced a $200 million private placement to support continued development of its pipeline of targeted biologics for migraine.

Wall Street is sifting data to figure out what Celldex Inc.’s phase II failure with KIT inhibitor barzolvolimab (barzo) in prurigo nodularis (PN) might mean for the upcoming phase III readout with the same drug in chronic spontaneous urticaria (CSU).