April 18 (EPO), April 12 (WO)
Ahlert, T. EP 1 092 439
T cell activation
Activation of antigen-specific T cells by virus- or antigen-treated dendritic cells; for stimulating immune responses.
American Cyanamid EP 1 092 775
Human CMV inhibitor screens
Finding non-essential genes in human cytomegalovirus genomes using _-glucuronidase as a marker; for inhibitor screens.
Amersham Pharmacia Biotech WO 01/25485
Methods for detecting mutations using arrayed primer extension assays.
Amgen WO 01/25445
Blood clot lysis polypeptide
Thousand Oaks, Calif.
Fibrinolytically active polypeptide, production methods; for in vivo blood clot lysis.
Angstrom Pharma WO 01/25410
uPA targeting proteins
Urokinase plasminogen activator and uPA receptor-targeting proteins; for diagnostics and therapeutics.
Artemis Pharma EP 1 092 768
Inactivation of cellular genes
Gene trap construct that conditionally inactivates cellular genes by mutation; for studying development.
Aventis Pharma EP 1 092 777
Self-cleaving RNA sequences
Self-cleaving RNA sequences from untranslated regions; for controlling protein synthesis from mRNAs.
Aventis Pharma WO 01/25278
Modified C-peptide, encoding gene sequences; for improved production of insulin and its analogs.
Aventis Pharma WO 01/25463
Recombinant adenovirus preparation
Recombinant adenoviral vector preparation; for use in functional genomics assays.
Aventis Pharma WO 01/25487
Helicase modulator screens
Electrochemiluminescent assays for detecting helicase activity; for identifying modulators.
Avi Biopharma WO 01/25422
Making lineage committed cells
Antisense oligomers directed at mRNAs expressed in stem cells; for increasing numbers of lineage committed cells.
BASF EP 1 092 771
Regulated transcriptional modulators
Tetracycline-regulated transcriptional modulators; for controlling gene expression in eukaryotic cells.
Baylor Coll. Med. WO 01/25255
Zinc finger protein
Zinc finger protein, fragments, derivatives, encoding gene sequences; for gene transcription regulation.
Biosite Diagnostics WO 01/25492
Human antibody screen
Display selection methods for screening human immunoglobulin gene libraries; for finding high affinity antibodies.
Biotransplant WO 01/25398
Inducing tolerance to myeloreduction
Hematopoietic stem cells expressing new antigens; for inducing tolerance after myeloreductive therapy.
Biovet-Uco WO 01/25279
CD29 pig protein, encoding gene sequences, modified versions; for reducing xenoreactivity in transplants.
Boehringer Ingelheim Intl. EP 1 092 780
Recombinant CELO viruses
Recombinant CELO viruses with large pieces of foreign DNA inserted; for gene therapy, vaccines, and producing protein.
Brosens, J. WO 01/25452
Cell targeting vector
Genetic constructs encoding a nitric oxide inducer that target specific cell types.
California, Univ. of WO 01/24821
Bone mineralization assay
San Francisco, Calif.
Use of human NELL-1 gene to identify modulators of bone mineralization.
California, Univ. of WO 01/25250
Her-2/neu associated genes
Differentially expressed genes associated with Her-2/neu overexpression, encoded proteins, antibodies; for cancer.
California, Univ. of WO 01/25408
Cell proliferation control
Dishelleved-associated kinases, encoding gene sequences; for Wnt/Wg signal pathway modulation to control cell growth.
Cambridge Drug Discovery WO 01/25477
Kinase modulator screens
Use of reporters to screen modulators of kinases and phosphatases.
Cambridge, Univ. of WO 01/25416
Displaying T cell epitopes
Recombinant double hybrid filamentous bacteriophage displaying cytotoxic T cell epitopes; for vaccines.
Chiron WO 01/25464
AAV vector production
Simplified methods for producing replication-defective adeno-associated virus vectors; for gene therapy.
Chiron WO 01/25489
Prostate cancer gene
Gene differentially expressed in prostate cancer; for developing diagnostics and therapeutics.
Chugai WO 01/24626
Blood coagulation modulators
Animals with cell transplants secreting human tissue factor to increase blood coagulation; for finding modulators.
Colorado State Univ. WO 01/25435
Joint disease gene therapy
Ft. Collins, Colo.
In vivo treatment of joint disease using interleukin-1 receptor antagonists encoded in an adenoviral vector.
Corixa WO 01/24820 & 25401
Mycobacterial fusion proteins
Mycobacterial antigen fusion proteins; for tuberculosis therapy and high yield heterologous protein production.
CuraGen WO 01/25429
Hepatoma-derived growth factor
New Haven, Conn.
Hepatoma-derived growth factor-like proteins, encoding gene sequences, variants, mutants; for disease treatment.
CuraGen WO 01/25436
New Haven, Conn.
Endozepine-like polypeptides, encoding gene sequences, variants, mutants; for diagnostics and therapeutics.
CuraGen WO 01/25437
Growth factor polypeptides
New Haven, Conn.
Growth factor polypeptides related to VEGF and PDGF, encoding gene sequences; for diagnostics and therapeutics.
Curie, Univ. Pierre & Marie EP 1 092 436
Modified tendon cells
Human tendon cell preparations; for genetic modification to restore tendons and ligaments [in French].
Dartmouth College WO 01/25400
Modulating ATP-binding proteins
Methods an compositions for modulating ATP-binding cassette transmembrane reporter protein expression.
Eberhard Karls Univ. WO 01/25441
Tumor-specific vector with heterologous therapeutic genes driven by telomerase catalytic subunit/cycline A promoters.
Eli Lilly WO 01/25428
Human leptin homolog, encoding gene sequences; for treating obesity.
Emalfarb, M.A. WO 01/25468
Drug target screens
High-throughput screening of expressed DNA libraries in filamentous fungi; for identifying drug targets.
Exiqon WO 01/25478
Mismatched DNA assay
Increasing the specificity of oxy-LNA oligonucleotides; for discriminating between matched and mismatched nucleic acids.
Florida State Univ. WO 01/25421
Cystic fibrosis drug screen
Materials and methods for detecting the interaction of CFTR polypeptides; for screening cystic fibrosis drugs.
Fraunhofer Res. Inst. EP 1 092 769
Peptide tags for purification
Polypeptide tags fused to proteins of interest; for detection and purification of proteins [in German].
Fuso Pharma EP 1 092 767 & 1 092 772
Neurosin and LAR phosphatase antibodies
Monoclonal antibodies to neurosin, a serine protease, and LAR phosphatase; for neuronal diseases and thyroid cancer.
Genaissance Pharma WO 01/25194 & 25245
Drug target isogenes
New Haven, Conn.
Polymorphisms in the serotonin receptor 1B and death associated protein 6 genes; for finding drug targets.
Genentech WO 01/25433
S. San Francisco
Proteins related to angiogenesis and neovascularization, encoding gene sequences; for diagnostics and therapeutics.
Genovo WO 01/25462
High titer vectors
Sharon Hill, Penn.
Adenoviruses having the p5 promoter of the rep gene replaced by a minimal promoter; for producing high titers of vectors.
Georgetown Univ. WO 01/25450
Tumor immuno-gene therapy
Vector expressing a soluble costimulatory factor, encoding gene sequences; for enhancing T cell response to tumors.
Glaxo WO 01/25792
Vaccination T cell response
Methods for assessing in vivo T cell response after DNA vaccination.
Greenovation Plant Biotech WO 01/25456
Protein production in moss
Production of heterologous proteins in moss plants; for making therapeutics.
Human Genome Sciences WO 01/24815 & 25252
Human plasminogen-like and tissue plasminogen activator-like protease gene sequences, encoded proteins, antibodies.
Iowa, Univ. of WO 01/25465
Episomal AAV vectors
Iowa City, Iowa
Adeno-associated virus DNA segments that confer increased episomal stability and persistence.
Isis Innovation WO 01/25461
Utrophin gene promoter; for linkage to reporter genes in order to find utrophin modulators.
Japan Sci. & Technol. WO 01/24627
Anti-allergy drug transgenics
Transgenics expressing human hematopoietic prostaglandin D2 synthase; for testing anti-allergy drugs.
Kurokawa, K. WO 01/24628
Transgenics expressing megsin; for modeling mesangial cell proliferative nephritis.
Kyowa Hakko Kogyo WO 01/25427
Shear stress-response gene
Shear stress-response gene sequences, encoded protein, antibodies; for vascular disease.
Lexicon Genetics WO 01/25430
G protein coupled receptors
The Woodlands, Texas
Human G protein coupled receptors, encoding gene sequences; for developing therapeutics.
Lipoxen WO 01/24773
Oral liposomal vaccines
Liposome entrapped DNA encoding antigens; for oral vaccine administration that increases IgA levels.
Mass. Gen. Hosp. WO 01/25281
Na+K+-ATPase ligand antibodies
Oaubain-specific monoclonal antibodies, fragments; for diagnostics and therapeutics related to Na+K+-ATPase.
Maxygen WO 01/25277
Single-chain oligomeric TNF-a polypeptides as antagonists to the extracellular ligand-binding domains of receptors.
Maxygen WO 01/25438
Redwood City, Calif.
Interferon-a homologs, encoding gene sequences; for developing diagnostics and therapeutics.
Medicago WO 01/25454 & 25455
Transgene transcription that is controlled by the presence of nitrogen.
Merck WO 01/25251
Modulating cell wall synthesis
Pseudomonas aeruginosa MraY gene, encoded protein; for modulating cell wall peptidoglycan synthesis.
Merck WO 01/25258
Potassium channel subunit
Human inwardly rectifying potassium channel subunit, encoding gene sequences; for finding modulators.
Merck WO 01/25423
Cytoplasmic calcium binding protein
Splice variant of head trauma induced cytoplasmic calcium binding protein, encoding gene, protein production methods.
Michigan, Univ. of WO 01/25484
Viral DNA binding modulation
Ann Arbor, Mich.
Methods and reagents that modulate the binding of viral DNA to genomic host DNA; for gene therapy.
Millennium Pharma WO 01/25409
Human lipase proteins, encoding genes, variants, fragments, derivatives; for glyceride metabolism modulators.
Millennium Pharma WO 01/25448
Adenylate cyclase, encoding gene sequences, antibodies, fusions, antigenic peptides; for modulator screens.
Minnesota, Univ. of WO 01/25440
C3 binding polypeptide of Group B Streptococcus that is implicated in adhesion and virulence, antibodies.
Molecular Sciences Inst. WO 01/25794
Protein fingerprinting system that uses hydrodynamic focusing, atomic force microscopy, and electrophoresis.
NIH (Natl. Inst. Hlth.) EP 1 092 770
Human cancer antigen
Human cancer antigen from tyrosine-related proteins 1 and 2, encoding gene sequences; for cancer immunotherapy.
NIH (Natl. Inst. Hlth.) WO 01/25407
Topoisomerase 1 inhibitor assay
Tyrosine-DNA phosphodiesterase, encoding gene, antibodies, antisense; for finding topoisomerase 1 inhibitors.
New Jersey, Univ. Med. & Dent. WO 01/25486
RNA binding agent identification
New Brunswick, N.J.
Methods for identifying RNA binding compounds; for modulating protein production.
North Carolina, Univ. of WO 01/25253
Temperature-sensitive AAV vectors
Chapel Hill, N.C.
Temperature-sensitive adeno-associated virus Rep 68/78 proteins; for regulating vector packaging and delivery.
Ohio State Univ. WO 01/24765
HCG antibodies for cancer
Antigenic modification of human chorionic gonadotropin, linkage to carriers; for making antibodies to treat cancer.
Oxford Biomedica WO 01/25466
Producing retroviral vectors
Producer cell line with integrated recombinase recognition sequences; for producing retroviral vectors.
Pasteur Inst. EP 1 092 779
Inducing cell-mediated immunity
Lentiviral vectors having inserted heterologous genes; for inducing cell-mediated immune responses.
Paul Erlich Inst. WO 01/25415
Targeting T cells
Gene transfer in human lymphocytes using retroviral scFV cell targeting; for T cell diseases.
Penn State Univ. WO 01/25282
University Park, Penn.
Interleukin-13 mutants, encoding gene sequences; for use as activity modulators.
Pfizer EP 1 092 727
G-protein receptor, encoding gene sequences, variants, homologs, analogs, fragments, and derivatives.
Quark Biotech WO 01/25488
Enriching natural antisense
Enriching natural antisense mRNA by DNA polymerase treatment of sense-antisense hybrids.
Rockefeller Univ. WO 01/25431
Vomeronasal-like pheromone receptors
Vomeronasal-like pheromone receptors, encoding gene sequences, allelic variants; for finding modulators.
Schering WO 01/25432
Histamine receptor, encoding gene sequences, antigenic fragments, production methods; for modulator assays.
Schering WO 01/25446
Serine protease, encoding gene sequences, production methods; for diagnostics and therapeutics.
Schrotz-King, P., et al. WO 01/25268
Human seizure-related proteins, encoding genes, antibodies; for neurological disease diagnostics and therapeutics.
SmithKline Beecham WO 01/24625
Uncoupling protein transgenics
Transgenic rodents having an inserted human uncoupling protein 3 gene; for UCP3 expression.
SmithKline Beecham WO 01/24635 & 24819
Bacterial asuE and ysxC polypeptides, encoding genes, recombinant production methods; for antibacterial screens.
SmithKline Beecham WO 01/25280
G-protein coupled receptor
G-protein coupled receptor, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Solvay Pharma WO 01/25269
G-protein coupled receptor
Human G-protein coupled receptor, encoding gene sequences, antibodies, transgenics; for diagnostics and therapeutics.
Source Precision Medicine WO 01/25473
Calibrated gene expression
Using calibrated gene expression profiles to characterize a biological condition.
Spanish Sci. Invest. Counc. WO 01/25442
Tumor-associated DNA polymerase
DNA polymerase lambda, isoforms associated with tumors; for cancer diagnostics and therapeutics.
Sumitomo Electric EP 1 092 783
Cancer chromosome modifications
Detection of amplifications and deletions in chromosomes in various cancers; for diagnosis.
Symbicom EP 1 092 774
Lyme disease antigens
Borrelia burgdorferi outer membrane antigen OspA and related antigenic polypeptides, encoding genes; for Lyme disease.
Tigenix WO 01/25402
Skeletal precursor cells
Isolation of skeletal precursor cells using cartilage-derived morphogenetic protein markers; for tissue repair.
Urogenesys WO 01/25434
Prostate cancer receptor
Santa Monica, Calif.
G protein-coupled receptor upregulated in prostate cancer, encoding gene sequences; for diagnostics and therapeutics.
Utah, Univ. of WO 01/24681
Long QT syndrome gene mutations
Salt Lake City
Alterations in the genes involved in long QT syndrome; for diagnosing syncope, seizures, and sudden death prevalence.
Utah, Univ. of WO 01/25256
Salt Lake City
Tumor necrosis factor-like ligand, encoding gene sequences; for cancer diagnostics and therapeutics.
ZymoGenetics WO 01/25444
Human phosphodiesterase, encoding gene sequences; for detecting human chromosomal abnormalities.