Published April 27 & May 4 (EPO); April 28 (WO)
Agro-Tech InstitutePlastic-yielding WO 94/ 9146Wageningen, Neth. microbeAn Alcaligenes eutropus sp. that yields PHB (polyhydroxybutyrate) inmedium, with glycerol as sole carbon source.
Ajinomoto Co.Recombinant EPO 593 792TokyoL-threonineE. coli strain that produces more than 70 g/l of recombinant L-threonine in low-cost molasses-based medium.
Alabama, Univ. ofRetroviralWO 94/ 8454Birmingham, Ala.autoimmunity linkInsertion of a retroviral transposon into apoptosis gene suggeststherapeutic strategies for autoimmune diseases.
Algatech ABSweetener from algaWO 94/ 9122Uppsala, SwedenAlga-derived glucan lyase produces 1,5-anhydrofructose, for use asoxygen scavenger, anti-oxidant, sugar substitute.
Amoco Corp.Hydridization assaysWO 94/ 9159ChicagoInsertion elements, recombinant molecules, amplifiable nucleic acids,for hydridization assays.
Amrad Corp.GM-CSF receptorWO 94/ 9149Kew, Vic., Australia inhibitorMonoclonal antibodies that inhibit human granulocyte-macrophagecolony stimulating factor receptor bioactivity.
Bayer AGAIDS antisense EPO 594 881Leverkusen, GermanyantiviralBlocking HIV mRNA to prevent viral replication in hematopoietic cellswith antisense expression system [In German]
Bayer AGFungal infection EPO 595 167Leverkusen, GermanydiagnosisSpecific genomic probe to diagnose Candida albicans in a clinicalsetting. [In German]
Boehringer Ingelheim Malic enzyme in EPO 595 241Ingelheim, GermanytumorsInhibiting growth and replication of tumor cells by blocking a specificgene expressing malic enzyme. [In German]
Cangene Corp.Large-scale WO 94/ 9145Mississauga, Ont.transfectionDirect mass transfection of eukaryotic, prokaryotic or plant cells, byagitating fixed cells with DNA plus "particules."
Cetus Oncology Corp.IL-6 inhibitorWO 94/ 9138Emeryville, Calif.Multi-mutated interleukin-6 muteins act as IL-6 receptor antagonists;for treating, e.g., sepsis, multiple myeloma.
Cold Spring Harbor Lab.Cyclin complexWO 94/ 9135Cold Spring Harbor, N.Y.Detection of cyclin complex rearrangement; to diagnose celltransformation, inhibit cell proliferation.
Colorado, Univ. of.Nucleic acid selectionWO 94/ 9158Boulder, Colo.Selecting nucleic acids by physical structure; to detect single- ordouble-stranded DNA or RNA; e.g., to regulate gene expression.Columbia UniversityRetroviral producer WO 94/ 9120New York CitycellMammalian retroviral producer cell constructed by tranfectingpackaging cell with human multiple drug resistance gene.
Dana-Farber Cancer Inst.CD26 bindingWO 94/ 9132BostonHuman CD26 polypeptide or fragment that can disrupt bindingbetween CD26 and CD45.
Dartmouth CollegeRecombinant ACATWO 94/ 9126Hanover, N. H.Nucleic acid encoding bioactive acyl coenzyme A:cholesterolacyltransferase (ACAT).
Eli Lilly & Co.Dipeptide removalEPO 595 476IndianapolisA dipeptidylaminopeptidase from Dictostelium discodeum slime mold;removes dipeptides from precursor proteins.
Genentech, Inc.TNF receptor mimicWO 94/ 9137S. San FranciscoMonoclonal antibodies against type 2 tumor necrosis factor receptor; tostimulate human T-cell proliferation.
Green Cross Corp.High-activity EPO 595 334Osaka, JapanpromoterMutant AOX2 promoter "is highly useful in an expression vectorallowing heterologous protein expression."
Guelph, Univ. ofSelf-incompatible rapeWO 94/ 9139Guelph, Ont.S-locus receptor kinase gene in a self-incompatible rape plant (Brassicanapus) line; to render a plant self-incompatible.
Hayashibara SKKMetastasis inhibitionEPO 594 311Okayama, JapanProtein with cancer-metastasis-inhibiting activity, cultured in host cellswith inducer, e.g. BCG and lipopolysaccharides.
Idemitsu Kosan Co.Human procathepsinEPO 594 879TokyoMonoclonal antibody reactive with human procathepsin L, or five of itsconstituent peptides; for diagnosis, therapy.
INSERM (Hlth/Med. Res.)SerotoninergicWO 94/ 9130ParisreceptorRecombinant polypeptides, known as 5HT2C, having a serotoninergicreceptor activity.
Inst. Belka Akad. NaukCell-free polypeptidesEPO 593 757Puschino, RussiaPolypeptides obtained in a cell-free system containing exogenousRNA-polymerase, nucleic acids, ATP, GTP, amino acids.
Kettock LodgeCytomegalovirus WO 94/ 9136Aberdeen, U.K.monoclonalA humanized monoclonal antibody that binds to and neutralizescytomegalovirus. Its CDRs are non-human; FRs human.
Kikkoman Corp.Mink growth hormoneEPO 593 794Chiba, JapanRecombinant mink growth hormone gene; its expression product.
Kitasato InstituteCholesterol controlWO 94/ 9147TokyoSubstance FO-1289, produced by culturing Aspergillus sp, inhibitsacylcoenzyme; to prevent, treat cholesterol build-up.La Jolla Cancer Res.Inhibiting cell WO 94/ 9160La Jolla, Calif.replicationConverting a pathologic, hyperproliferative human cell to its non-malignant phenotype by inserting gene encoding adenovirus.
Loma Linda Univ. Solid-tumor antibodyWO 94/ 8615Loma Linda, Calif.Monoclonal antibody against a native aminomalonic acid-containingmoiety; for solid-tumor diagnosis, therapy.
Mallinckrodt MedicalRestenosis therapyWO 94/ 9128St. LouisAntisense human macrophage chemoattractant protein (MCP-1) toimage, treat, areas of vascular restenosis
Mass. General Hosp.Fruit-ripeningWO 94/ 8449BostonDNA encoding an ACC crucifer synthase; ethylene-inducing promoterto express proteins, regulate fruit-ripening.
Mass. General Hosp.Immortal chondrocytesWO 94/ 9118BostonImmortalizing chondrocytes that retain differentiation; for gene therapyof cartilaginous diseases, inhibiting vascularization.
Mass. General Hosp.Heterodimer inhibitorsWO 94/ 9133BostonFusion proteins to screen for dimeric protein partners, identifyheterodimer inhibitors, prevent oncogenic activation.
Merck & Co.Endothelin receptorWO 94/ 9116Rahway, N. J.DNA encoding human endothelin receptor subtypes, expressed in CHOcells "are useful pharmacological tools."
Miltenyi Biotec, Inc.Direct cell selectionWO 94/ 9117Auburn, Calif.Cells can be labeled with their products by binding to product partner;for selection by presence, absence or amount.
Mogen Intl.Plant transgenesWO 94/ 9143Leiden, Neth.Genetic moderation or restoration of plant phenotypes by twotransgenes; to delete, replace, a specific plant function.
N. Y. Blood CenterBlood purificationWO 94/ 9121,123New York CityPurification from avian liver of enzyme a-N-acetylgalactosaminidase,which removes A antigens from blood products.
Neurospheres Ltd.Nerve remyelinationWO 94/ 9119Calgary, AlbertaRemyelination of neurons by human neural stem cells culturedto grow oligodendrocyte precursors.
NIH (Natl. Insts. Hlth.)Supercoiled DNAWO 94/ 9127Bethesda, Md.Supercoiled "minicircle" DNA containing single promoter, usingintegrative recombination system of lambda phage.
NIH (Natl. Insts. Hlth.)RNA cleavageWO 94/ 9129Bethesda, Md.Chimeric molecule to cleave specific RNA strands combines antisenseoligonucleotide and oligoadenylate molecule.
NIH (Natl. Insts. Hlth.)P. carinii vaccinesWO 94/ 9141Bethesda, Md.Genes encoding surface glycoprotein of human Pneumocystiscarinii; to prepare vaccines against this AIDS infection.NIH (Natl. Insts. Hlth.)Prostate-aimed WO 94/ 9150Bethesda, Md.monoclonalsAntibodies to prostate-associated antigen; to aim conjugatedcompounds at cancerous prostate cells; for diagnosis, therapy.
Pasteur InstituteMalaria vaccineWO 94/ 9140ParisPlasmodium falciparum antigen induces protective antibodies thatblock erythrocyte phase of malarial parasite; for vaccine.
Pitman-Moore, Inc.Helminth vaccinesWO 94/ 9142Mundelein, Ill.Thiol proteases with cathepsin L activity, derived from Fasciolahepatica fluke; for vaccines against helminth parasites.
Pronova BiopolymerDesigner alginatesWO 94/ 9124Trondheim, NorwayDNA encoding enzymes with mannuronan C-5-epimerase activity; toproduce alginates with definite G/M ratio, block structure.
Regeneron Pharm.Recombinant CNTFWO 94/ 9134Tarrytown, N. Y.Human ciliary neurotrophic factor (CNTF) modified by amino acidsubstitution; for treating nervous-system disorders.
Sagami Chem. Res.Eicosapentaenoic acidEPO 594 868TokyoRecombinant eicosapentaenoic acid, "useful as medicine, pesticide,food, feed and the like."
Scotgen Ltd.Bispecific proteinWO 94/ 9131Aberdeen, U. K.A recombinant, humanized, bispecific binding protein, incorporatingspecificities of two antibody binding regions.
Solvay Animal Health.Porcine vaccineEPO 595 436Mendota Hts., Minn.A recombinant vaccine that protects pigs from a virus causingporcine respiratory and reproductive disease.
Sumitomo Metal Inds.Pre-C hepatitisEPO 593 789Osaka, JapanRapidly judging and quantifying, by PCR amplification, pre-Cmutation of hepatitis B virus
Tonen Corp.FK506-binding protein EPO 594 847TokyoMass-producing human FK506-binding protein withpeptidylprolylisomerase activity; to screen immunosuppressants.
Toray IndustriesMHC antigenWO 94/ 9148TokyoProducing a major histocompatibility antigen class II protein, as foundon antigen-presenting cells; superantigen detection.
Yeda R&D Co.Essence of garlicWO 94/ 8614Rehovot, IsraelRecombinant, bioactive garlic allinase; food products, pharmaceuticalcompositions.
Zeneca Ltd.Improved plant starchWO 94/ 9144LondonTransgenic cereal plants with improved ability to synthesize structure-altered starch at extreme temperatures.
_Compiled by David N. Leff
(c) 1997 American Health Consultants. All rights reserved.