Published November 24 (EPO); November 18 (WO); November 24 (GB)
Acacia Biosciences WO 99/58720
Gene expression profiling
Methods, systems, and instrumentation for quantifying the relatedness of gene expression profiles.
Ariad Gene Therapeutics WO 99/58700
Multiviral compositions and methods for using them in gene therapy protocols.
Aventis Res. & Technol. WO 99/58647
Human deadenylating nuclease, encoding gene sequence, functional variants.
Axys Pharma WO 99/58669 & 58677
S. San Francisco
GTP-binding proteins, encoding gene sequences, antibodies, polymorphisms, transgenics, production methods.
Battelle Mem. Inst. WO 99/58699
Coagulation factors from plants
Production of human blood coagulation factors in transgenic plants and plant cell cultures.
Baylor Coll. Med. WO 99/58156
Breast cancer gene therapy
Intraductal injection of adenoviral gene therapy vectors into the mammary gland; for cancer therapy
Biomarin Pharma WO 99/58650
Fungal infection therapy
Isolation of lytic enzymes from microorganisms; for use in treating fungal infections.
Bristol, Univ. of GB 2 337 519
Neuronal promoter transgenics
Adenoviral vectors with neuronal cell-specific promoters and a tetracycline analog responsive element; for transgenics.
Bristol, Univ. of WO 99/58145
Infectious disease vaccines
EtxB, CtxB, or VtxB free from whole toxin; for affecting GM1-binding for use as an immunmodulator for vaccines.
Cadus Pharma WO 99/58670
G-protein signaling activators
Ras-related activators of G-protein signaling, encoding gene sequences; for screening modulators.
California, Univ. of WO 99/58559
TNF signal modulation
Proteins causing enzymatic cleavage and shedding of TNF receptors for TNF signal transduction modulation.
California, Univ. of WO 99/58694
Methods of forming protein-linked lipidic microparticles having increased shelf-life and high transfection activity.
Cambridge Univ. Tech. Services WO 99/58572
Inhibiting B cell activation
Immunoglobulin-derived binding molecules that do not trigger complement mediated lysis; for B cell activation inhibition.
Catholic Univ. WO 99/58147
NK cell apoptosis
Louvain La Neuve, Belgium
Apoptosis of naive human NK cells by crosslinking their Fc-gamma-RIIIa molecules with a humanized monoclonal antibody.
Chiron WO 99/58675
Human genes, encoded proteins, probes, antisense, antibodies; for diagnostics and therapeutics.
CNRS (Natl. Ctr. Sci. Res.) WO 99/58693
T cell modulation
Complex formed by a peptide and a major histocompatibility complex on the surface of phages; for affecting T cells.
Ctr. Plant Reproduction EPO 959 133
Gene expression inhibition
Inhibition of gene expression using nucleotide sequences targeted to the desired gene and having inserted sequences.
Cis Bio Intl. WO 99/58980
Human chromogranin A assay
Immunologic assay for human chromogranin A using monoclonal or polyclonal antibodies and sandwich techniques.
Clontech Labs WO 99/57992
Recombinant protein purification
Palo Alto, Calif.
Introducing metal ion affinity sequences into recombinant protein fusions; for ease of purification.
Cortecs WO 99/58563
Moraxella catarrhalis antigens; for use as bacterial infection diagnostics and therapeutics.
Cramer, D.V., et al. WO 99/58157
Transplant rejection therapy
Blocking the expression of genes encoding antibodies that cause transplanted tissue rejection.
DCV WO 99/58133
Egg products obtained from hyperimmunized birds; for treating and preventing diarrhea.
Diatech WO 99/58661
Introduction of mutations into mRNAs placed in an in vitro translation system; for protein mutation and evolution.
DNAVec Research EPO 959 134
Artificial mammalian chromosome
Artificial yeast chromosome libraries having mammalian replication origins, centromeres, and telomeres.
Eidgenossische Tech. School WO 99/58570
Blood vessel occlusion
Radiolabeled, photoactivatable antibodies to fibronectin ED-B epitope; for light-mediated blood vessel occlusion.
Epicentre Technol. WO 99/58717
Identifying DNA sequences
Chemical modification of guanine residues in DNA; for enzymatic cleavage and fragment separation.
Epimmune WO 99/58658
Nucleic acids encoding multiple CTL and HTL epitopes and MHC targeting sequences; for stimulating immune responses.
Galilaeus WO 99/58544
Hybrid anthracyclines derived from genetically engineered Streptomyces galilaeus strains.
Garvan Inst. Med. Res. WO 99/58711
Early onset Alzheimer's
Detection of Alzheimer's disease markers and allelic variation on chromosome 5; for early onset diagnosis.
Gemini Research WO 99/58715
Nitric acid synthase gene polymorphisms; for genotyping and detecting a propensity towards hypertension.
Genecure WO 99/58726
Replication-defective HIV particle pseudotyped with vesicular stomatitis virus G protein; for immunoresponse.
Genentech WO 99/58573
S. San Francisco
Agents that block interactions between intracellular adhesion molecules; for inhibiting inflammation.
Genera WO 99/58646
Genetically-modified fibroblasts expressing a muscle lineage commitment gene; for protein expression and therapeutics.
Genetic Engineering & Biotech Ctr. EPO 959 079
Peptides derived from gonadotropin releasing hormone; for reversible castration.
Genetics Inst. WO 99/58642
Secreted proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Genetix Pharma WO 99/58701
Recombinant retrovirus production
Lentiviral packaging cells that produce recombinant retroviruses that are free of detectable helper viruses.
Glaxo WO 99/58679
CD23 antibodies and altered antibodies, derivatives, production methods; for treating autoimmunity.
GX Biosystems WO 99/58652
Use of genes encoding cytotoxins for transfection of cells to be used as vaccines and in biological containment.
Hahnemann Univ. WO 99/58640
T cell cancer therapy
Human oncogene having multiple copies in T cell cancer, encoded protein, antisense, antibodies; for therapy.
Harbor-UCLA WO 99/58691
Recombinant a-L-iduronidase, fragments, mutants, production methods; for treating mucopolysaccharidosis I.
Harvard Univ. WO 99/58673
Geminin, an inhibitor of DNA replication and inducer of neurogenesis, encoding gene; for neuronal therapeutics.
Hitachi EPO 959 141
Rarely expressed genes
Methods of preparing nucleic acid samples for the analysis of the rarely expressed genes.
Human Genome Sciences WO 99/58660
97 secreted proteins
97 human secreted proteins, encoding gene sequences, antibodies; for diagnostics and therapeutics.
Immunex WO 99/58674
Treating bone loss
Isolated soluble RANK receptors, encoding gene sequences; for inhibiting osteoclast activity.
Immunex WO 99/58676
Semaphorins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Incyte Pharma WO 99/58558
Cell signaling proteins
Palo Alto, Calif.
Cell signaling proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/58672
Pro-monocyte associated protein
Palo Alto, Calif.
Human pro-monocyte associated protein, encoding gene, antibodies, modulators; for diagnostics and therapeutics.
Incyte Pharma WO 99/58692
Palo Alto, Calif.
Human apoptosis-associated proteins, encoding genes, antibodies, modulators; for diagnostics and therapeutics.
Innogenetics WO 99/58638
TT virus infection therapy
TT virus sequences that are unique to several subtypes, encoded proteins; for infection diagnosis and treatment.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 99/58645
Cellular tumor vaccines
Apoptotic bodies from cancer cells that contain unmasked tumor antigens; for integration into monocytes.
Introgene EPO 959 135
Targeted gene delivery
Mutant viral-derived protein used as a ligand for targeting gene delivery vehicles.
Introgene EPO 959 136
Targeted gene delivery
Virus-like particles with a cationic amino acid transporter ligand on their surfaces; for targeted gene delivery.
Isis Innovation WO 99/58557
Cross-linked peptides derived from HLA extracellular domains; for spondyloarthropathy therapeutics.
Isis Pharma WO 99/58719
Finding interaction sites
Identifying molecular interaction sites in RNA by using highly conserved sequences to find secondary structure.
Isis Pharma WO 99/58722 & 58947
RNA interaction sites
Molecular interaction sites of RNA, methods for identifying ligands for these sites and their modulators.
Karolinska Innovations WO 99/58565
Cystatin-related protein having homology to tumor inhibiting cystatins, encoding gene; for testes tumor therapy.
Karolinska Innovations WO 99/58566
Inhibiting p53 binding
Inhibition of DNA sequence-specific binding activity of p53 by fragments of p53; for screening mimics.
Kimeragen WO 99/58702 & 58723
Reaction of recombinagenic oligonucleotides in a cell-free system containing a cellular extract and test duplex DNA.
Krebs Res. Ctr. WO 99/58712
Detecting genes and their expression using amplification in the presence of gene-specific primers.
Kyowa Medex WO 99/58716
Gene sequence quantitation
Quantitation of specific gene sequences by hybridizing single-stranded fragments to carrier-bound DNA probes.
Le, X.-C., et al. WO 99/58971
Carcinogen exposure detection
Detecting single-base DNA changes using fluorescently labelled proteins; for detecting carcinogen exposure.
Life Technologies WO 99/58724
Nucleic acid synthesis
Peptides having ribonuclease activity; for PCR-based nucleic acid synthesis methods.
Ludwig Inst. Cancer Res. WO 99/58546
Tumor-associated antigen encoded by the reverse strand of a ubiquitously expressed gene, fragments, homologs.
Maryland, Univ. of WO 99/58146
Typhoid fever vaccines
Attenuated Salmonella typhimurium mutants constitutively expressing Vi antigens; for typhoid fever vaccines.
Maryland, Univ. of WO 99/58649
College Park, Md.
Nucleic acids and vectors encoding isoprenoid synthesis enzymes; for modulating cellular isoprenoid levels.
Maryland, Univ. of WO 99/58727
Capsid protein detection
Capsid protein detection using matrix-associated laser desorption/ionization time-of-flight mass spectrometry.
MRC (Med. Res. Counc.) WO 99/58655
Recombinant virus selection
Selection of recombinant viruses using display of heterologous proteins as fusions with coat proteins.
Merck WO 99/58662
Fusion protein having an immunoglobulin Fc domain linked to erythropoietin; for efficient protein production.
Michigan, Univ. of WO 99/58656
DNA delivery from matrices
Ann Arbor, Mich.
Use of three-dimensional structural matrices for prolonged release of DNA and migration of cells into the matrices.
Micromet WO 99/58678
Dendritic cell antibodies
Antibodies to human dendritic cell populations; for cell isolation and T cell activation.
Millennium Pharma WO 99/58641
G-protein-coupled receptors with homologies to neurotensin-2 receptors, encoding gene sequences; for therapeutics.
Miltenyi Biotech WO 99/58977
T cell selection
Direct selection of antigen-specific T cells using cell separation and antigen-stimulated product secretion.
Myriad Genetics WO 99/58548
Tumor cell growth suppression
Salt Lake City
MMSC2 gene, encoded protein that interacts with MMAC1; for screening drugs that suppress tumor cell growth.
Natl. Inst. Food & Agricult. WO 99/58725
Viral DNA identification
PCR-based amplification of viral DNA from samples of viral particles; for infection diagnosis.
Navarra Inst. Science & Technol. WO 99/58143
Liver viral infection therapy
Use of interferon-a5 in the treatment of viral infections in livers.
New England Biolabs EPO 959 131
AgeI restriction endonuclease
Recombinant gene sequences encoding the AgeI restriction endonuclease and methyltransferase, production methods.
Norsk Hydro WO 99/58552
Peptides from cancer-related protein products of frameshift mutated genes; for eliciting T cell-based cancer immunity.
Norsk Hydro WO 99/58564
Frameshift mutants of _-amyloid precursor protein and mutant ubiquitin-B associated with Alzheimer's and Down syndrome.
Ono Pharma EPO 959 078
Peptides that are specific substrates of human pepsin I; for assaying human pepsin I and pepsinogen I.
Ono Pharma WO 99/58668
Hematopoietic cell regulatory proteins
Proteins having hematopoietic cell regulatory activity, encoding gene sequences; for diagnostics and therapeutics.
Oxford BioMedica GB 2 337 520
Retroviral targeting vector
Retroviral vector having part of the envelope and rabies G protein coding regions; for targeted cell delivery.
Pasteur Merieux WO 99/58561
Hepatitis C infection therapy
Peptides that imitate a conformational epitope of hepatitis C virus; for infection diagnosis and therapy.
Pasteur Inst. WO 99/58714
Mutant strains of gram-negative bacteria that constitutively secrete proteins; for identifying modulators of secretion.
Purdue Univ. WO 99/58134
Nucleic acid delivery
West Lafayette, Ind.
Polymeric polysaccharide and alginate microparticles; for nucleic acid delivery.
Quark Biotech WO 99/58718
Isolation of differentially expressed or developmentally regulated gene sequences from cell compartments.
Queensland, Univ. of WO 99/58569
Single stage competitive inhibitors of plasmin from the Australian brown snake, encoding genes; for blood loss.
Res. Corp. Technol. WO 99/58671
Human homologs of yeast longevity assurance gene, encoded protein, antisense; for therapeutic over-expression.
Rigel Pharma WO 99/58663
IgE synthesis modulation
S. San Francisco
Methods and compositions for screening modulators of immunoglobulin (Ig)-E synthesis and secretion.
Rosetta Inpharmatics WO 99/59037
Protein activity determination
Determining protein activity levels in cells using gene expression profile analyses.
Salk Inst. WO 99/57956
FGF-2 expression regulators
La Jolla, Calif.
Genes for peptides regulating fibroblast growth factor (FGF)-2 expression, encoded regulators, variants.
Salk Inst. WO 99/58135
Inhibiting tumor suppressors
La Jolla, Calif.
Alteration or inhibition of the nuclear export signal of tumor suppressor protein; for treating cancers.
Salk Inst. WO 99/58155
Modulating gene expression
La Jolla, Calif.
Use of modified ecdysone receptors to modulate exogenous gene expression.
Shanghai Children's Hosp. WO 99/58703
Preparation of transgenic sheep using in vitro microinjection techniques.
Sloan-Kettering Inst. WO 99/57981
Administration of an immunogenic extracellular fragment with an antigenic carrier; for active vaccination.
SmithKline Beecham WO 99/58562
BASB009 polypeptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/58567
GABAB1b receptor peptides
GABAB1b receptor peptides, encoding genes, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/58568
GRPW receptor peptides
GRPW receptor peptides, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/58667
Rhotekin, a putative target for Rho, encoding gene sequences; for diagnostics and therapeutics.
SmithKline Beecham WO 99/58682, 58684 & 58685
Moraxella catarrhalis proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 99/58683
Neisseria meningitidis proteins, encoding gene sequences, production methods; for diagnostics and therapeutics.
Southern California, Univ. of WO 99/58651
Modified fibrinolytic enzymes
Size-modified fibrinolytic enzymes modified by attaching large organic molecules to the enzyme.
Stichting Inst. WO 99/58680
Human antibody with Factor VIII specificity, encoding gene sequence; for treating hemophilia.
Stunzenes, V. GB 2 337 462
Introduction of mRNAs into patient cells; for directly inducing immunity.
Takara Shuzo EPO 959 132
Leukemia diagnosis gene
Gene sequence encoding a receptor type protein kinase and having a tandem duplication; for diagnosing leukemia.
Telethon Fdn. WO 99/58556
Hereditary spastic paraplegia gene
Hereditary spastic paraplegia associated gene, encoded protein; for diagnostics and therapeutics.
Tosoh EPO 959 077
Optically active DNA
Optically active DNA probe having a phosphonic diester linkage and a fluorescent intercalative dye moiety.
Tsubota, K., et al. EPO 959 129
IL-10 formation inhibitors
Treating exocrine gland diseases by inhibiting interleukin (IL)-10 formation, transgenics for screening inhibitors.
Urogenesys WO 99/58560
Prostate cancer staging
Santa Monica, Calif.
Prostapin, encoding gene sequences; for diagnosing and staging prostate cancer.
Virginia, Univ. of WO 99/58665
Prostate disease markers
Isolation of fetal urogenital sinus gene sequences; for diagnosis of human prostate disease.
Webb-Waring Inst. Biomed. Res. WO 99/58547
Modified superoxide dismutase
Genetically modified manganese superoxide dismutase, encoding gene sequence; for treating oxidative damage.
Whitehead Inst. Biomed. Res. WO 99/58664
Nucleic acid separation
Separation of target nucleic acid molecules using functional group-coated magnetically responsive particles.
Whitehead Inst. Biomed. Res. WO 99/58721
Multiplex DNA amplification
Simultaneous amplification of a large number of target sequences using chimeric primers.
Zeneca WO 99/58666
Potassium channel modulators
Potassium channel subunit, encoding gene sequence; for identifying modulators.
- Compiled by Chester A. Bisbee