December 27 (EP & GB); December 21 (WO)
Abbott Labs WO 00/77206
Mycostatin gene promoter
Abbott Park, Ill.
Mycostatin gene promoter sequences; for finding gene expression modulators that can prevent muscle loss.
Abgenix WO 00/76310
Human antibody transgenics
Transgenic animals that produce specific isotypes of human antibodies using non-cognate switch regions.
Alabama, Univ. of WO 00/76541
Immunogenic combinations of two or more pneumococcal surface proteins; for intranasal administration to treat infection.
Alabama, Univ. of WO 00/77217
Recombinant gene expression
Nodavirus-based DNA vector; for driving abundant expression of foreign genes in a wide variety of cells.
Anadys Pharma WO 00/77215
Chromatin remodeling factor
Chromatin remodeling factor cdc68p from Candida yeast, encoding gene sequences; for identifying antifungals.
AstraZeneca WO 00/77200
Receptor interacting protein, encoding gene sequences; for identifying apoptosis modulators.
AstraZeneca WO 00/77201
Apoptosis inhibitor livin, encoding gene sequences; for finding modulators and developing therapeutics.
AstraZeneca WO 00/77251
DNA profiling assays performed on spermatozoa and epithelial cells isolated using specific antibodies.
Auckland Uniservices WO 00/76497
Auckland, New Zealand
Immunotherapeutic having T cell costimulatory and tumor growth-restricting agents; for cancer therapy.
Aventis Pasteur WO 00/76587
Streptococcus pneumoniae PspA antibodies; for infection treatment.
Aventis Pasteur WO 00/77243
Infectious virus assay
Methods for discriminating reverse transcriptase activity from cells and infectious viruses using PCR methods.
Aventis Pharma WO 00/76450
Recombinant adenoviral vectors having a gene encoding a sodium-iodide symporter; for metabolic radiotherapy.
Aventis Pharma WO 00/77190
Induction of vascular endothelial growth factor by the serine/threonine protein kinase AKT; for angiogenesis.
Barber, G.N., et al. WO 00/77205
Human nuclear factors
Human nuclear factors associated with double-stranded RNA, encoding gene sequences; for developing modulators.
Baylor Coll. Med. WO 00/76552
Modulating leptin activity
Methods and compositions for controlling bone formation via modulation of leptin activity; for bone therapeutics.
Biocrystal WO 00/76319
B cell antigen vaccines
Vaccines made from idiotypes of antibodies that bind to epitopes of specific shed antigens from B cells.
Biopharm WO 00/77195
EGF-like growth factor ligands
EGF-like growth factor ligands, encoding gene sequences, antibodies, modulators; for therapeutics.
Boehringer Ingelheim EP 1 063 294
Parkinson's disease-associated genes, encoded proteins; for diagnostics and therapeutics.
Boston Biomed. Res. WO 00/77178
Antibodies that catalyze _-amyloid hydrolysis at a pre-determined amide linkage; for plaque control.
Bristol-Myers Squibb WO 00/77227
Fibrin gel sealant; for applying to cells to trap nucleic acids and increase transfection efficiency.
Burnham Inst. WO 00/77207
Protein degradation protein
La Jolla, Calif.
Protein involved in protein degradation, encoding gene, antibodies, transgenics; for therapeutics.
California, Univ. of WO 00/77170
Ex vivo propagation of kidney tissue; for constructing a stable bioactive mammalian embryonic kidney.
CBD Technol. WO 00/77174 & 77175
Plant expression system
Expressing recombinant proteins in plants or their derived tissues or cells, subsequent purification.
CDC (Ctr. Disease Control) WO 00/77177
Isolation of a retrovirus from a human who was exposed to non-human primates; for vaccine development.
CDC (Ctr. Disease Control) WO 00/77254
Detection of Streptococcus pneumoniae using oligonucleotide probes, vaccination using antigenic proteins.
CDC (Ctr. Disease Control) WO 00/77486
Use of specific antigenic proteins from Treponema for the detection of syphilis infections at an early stage.
CNRS (Natl. Ctr. Sci. Res.) WO 00/77249
Production of complex mixtures of cDNAs by reverse transcription; for expression analysis.
Central Manchester Healthcare WO 00/77241
Heparanase assay using substrates bound to and immobilized on solid phase materials.
Cincinnati, Univ. of WO 00/77235
Rapid isolation of intact extrachromosomal plasmid DNA from bacteria using chaotropes.
Clingenix WO 00/77257
Differential expression arrays
Gene-specific arrays having 3' untranslated region probes; for differential expression assays.
Columbia Univ. WO 00/76320
Genration of xenospecific human suppressor CD8+CD28- T cells; for autoimmunity and transplant therapeutics.
Digital Gene Technol. WO 00/77166
Gastrointestinal inflammation genes
La Jolla, Calif.
Genes whose expression is modulated during gastrointestinal inflammation, encoded proteins; for therapeutics.
Diversa WO 00/77262
Preparation of nucleic acid libraries by non-random cloning and synthetic ligation reassembly; for directed evolution.
Exelixis WO 00/76308
Lipid metabolism models
S. San Francisco
Fruit fly and nematode animal model systems having modified sterol regulation pathways; for studying lipid metabolism.
Genentech WO 00/77037
S. San Francisco
Secreted and transmembrane proteins, encoding genes, chimeras, fusions, antibodies, production methods.
Genentech WO 00/77194
Peptide library scaffolds
S. San Francisco
Combinatorial peptide libraries having disulfide-constrained cyclic peptide scaffolds; for phage display.
Genetrol Biotherapeutics WO 00/77236
Enhanced cytokine production
Enhancing cytokine production in cells using a cytokine regulatory factor; for immune system therapy.
Genomic Profiling Systems WO 00/77260
Testing complex biological samples for the presence of specific organisms using specific DNA probes.
Glaxo EP 1 063 298
Transgenic Alzheimer's model
Mutated human APP895 gene driven by brain-specific Thy-1 sequences; for transgenic Alzheimer's model.
Guelph, Univ. of WO 00/77247
E. coli serotype assay
Gene sequence markers specific for E. coli serotypes; for diagnostics.
Henogen WO 00/77198
Tick salivary gland anti-coagulants
Tick salivary gland proteins, encoding gene sequences; for developing anti-coagulants.
Holthofer, H. WO 00/77044
Soluble nephrin-like proteins expressed by the pancreas and kidneys; for nephropathy diagnostics and therapeutics.
Human Genome Sciences EP 1 063 293
Transforming growth factor a11, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Icos WO 00/77179
Human poly(ADP-ribose) polymerase 2 (hPARP2), encoding gene sequences, antibodies; for modulator screens.
Immuno-Designed Molecules WO 00/76527
Phagocytic receptor complex
Complexes having a phagocytic receptor from monocyte-derived cells; for high affinity binding.
Imperial Cancer Res. Technol. WO 00/77252
Ovarian cancer diagnostic
Mutated forms of the Barx2 gene found in ovarian cancer; for diagnostics and therapeutics.
Incyte Genomics WO 00/77040
Intracellular signaling molecules
Palo Alto, Calif.
Intracellular signaling molecules, encoding gene sequences, antibodies, modulators; for diagnostics and therapeutics.
Incyte Genomics WO 00/77203
Lipocalin family protein
Palo Alto, Calif.
Lipocalin family protein, encoding gene, fragments; for diagnostics and therapeutics.
INSERM (Natl. Inst. Hlth. & Med. Res.) WO 00/77250
Circularization of oligonucleotides around double-stranded nucleic acid molecules; for diagnostics and therapeutics.
Iowa, Univ. of WO 00/77204
TLR4 locus polymorphisms
Iowa City, Iowa
Polymorphisms at the human TLR4 locus; for identifying individuals at increased risk for various diseases.
Italian Natl. Res. Counc. WO 00/76542
Use of antibodies against CD20 for treating graft versus host disease.
Janssen Pharma WO 00/77199
5-HT4 receptor, encoding gene sequences, transgenics; for developing therapeutics.
JMS EP 1 063 289
Liver cell clones
Liver cell clones isolated and grown for artificial livers and liver assist devices.
Johns Hopkins Univ. WO 00/77214
Cell cycle-related genes
Yeast genes that are differentially expressed during the cell cycle; for finding modulators and antifungals.
Keller, U. WO 00/77220
Non-ribosomal protein synthesis
Modifying peptide synthetases to N-methylate their substrate amino acids; for non-ribosomal protein synthesis.
Leiden State Univ. WO 00/77046
Male-specific transplantation antigen involved in graft rejection reactions; for developing therapeutics.
MacCallum Cancer Inst. GB 2 351 296
Keratinocyte stem cells
E. Melbourne, Australia
Use of integrins to enrich keratinocyte stem cells, isolated cell populations; for skin disease therapy.
Mass. Inst. Technol. WO 00/77213
Attenuation of bacteria by mutating bacA, identifying BacA transporter ligands; for vaccines.
Mass. General Hosp. WO 00/76456
Compositions and methods for modulating tissue fibrosis; for therapeutics.
Mass. General Hosp. WO 00/77233
Viral expression vectors
Complement-resistant non-mammalian DNA viruses, such as baculoviruses; for expressing exogenous genes.
Medimmune WO 00/76540
Immunogenic polypeptides from Streptococcus pneumoniae, encoding genes; for vaccines for pneumococcal infections.
Merck WO 00/77047
GnRH receptor ligand screen
Dog gonadotropin releasing hormone receptor, encoding gene; for identifying and screening GnRH receptor ligands.
Merck WO 00/77221
Hyaluronidase from the tropical leech Hirudinaria manillensis, encoding gene; for thrombotic therapy.
Millennium Pharma WO 00/77226
Cyclic nucleotide phosphodiesterase
Human cyclic nucleotide phosphodiesterase, encoding gene; for modulator and therapeutic screens.
Millennium Pharma WO 00/77239
Proteins with diagnostic and therapeutic uses, encoding gene sequences, fusion, antibodies, transgenics.
Myelos WO 00/77028, 77029 & 77033
D-amino acid cytokines
D-amino acid-based peptides derived from IL-3, IL-6, and leukemia inhibitory factor; for increased half-life.
NIH (Natl. Inst. Hlth.) WO 00/76537
Compositions of semi-allogeneic hybrid fusion immune system cells and immunogenic peptides; for HIV therapeutics.
NIH (Natl. Inst. Hlth.) WO 00/77042
PTH-1/2 receptor ligands
Parathyroid hormone-1 and -2 receptor ligands, encoding gene sequences; for developing therapeutics.
Neurosearch WO 00/77035
Potassium channels, encoding gene sequences, transgenics; for modulator screens.
New York, State Univ. of WO 00/77168
TGF_ signaling pathways
Stony Brook, N.Y.
Members of the Hect family of ubiquitin ligases that target BMP and TGF_/activin pathway-specific Smads.
New York Blood Ctr. WO 00/77024
Camello gene family
Camello gene family, encoded proteins, recombinant production methods, antibodies, transgenics.
New York Univ. WO 00/77238
Opioid G-protein coupled receptors
Heterodimeric opioid G-protein coupled receptors; for high-throughput assays to identify modulators.
Okamoto, H., et al. WO 00/77192
_ cell growth
Reg protein ligand expressed from a cDNA isolated from Langerhans cells; for regulating pancreatic _ cell growth.
Otsuka Pharma WO 00/77219
Determination of HIV subtype by amplifying sample nucleic acids and using an HIV-1 probe.
Pharmacia & Upjohn WO 00/77184
Crystallized caspase-8, identification of substrate binding pocket; for designing modulators.
Qxyz WO 00/77181
Synthetic enzyme genes
Assembling DNA units having the same restriction sites; for producing genes to make synthetic enzymes.
Rockefeller Univ. WO 00/77261
Alcohol dependence assay
High-throughput assays for expression of genes associated with alcohol dependence and addiction.
Rockefeller Univ. WO 00/77712
Finding protein homologs
Iterative methods for assessing the significance of similarities in protein sequences; for finding homologs.
Sloan-Kettering Inst. WO 00/77258
Prostate cancer diagnosis
Use of p27 protein from prostate cancers to diagnose tumor aggressiveness.
SmithKline Beecham WO 00/77180
Reductase, encoding gene sequences, recombinant production methods; for diagnostics and therapeutics.
SmithKline Beecham WO 00/77191
TNF-related receptor TR6
Tumor necrosis factor-related receptor TR6, encoding gene, recombinant production methods; for inflammatory disease.
SmithKline Beecham WO 00/77202
NOT1a protein, encoding gene, recombinant production methods; for diagnostics and therapeutics.
Spear, M.A., et al. WO 00/77167
Cancer gene therapy
Herpes simplex virus amplicon vector that are genetically modified to target cancer cells; for gene therapy.
Synaptic Pharma EP 1 063 291 & 1 063 292
a1 adrenergic receptors
Gene sequences encoding a1 adrenergic receptors, encoded receptors, antibodies, probes; for finding modulators.
Taisho Pharma EP 1 063 296
Nucleic acid enzyme having allosteric RNA-cleaving activity for a target RNA; for therapeutics.
Takeda Chemical WO 00/77045
GABA transporter modulators
GABA transporter-associated protein, encoding gene, transgenics; for screening modulators and developing drugs.
Temple Univ. WO 00/77245
Screening assay for cyclooxygenase-2 activity that uses cells whose COX-2 expression can be manipulated.
Texas, Univ. of WO 00/77038
p202 tumor suppressor
Use of p202 preparations to prevent transformation and proliferation of cancer cells.
Texas A&M Univ. WO 00/77041
Lyme disease vaccines
College Stn., Texas
Essential peptides from Borrelia burgdorferi decorin binding protein; for Lyme disease vaccines.
U.S. Navy WO 00/76539
Improved protective immunity
Immunization with a gene vaccine and a cytokine followed by recombinant pox virus; for improved protection.
Univ. Health Network WO 00/77031
MUC1 ligands isolated using phage display techniques; for making antibodies and treating cancer.
Vlaams Inst. Biotech WO 00/76309
Endothelial activation transgenics
Transgenics deficient in Gas6 in their endothelial cells that are resistant to activation by endotoxin and TNF-a.
Whitehead Inst. Biomed. Res. WO 00/77225
Insulin signaling molecule
Insulin signaling molecule SPANK, encoding gene sequences; for diagnostics and therapeutics.
Yale Univ. WO 00/77208
New Haven, Conn.
Drosophila taste receptors, encoding gene sequences; for identifying ligands.
ZymoGenetics WO 00/77209
Helical cytokine, encoding gene sequences, fusions; for diagnostics and therapeutics.