"We have, for the first time, a clear molecule that is released from human adipose tissue in obesity and has a direct effect on disease."
Charalambos Antoniades, professor of cardiovascular medicine and deputy head of the division of cardiovascular medicine at the University of Oxford and senior author in published research that shows that the release of Wnt5a from adipose tissue directly affected arteries through a signaling pathway that increased oxidative stress in the arteries
"If we think about how our platform and science work, that we're pathbreaking a new class of therapeutics for the future of medicine, it essentially means that we're tackling every disease that manifests itself as a result of the dysregulation of genes. We realized we must think in a transformative way and we thought also of the last letter in the Greek alphabet. It's the end-all. Once you have that, we figured you can transform all of medicine."
Mahesh Karande, president and CEO, Omega Therapeutics Inc., the latest creation from venture capital firm Flagship Pioneering
"The system in place now does not work for the Americans who depend on it – by all measures, U.S. consumers pay too high a price for drugs."
One of the conclusions of the Ways and Means Committee staff in a report, which compared U.S. prices for 79 Part D drugs with the prices charged in 11 other markets