TOTAL: $213.95M
Year to Date: $863.65M

Company Partner Amt. Triggering Details (Date)
(Symbol)#* (Country) (M) Event

Ardea Biosciences Inc. (IBPI) Valeant Pharmaceuticals International Inc.(NYSE:VRX) $0.5 Milestone payment Ardea received its first payment of $500,000 from Valeant for the selection of several pre-IND candidates from a family of potassium-channel openers that Ardea had been optimizing (8/16)
EPIX Pharmaceuticals Inc. (EPIX) GlaxoSmithKline plc $3 Milestone payment EPIX achieved a milestone under which it has identified three lead candidates that will move forward into lead optimization in the G-protein coupled receptor discovery program (8/14)
EPIX Pharmaceuticals Inc. (EPIX) Cystic Fibrosis Foundation Therapeutics Inc. $0.5 Milestone payment EPIX received a $500,000 payment for successfully identifying a hit compound that corrects the functionality of the cystic fibrosis transmembrane conductance regulator ion channel in a cell-based model system (8/28)
Indevus Pharmaceuticals Inc. (IDEV) Esprit Pharma Inc. $49.9 Milestone payment Indevus received the payment following the FDA approval of Sanctura XR (trospium chloride extended-release capsules) for treating overactive bladder (8/13)
Regeneron Pharmaceuticals Inc. (REGN) Bayer HealthCare AG (Germany) $20 Milestone payment For the recent initiation of a Phase III trial of VEGF Trap-Eye in the neovascular form of wet age-related macular degeneration (8/14)
Tripos Discovery Research Ltd. (OTC BB:TRPS) Gemin X Biotechnologies Inc.* ND Milestone payment In relation to the companies' January 2006 agreement; it results from the identification of a lead preclinical candidate for a Gemin X program in the study of ligands to prevent a telomeric DNA/protein interaction implicated in cancer (8/7)
Viropro International Inc. (Canada; OTC BB:VPRO) Intas Biopharmaceuticals Ltd (India) $0.05 Milestone payment Viropro received $50,000 as a down payment toward the first milestone payment in their agreement for the production of an undisclosed protein therapeutic (8/22)
Vivus Inc. (VVUS) KV Pharmaceutical $140 Milestone payment Vivus received a $140M milestone payment as part of a deal for the licensing rights for the menopause drug Evamist (estradiol) (8/9)

Notes:
# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

* Private company. Currency conversions are based on exchange rates at the time of the deal.

ND = Not disclosed. OTC BB = Over-the-Counter Bulletin Board.