I. FINANCING OF PRIVATE BIOTECHNOLOGY COMPANIES: $182.14M

Company

Location

Date

Amt. (M)

Details


Actimis
Pharmaceuticals
Inc.

San Diego

4/28/05

$6

Sanderling Ventures led the Series A financing, which also included Mitsui & Co. Venture Partners; Actimis was spun out of Bayer HealthCare AG

Affectis
Pharmaceuticals
AG

Munich, Germany

4/13/05

€4 (US$5.17)

The Series B financing round was led by EMBL Ventures; additional new investors Adamant, KfW and Sunrise Water Ltd. joined existing investors LSP, BayernKapital and the Max Planck Society

Ambrx Inc.

San Diego

4/8/05

$23.4

The second-round financing included new investors Maverick Capital, CMEA Ventures, Twilight Venture Partners and Alexandria Real Estate Equities and existing investors Tavistock Life Sciences, 5AM Ventures, Versant Ventures and Aravis Ventures

Anthera
Pharmaceuticals
Inc.

San Francisco

4/21/05

ND

The new company completed a Series A financing

CellCentric
Ltd.

Cambridge, UK

4/7/05

£0.25 (US$0.47)

The Rainbow Seed Fund invested in the financing that adds on to the company's initial round

DNage BV

Rotterdam, the Netherlands

4/13/05

€1.5 (US$2)

Inventages Venture Capital and Life Sciences Partners invested in the seed round of the firm, which was spun out of Erasmus Medical Center

GeneOhm Sciences Inc.

San Diego

4/1/05

ND

Partners HealthCare System Inc. invested in the company in a follow-on Series C financing

Gentris Corp.

Morrisville, N.C.

4/27/05

$5

Mitsui & Co. (U.S.A.) Inc. provided funding for the Series C financing round

Hamilton
Pharmaceuticals
Inc.

Washington

4/22/05

$11.1

Founding investors Vivo Ventures LLC and CNF Investments LLC were joined by Index Ventures in the Series A financing

Ikaria Inc.

Seattle

4/26/05

ND

The new company received investments from ARCH Venture Partners, Venrock Associates, 5AM Ventures, Aravis Ventures and the Washington Research Foundation

Ipsat
Therapies

Helsinki, Finland

4/4/05

€7 (US$9)

The financing round was led by Bio Fund Management Oy, with Finnish Industry Investment Ltd., the Varma Mutual Pension Insurance Co. and Sitra also investing

Merrimack
Pharmaceuticals
Inc.

Cambridge, Mass.

4/20/05

$37.3

The financing comprises $28.3M of Series D stock and a $9M venture loan; existing invest- ors Sorenson Development Inc., Unilever Technology Ventures Fund BV and Wharton Biotech- nology Partners were joined by WT Investment Advisors; the loan was provided by Hercules Technology Growth Capital

Molecular Insight Pharmaceuticals Inc.

Cambridge, Mass.

4/21/05

$28

New investors Siemens Venture Capital GmbH Corp., Tudor Investment Corp., MedCap Management & Research LLC and Emigrant Capital Corp. joined existing investors in the Series C financing round; SG Cowen & Co. was placement agent

NanoString
Technologies
Inc.

Seattle

4/27/05

$3.8

Series A investors that invested $4.3M in August 2004 increased the round to $8.1M by exercising warrants in full; the investors were Draper Fisher Jurvetson and OVP Venture Partners

Oxford Genome
Sciences Ltd.

Oxford, UK

4/4/05

ND

The South East Growth Fund led the second- round financing, and Oxford Capital Partners joined as a new investor

Receptor
Biologix Inc.

South San Francisco

4/28/05

$33.6

Skyline Ventures led the Series A financing, which also included Domain Associates, Essex Woodlands Health Ventures, MedImmune Ventures, Takeda Research Investment Inc. and Northwest Technology Ventures

Syntarga BV

Nijmegen, the Netherlands

4/15/05

ND

Aglaia Oncology Fund led the Series A financing, with BioPartner Start-up Ventures as co- investor

Talecris
Biotherapeutics
Inc.

Research Triangle Park, N.C.

4/1/05

ND

The company was formed from the purchase of Bayer HealthCare LLC's plasma business; Cerberus Capital Management LP and Ampersand Ventures provided financing for Talecris

Ventaira
Pharmaceuticals

Columbus, Ohio

4/4/05

$13.5

TL Ventures led the Series C round, which included Battelle Ventures, Battelle, Safeguard Scientific, PA Early Stage Partners, Fletcher Spaght Ventures LP, Reservoir Venture Partners and James Richardson & Sons Ltd.

Xceleron Ltd.

Heslington, UK

4/28/05

£2 (US$3.8)

Close Venture Management led the financing round with a £1.5M investment, while Foursome Investments provided £0.5M

II. MILESTONE PAYMENTS AND EQUITY INVESTMENTS FROM EXISTING CORPORATE PARTNERS: $13.0M

EntreMed
Inc.
(ENMD)

Celgene Corp.

$10.5

Warrants exercise

Celgene exercised 7M warrants at $1.50 each that it received in a December 2002 deal in which EntreMed licensed its thalidomide analogue program to Celgene (4/1)

Ligand
Pharmaceuticals
Inc.
(LGND)

TAP Pharmaceuticals Products Inc.

$1.5

Milestone payment

Triggered by TAP's submission of an IND to evaluate LGD2941, a product from their collaboration, for treating osteoporosis and frailty (4/4)

Maxim
Pharmaceuticals
Inc.
(MAXM)

Myriad Genetics Inc.

$1

Milestone payment

Triggered by dosing of the first patient in Myriad's Phase I program to evaluate safety and pharmacokinetics of MPC-6827 in patients with advanced solid tumors (4/27)

Pharmacopeia
Inc.
(PCOP)

Schering-Plough Corp.

ND

Milestone payment

Triggered by Schering-Plough's initiation of preclinical development of a small-molecule drug candidate identified in their collaboration targeted at inflammatory disease (4/13)


Notes:

# Unless otherwise indicated, shares are traded on the Nasdaq exchange.

* Private company.

Currency conversions are based on exchange rates at the time of the deal.

ND = Not disclosed.