Alfacell Corp., of Bloomfield, N.J., said it received U.S. Patent No. 6,175,003 titled "Nucleic Acids Encoding Ribonucleases and Methods of Making Them." It covers gene sequences of Onconase.

Applied Gene Technologies Inc., of San Diego, said it received U.S. Patent No. 6,187,566 titled "Method of Labeling a Nucleic Acid Amplicon With Simultaneous Contamination Prevention." It covers Tessera Array Technology, a nonamplification process involving the labeling of unpurified nucleic acid samples with luminescent compounds followed by hybridization with probes for the detection of sequence of the target market genes for infectious diseases or cancer.

Avigen Inc., of Alameda, Calif., said it received U.S. Patent No. 6,200,560. It covers treatment of hemophilia A using AAV vectors.

Bionutrics Inc., of Phoenix, Ariz., said it received U.S. Patent No. 6,187,811 titled "Methods for Treating Benign Prostatic Hyperplasia Using Tocotrienols." It covers methods for treating BPH using tocotrienols individually as well as in mixtures.

BioTransplant Inc., of Charlestown, Mass., said it received U.S. Patent No. 6,190,861 titled "Molecular Sequence of Swine Retrovirus and Methods of Use," through a license from Massachusetts General Hospital. It covers a method for screening cells or tissue for the presence of retroviruses in porcine genome.

Coley Pharmaceutical Group, of Wellesley, Mass., said it received U.S. Patent No. 6,194,388. It covers CpG immune stimulants.

Collateral Therapeutics Inc., of San Diego, said it received U.S. Patent No. 6,183,961 titled "Methods and Compositions For Regulating Cell Cycle Progression." It covers a gene involved in regulating the human cell cycle.

Copernicus Therapeutics Inc., of Cleveland, said it received U.S. Patent No. 6,200,801 through a license from Case Western Reserve University. It covers serpin enzyme complex receptor-mediated gene transfer.

Cytos Biotechnology AG, of Zurich, Switzerland, said it received U.S. Patent No. 6,197,502 titled "Expression Cloning Process for the Discovery, Characterization, and Isolation of Genes Encoding Polypeptides with a Predetermined Property." It broadly covers Cytos' technology for protein discovery and characterization.

Enzon Inc., of Piscataway, N.J., said it received U.S. Patent No. 6,172,046. It covers a method of treating hepatitis C virus-infected patients by administration of peginterferon alfa-2b and ribavirin.

Gemini Genomics plc, of Cambridge, UK, said it received U.S. Patent No. 6,156,510. It covers a method of diagnosing a predisposition to hypertension or sustained high blood pressure.

Gene Therapy Systems Inc., of San Diego, said it received U.S. Patent No. 6,165,720. It covers PNA-dependant gene chemistry technology.

Geron Corp., of Menlo Park, Calif., said it received U.S. Patent No. 6,200,806. It covers claims directed to human embryonic stem cells.

Integrative DNA Technologies Inc., of Coralville, Iowa, said it received U.S. Patent No. 6,197,944. It covers antisense technology.

Invitrogen Corp., of San Diego, said it received U.S. Patent Nos. 6,143,154 and 6,162,338. They cover Novex NuPAGE protein electrophoresis gels.

Magainin Pharmaceuticals Inc., of Plymouth Meeting, Pa., said it received a U.S. patent covering the use and administration of a blocking antibody for bronchial hyperresponsiveness and asthma treatment.

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